DNA damage checkpoint kinases in cancer
Smith, Hannah L., Southgate, Harriet, Tweddle, Deborah A., Curtin, Nicola J.
Published in Expert reviews in molecular medicine (01.01.2020)
Published in Expert reviews in molecular medicine (01.01.2020)
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Opportunities for the repurposing of PARP inhibitors for the therapy of non‐oncological diseases
Berger, Nathan A, Besson, Valerie C, Boulares, A Hamid, Bürkle, Alexander, Chiarugi, Alberto, Clark, Robert S, Curtin, Nicola J, Cuzzocrea, Salvatore, Dawson, Ted M, Dawson, Valina L, Haskó, György, Liaudet, Lucas, Moroni, Flavio, Pacher, Pál, Radermacher, Peter, Salzman, Andrew L, Snyder, Solomon H, Soriano, Francisco Garcia, Strosznajder, Robert P, Sümegi, Balázs, Swanson, Raymond A, Szabo, Csaba
Published in British journal of pharmacology (01.01.2018)
Published in British journal of pharmacology (01.01.2018)
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Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer
Batey, Michael A, Zhao, Yan, Kyle, Suzanne, Richardson, Caroline, Slade, Andrew, Martin, Niall M B, Lau, Alan, Newell, David R, Curtin, Nicola J
Published in Molecular cancer therapeutics (01.06.2013)
Published in Molecular cancer therapeutics (01.06.2013)
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Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition
Johnson, Neil, Li, Yu-Chen, Walton, Zandra E, Cheng, Katherine A, Li, Danan, Rodig, Scott J, Moreau, Lisa A, Unitt, Christine, Bronson, Roderick T, Thomas, Huw D, Newell, David R, D'Andrea, Alan D, Curtin, Nicola J, Wong, Kwok-Kin, Shapiro, Geoffrey I
Published in Nature medicine (01.07.2011)
Published in Nature medicine (01.07.2011)
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Targeting the DNA Damage Response for the Treatment of High Risk Neuroblastoma
Southgate, Harriet E D, Chen, Lindi, Curtin, Nicola J, Tweddle, Deborah A
Published in Frontiers in oncology (03.04.2020)
Published in Frontiers in oncology (03.04.2020)
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Clinicopathological Features of Homologous Recombination-Deficient Epithelial Ovarian Cancers: Sensitivity to PARP Inhibitors, Platinum, and Survival
MUKHOPADHYAY, Asima, PLUMMER, Elizabeth R, EDMONDSON, Richard J, ELATTAR, Ahmed, SOOHOO, San, UZIR, Bisha, QUINN, Jennifer E, GLENN MCCLUGGAGE, W, MAXWELL, Perry, ANEKE, Harriet, CURTIN, Nicola J
Published in Cancer research (Chicago, Ill.) (15.11.2012)
Published in Cancer research (Chicago, Ill.) (15.11.2012)
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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
HICKSON, Ian, YAN ZHAO, RICHARDSON, Caroline J, GREEN, Sharon J, MARTIN, Niall M. B, ORR, Alisdair I, REAPER, Philip M, JACKSON, Stephen P, CURTIN, Nicola J, SMITH, Graeme C. M
Published in Cancer research (Chicago, Ill.) (15.12.2004)
Published in Cancer research (Chicago, Ill.) (15.12.2004)
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The Role of ATR Inhibitors in Ovarian Cancer: Investigating Predictive Biomarkers of Response
Bradbury, Alice, Zenke, Frank T., Curtin, Nicola J., Drew, Yvette
Published in Cells (Basel, Switzerland) (01.08.2022)
Published in Cells (Basel, Switzerland) (01.08.2022)
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Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
YAN ZHAO, THOMAS, Huw D, BATEY, Michael A, COWELL, Ian G, RICHARDSON, Caroline J, GRIFFIN, Roger J, CALVERT, A. Hilary, NEWELL, David R, SMITH, Graeme C. M, CURTIN, Nicola J
Published in Cancer research (Chicago, Ill.) (15.05.2006)
Published in Cancer research (Chicago, Ill.) (15.05.2006)
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Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K
Munck, Joanne M, Batey, Michael A, Zhao, Yan, Jenkins, Helen, Richardson, Caroline J, Cano, Celine, Tavecchio, Michele, Barbeau, Jody, Bardos, Julia, Cornell, Liam, Griffin, Roger J, Menear, Keith, Slade, Andrew, Thommes, Pia, Martin, Niall M B, Newell, David R, Smith, Graeme C M, Curtin, Nicola J
Published in Molecular cancer therapeutics (01.08.2012)
Published in Molecular cancer therapeutics (01.08.2012)
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Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial
Thomas, Huw D, Calabrese, Christopher R, Batey, Michael A, Canan, Stacie, Hostomsky, Zdenek, Kyle, Suzanne, Maegley, Karen A, Newell, David R, Skalitzky, Donald, Wang, Lan-Zhen, Webber, Stephen E, Curtin, Nicola J
Published in Molecular cancer therapeutics (01.03.2007)
Published in Molecular cancer therapeutics (01.03.2007)
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Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers
Zaremba, Tomasz, Thomas, Huw D, Cole, Michael, Coulthard, Sally A, Plummer, Elizabeth R, Curtin, Nicola J
Published in Biochemical journal (15.06.2011)
Published in Biochemical journal (15.06.2011)
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The use of ovarian cancer cells from patients undergoing surgery to generate primary cultures capable of undergoing functional analysis
O Donnell, Rachel L, McCormick, Aiste, Mukhopadhyay, Asima, Woodhouse, Laura C, Moat, Madeleine, Grundy, Anna, Dixon, Michelle, Kaufman, Angelika, Soohoo, San, Elattar, Ahmed, Curtin, Nicola J, Edmondson, Richard J
Published in PloS one (06.03.2014)
Published in PloS one (06.03.2014)
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Targeting the DNA double strand break repair machinery in prostate cancer
Shaheen, Fadhel S, Znojek, Pawel, Fisher, Ann, Webster, Martin, Plummer, Ruth, Gaughan, Luke, Smith, Graeme C M, Leung, Hing Y, Curtin, Nicola J, Robson, Craig N
Published in PloS one (23.05.2011)
Published in PloS one (23.05.2011)
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Journal Article
Poly(ADP-Ribose) Polymerase-1 and DNA-Dependent Protein Kinase Have Equivalent Roles in Double Strand Break Repair Following Ionizing Radiation
Mitchell, Jody, Ph.D, Smith, Graeme C.M., Ph.D, Curtin, Nicola J., Ph.D
Published in International journal of radiation oncology, biology, physics (01.12.2009)
Published in International journal of radiation oncology, biology, physics (01.12.2009)
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