Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations
Blanchard, Nadège, Hewitt, Nicola J, Silber, Paul, Jones, Hannah, Coassolo, Philippe, Lavé, Thierry
Published in Journal of pharmacy and pharmacology (01.05.2006)
Published in Journal of pharmacy and pharmacology (01.05.2006)
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A Novel Strategy for ADME Screening of Prodrugs: Combined Use of Serum and Hepatocytes to Integrate Bioactivation and Clearance, and Predict Exposure to Both Active and Prodrug to the Systemic Circulation
Hoppe, Edmund, Hewitt, Nicola J., Buchstaller, Hans-Peter, Eggenweiler, Hans-Michael, Sirrenberg, Christian, Zimmermann, Astrid, März, Joachim, Schwartz, Harry, Saal, Christoph, Meyring, Michael, Hecht, Stefan
Published in Journal of pharmaceutical sciences (01.05.2014)
Published in Journal of pharmaceutical sciences (01.05.2014)
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New Hepatocyte In Vitro Systems for Drug Metabolism: Metabolic Capacity and Recommendations for Application in Basic Research and Drug Development, Standard Operation Procedures
Gebhardt, Rolf, Hengstler, Jan G., Müller, Dieter, Glöckner, Reinhild, Buenning, Peter, Laube, Britta, Schmelzer, Eva, Ullrich, Martina, Utesch, Dietmar, Nicola Hewitt, Ringel, Michael, Hilz, Beate Reder, Bader, Augustinus, Langsch, Angelika, Koose, Thomas, Burger, Hans-Jörg, Maas, Jochen, Oesch, Franz
Published in Drug metabolism reviews (01.01.2003)
Published in Drug metabolism reviews (01.01.2003)
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Journal Article
Effects of the genotoxic compounds, benzo[a]pyrene and cyclophosphamide on phase 1 and 2 activities in EpiDerm™ models
Götz, Christine, Hewitt, Nicola J., Jermann, Erich, Tigges, Julia, Kohne, Zippora, Hübenthal, Ulrike, Krutmann, Jean, Merk, Hans F, Fritsche, Ellen
Published in Xenobiotica (01.06.2012)
Published in Xenobiotica (01.06.2012)
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Cosmetics Europe evaluation of 6 in silico skin penetration models
Grégoire, Sébastien, Sorrell, Ian, Lange, Daniela, Najjar, Abdulkarim, Schepky, Andreas, Ellison, Corie, Troutman, John, Fabian, Eric, Duplan, Hélène, Genies, Camille, Jacques-Jamin, Carine, Klaric, Martina, Hewitt, Nicola J.
Published in Computational toxicology (01.08.2021)
Published in Computational toxicology (01.08.2021)
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A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Skin irritation
Macfarlane, Martin, Jones, Penny, Goebel, Carsten, Dufour, Eric, Rowland, Joanna, Araki, Daisuke, Costabel-Farkas, Margit, Hewitt, Nicola J., Hibatallah, Jalila, Kirst, Annette, McNamee, Pauline, Schellauf, Florian, Scheel, Julia
Published in Regulatory toxicology and pharmacology (01.07.2009)
Published in Regulatory toxicology and pharmacology (01.07.2009)
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The role of a molecular informatics platform to support next generation risk assessment
Yang, Chihae, Rathman, James F, Bienfait, Bruno, Burbank, Matthew, Detroyer, Ann, Enoch, Steven J., Firman, James W., Gutsell, Steve, Hewitt, Nicola J., Hobocienski, Bryan, Kenna, Gerry, Madden, Judith C., Magdziarz, Tomasz, Marusczyk, Jörg, Mostrag-Szlichtyng, Aleksandra, Krueger, Christopher-Tilman, Lester, Cathy, Mahoney, Catherine, Najjar, Abdulkarim, Ouedraogo, Gladys, Przybylak, Katarzyna R., Ribeiro, J. Vinicius, Cronin, Mark T.D.
