Targeting the S and G2 checkpoint to treat cancer
Chen, Tao, Stephens, Peter A., Middleton, Fiona K., Curtin, Nicola J.
Published in Drug discovery today (01.03.2012)
Published in Drug discovery today (01.03.2012)
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Ovarian Cancers Harbor Defects in Nonhomologous End Joining Resulting in Resistance to Rucaparib
McCormick, Aiste, Donoghue, Peter, Dixon, Michelle, O'Sullivan, Richard, O'Donnell, Rachel L, Murray, James, Kaufmann, Angelika, Curtin, Nicola J, Edmondson, Richard J
Published in Clinical cancer research (15.04.2017)
Published in Clinical cancer research (15.04.2017)
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Warburg and Krebs and related effects in cancer
Unterlass, Judith E, Curtin, Nicola J
Published in Expert reviews in molecular medicine (27.09.2019)
Published in Expert reviews in molecular medicine (27.09.2019)
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Journal Article
Isoindolinone-based inhibitors of the MDM2–p53 protein–protein interaction
Hardcastle, Ian R., Ahmed, Shafiq U., Atkins, Helen, Calvert, A. Hilary, Curtin, Nicola J., Farnie, Gillian, Golding, Bernard T., Griffin, Roger J., Guyenne, Sabrina, Hutton, Claire, Källblad, Per, Kemp, Stuart J., Kitching, Martin S., Newell, David R., Norbedo, Stefano, Northen, Julian S., Reid, Rebecca J., Saravanan, K., Willems, Henriëtte M.G., Lunec, John
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
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Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors
Mukhopadhyay, Asima, Elattar, Ahmed, Cerbinskaite, Aiste, Wilkinson, Sarah J, Drew, Yvette, Kyle, Suzanne, Los, Gerrit, Hostomsky, Zdenek, Edmondson, Richard J, Curtin, Nicola J
Published in Clinical cancer research (15.04.2010)
Published in Clinical cancer research (15.04.2010)
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Journal Article
Imagestream detection and characterisation of circulating tumour cells – A liquid biopsy for hepatocellular carcinoma?
Ogle, Laura F, Orr, James G, Willoughby, Catherine E, Hutton, Claire, McPherson, Stuart, Plummer, Ruth, Boddy, Alan V, Curtin, Nicola J, Jamieson, David, Reeves, Helen L
Published in Journal of hepatology (01.08.2016)
Published in Journal of hepatology (01.08.2016)
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Journal Article
Visualization of a DNA-PK/PARP1 complex
Spagnolo, Laura, Barbeau, Jody, Curtin, Nicola J, Morris, Edward P, Pearl, Laurence H
Published in Nucleic acids research (01.05.2012)
Published in Nucleic acids research (01.05.2012)
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Therapeutic Potential of Poly(ADP-ribose) Polymerase Inhibitor AG014699 in Human Cancers With Mutated or Methylated BRCA1 or BRCA2
DREW, Yvette, MULLIGAN, Evan A, EDMONDSON, Richard J, CURTIN, Nicola J, VONG, Wan-Tse, THOMAS, Huw D, KAHN, Samra, KYLE, Suzanne, MUKHOPADHYAY, Asima, LOS, Gerrit, HOSTOMSKY, Zdenek, PLUMMER, Elizabeth R
Published in JNCI : Journal of the National Cancer Institute (16.02.2011)
Published in JNCI : Journal of the National Cancer Institute (16.02.2011)
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Strategies Employed for the Development of PARP Inhibitors
Canan, Stacie, Maegley, Karen, Curtin, Nicola J
Published in Methods in molecular biology (Clifton, N.J.) (2017)
Published in Methods in molecular biology (Clifton, N.J.) (2017)
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Journal Article
Evaluating the potential of kinase inhibitors to suppress DNA repair and sensitise ovarian cancer cells to PARP inhibitors
Mukhopadhyay, Asima, Drew, Yvette, Matheson, Elizabeth, Salehan, Mo, Gentles, Lucy, Pachter, Jonathan A., Curtin, Nicola J.
Published in Biochemical pharmacology (01.09.2019)
Published in Biochemical pharmacology (01.09.2019)
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Journal Article
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Helleday, Thomas, Bryant, Helen E, Schultz, Niklas, Thomas, Huw D, Parker, Kayan M, Flower, Dan, Lopez, Elena, Kyle, Suzanne, Meuth, Mark, Curtin, Nicola J
Published in Nature (14.04.2005)
Published in Nature (14.04.2005)
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Journal Article
Characterisation of Ovarian Cancer Cell Line NIH-OVCAR3 and Implications of Genomic, Transcriptomic, Proteomic and Functional DNA Damage Response Biomarkers for Therapeutic Targeting
Bradbury, Alice, O’Donnell, Rachel, Drew, Yvette, Curtin, Nicola J., Sharma Saha, Sweta
Published in Cancers (17.07.2020)
Published in Cancers (17.07.2020)
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Journal Article
DNA-PK-A candidate driver of hepatocarcinogenesis and tissue biomarker that predicts response to treatment and survival
Cornell, Liam, Munck, Joanne M, Alsinet, Clara, Villanueva, Augusto, Ogle, Laura, Willoughby, Catherine E, Televantou, Despina, Thomas, Huw D, Jackson, Jennifer, Burt, Alastair D, Newell, David, Rose, John, Manas, Derek M, Shapiro, Geoffrey I, Curtin, Nicola J, Reeves, Helen L
Published in Clinical cancer research (15.02.2015)
Published in Clinical cancer research (15.02.2015)
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Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System
Parrish, Karen E, Cen, Ling, Murray, James, Calligaris, David, Kizilbash, Sani, Mittapalli, Rajendar K, Carlson, Brett L, Schroeder, Mark A, Sludden, Julieann, Boddy, Alan V, Agar, Nathalie Y R, Curtin, Nicola J, Elmquist, William F, Sarkaria, Jann N
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Transient treatment with CDK inhibitors eliminates proliferative potential even when their abilities to evoke apoptosis and DNA damage are blocked
Scrace, Simon F., Kierstan, Peter, Borgognoni, Jenifer, Wang, Lan-Zhen, Denny, Sarah, Wayne, Joanne, Bentley, Carol, Cansfield, Andrew D., Jackson, Philip S., Lockie, Andrea M., Curtin, Nicola J., Newell, David R., Williamson, Douglas S., Moore, Jonathan D.
Published in Cell cycle (Georgetown, Tex.) (15.12.2008)
Published in Cell cycle (Georgetown, Tex.) (15.12.2008)
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