Published in Computational toxicology (01.05.2023)
Published in Computational toxicology (01.05.2023)
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Studies Comparing in Vivo:in Vitro Metabolism of Three Pharmaceutical Compounds in Rat, Dog, Monkey, and Human Using Cryopreserved Hepatocytes, Microsomes, and Collagen Gel Immobilized Hepatocyte Cultures
HEWITT, Nicola J, BÜHRING, Karl-Uhlrich, DASENBROCK, Johannes, HAUNSCHILD, Jutta, LADSTETTER, Bernhard, UTESCH, Dietmar
Published in Drug metabolism and disposition (01.07.2001)
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Published in Drug metabolism and disposition (01.07.2001)
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Differential in vitro hepatotoxicity of troglitazone and rosiglitazone among cryopreserved human hepatocytes from 37 donors
Lloyd, Scott, Hayden, Michael J, Sakai, Yumiko, Fackett, Andrew, Silber, Paul M, Hewitt, Nicola J, Li, Albert P
Published in Chemico-biological interactions (10.11.2002)
Published in Chemico-biological interactions (10.11.2002)
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Journal Article
Correlation between troglitazone cytotoxicity and drug metabolic enzyme activities in cryopreserved human hepatocytes
Hewitt, Nicola J, Lloyd, Scott, Hayden, Mike, Butler, Ryan, Sakai, Yumiko, Springer, Ryan, Fackett, Andrew, Li, Albert P
Published in Chemico-biological interactions (10.11.2002)
Published in Chemico-biological interactions (10.11.2002)
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Validation of the 3D reconstructed human skin Comet assay, an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays
Pfuhler, Stefan, Pirow, Ralph, Downs, Thomas R, Haase, Andrea, Hewitt, Nicola, Luch, Andreas, Merkel, Marion, Petrick, Claudia, Said, André, Schäfer-Korting, Monika, Reisinger, Kerstin
Published in Mutagenesis (28.04.2021)
Published in Mutagenesis (28.04.2021)
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In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters
Najjar, Abdulkarim, Grégoire, Sebastien, Nicol, Beate, Natsch, Andreas, Golbamaki, Nazanin, Boisleve, Fanny, Irizar, Amaia, Wall, Brian, Swinscoe, Angus, Masini-Etévé, Valérie, Selechnik, Dan, Api, Anne Marie, Griem, Peter, Hewitt, Nicola, Cardamone, Estefania
Published in Archives of toxicology (01.07.2024)
Published in Archives of toxicology (01.07.2024)
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Journal Article
Direct and quantitative evaluation of the major human CYP contribution (fmCYP) to drug clearance using the in vitro Silensomes™ model
Parmentier, Yannick, Pothier, Corinne, Hewitt, Nicola, Vincent, Ludwig, Caradec, Fabrice, Liu, Jia, Lin, Feifei, Trancart, Marie-Michèle, Guillet, Fabrice, Bouaita, Belkacem, Chesne, Christophe, Walther, Bernard
Published in Xenobiotica (02.01.2019)
Published in Xenobiotica (02.01.2019)
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In-vitro-only testing strategies for cosmetic ingredients: Utility of newly validated genotoxicity assays using human skin and fertilized hen's eggs
Desprez, Bertrand, Fautz, Rolf, Hoffmann, Sebastian, Hewitt, Nicola, Fowler, Paul, Reisinger, Kerstin, Kuehnl, Jochen, Ouédraogo, Gladys, Kenny, Julia, Pfuhler, Stefan
Published in Toxicology letters (20.10.2017)
Published in Toxicology letters (20.10.2017)
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Pesticide Exposure of Operators from Drone Application: A Field Study with Comparative Analysis to Handheld Data from Exposure Models
Kuster, Christian J, Kohler, Maxie, Hovinga, Sarah, Timmermann, Christian, Hamacher, Georg, Buerling, Kathrin, Chen, Lirong, Hewitt, Nicola J., Anft, Thomas
Published in ACS agricultural science & technology (18.12.2023)
Published in ACS agricultural science & technology (18.12.2023)
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Journal Article
Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes
Götz, Christine, Pfeiffer, Roland, Tigges, Julia, Ruwiedel, Karsten, Hübenthal, Ulrike, Merk, Hans F, Krutmann, Jean, Edwards, Robert J., Abel, Josef, Pease, Camilla, Goebel, Carsten, Hewitt, Nicola, Fritsche, Ellen
Published in Experimental dermatology (01.05.2012)
Published in Experimental dermatology (01.05.2012)
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Journal Article
Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I)
Götz, Christine, Pfeiffer, Roland, Tigges, Julia, Blatz, Veronika, Jäckh, Christine, Freytag, Eva-Maria, Fabian, Eric, Landsiedel, Robert, Merk, Hans F, Krutmann, Jean, Edwards, Robert J, Pease, Camilla, Goebel, Carsten, Hewitt, Nicola, Fritsche, Ellen
Published in Experimental dermatology (01.05.2012)
Published in Experimental dermatology (01.05.2012)
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