Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion
Najjar, Abdulkarim, Kühnl, Jochen, Lange, Daniela, Géniès, Camille, Jacques, Carine, Fabian, Eric, Zifle, Anne, Hewitt, Nicola J., Schepky, Andreas
Published in Frontiers in pharmacology (19.06.2024)
Published in Frontiers in pharmacology (19.06.2024)
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Journal Article
Use of a Simple in vitro Test to Assess Loss of Chemical due to Volatility during an in vitro Human Skin Absorption Study
Grégoire, Sébastien, Cubberley, Richard, Duplan, Hélène, Eilstein, Joan, Hewitt, Nicola J., Jacques-Jamin, Carine, Genies, Camille, Klaric, Martina, Rothe, Helga, Ellison, Corie, Fernandez, Julien, Schepky, Andreas
Published in Skin pharmacology and physiology (01.05.2019)
Published in Skin pharmacology and physiology (01.05.2019)
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Journal Article
Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first-pass skin metabolism of the hair dye, 4-amino-2-hydroxytoluene
Brandmair, Katrin, Tao, Thi-Phuong, Gerlach, Silke, Przibilla, Julia, Schepky, Andreas, Marx, Uwe, Hewitt, Nicola J, Kühnl, Jochen, Maschmeyer, Ilka
Published in Journal of applied toxicology (01.03.2024)
Published in Journal of applied toxicology (01.03.2024)
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Journal Article
New framework for a non-animal approach adequately assures the safety of cosmetic ingredients – A case study on caffeine
Bury, Dagmar, Alexander-White, Camilla, Clewell, Harvey J., Cronin, Mark, Desprez, Bertrand, Detroyer, Ann, Efremenko, Alina, Firman, James, Hack, Eric, Hewitt, Nicola J., Kenna, Gerry, Klaric, Martina, Lester, Cathy, Mahony, Catherine, Ouedraogo, Gladys, Paini, Alicia, Schepky, Andreas
Published in Regulatory toxicology and pharmacology (01.07.2021)
Published in Regulatory toxicology and pharmacology (01.07.2021)
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Journal Article
Validation of the 3D reconstructed human skin micronucleus (RSMN) assay: an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays
Pfuhler, Stefan, Downs, Thomas R, Hewitt, Nicola J, Hoffmann, Sebastian, Mun, Greg C, Ouedraogo, Gladys, Roy, Shambhu, Curren, Rodger D, Aardema, Marilyn J
Published in Mutagenesis (28.04.2021)
Published in Mutagenesis (28.04.2021)
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A comprehensive view on mechanistic approaches for cancer risk assessment of non-genotoxic agrochemicals
Luijten, Mirjam, Corvi, Raffaella, Mehta, Jyotigna, Corvaro, Marco, Delrue, Nathalie, Felter, Susan, Haas, Bodo, Hewitt, Nicola J., Hilton, Gina, Holmes, Thomas, Jacobs, Miriam N., Jacobs, Abigail, Lamplmair, Franz, Lewis, Dick, Madia, Federica, Manou, Irene, Melching-Kollmuss, Stephanie, Schorsch, Frederic, Schütte, Katrin, Sewell, Fiona, Strupp, Christian, van der Laan, Jan Willem, Wolf, Douglas C., Wolterink, Gerrit, Woutersen, Ruud, Zvonar, Zvonimir, Heusinkveld, Harm, Braakhuis, Hedwig
Published in Regulatory toxicology and pharmacology (01.12.2020)
Published in Regulatory toxicology and pharmacology (01.12.2020)
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Journal Article
Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure
Ebmeyer, Johanna, Najjar, Abdulkarim, Lange, Daniela, Boettcher, Mareike, Voß, Silja, Brandmair, Katrin, Meinhardt, Jaqueline, Kuehnl, Jochen, Hewitt, Nicola J, Krueger, Christopher-Tilman, Schepky, Andreas
Published in Frontiers in pharmacology (07.03.2024)
Published in Frontiers in pharmacology (07.03.2024)
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Workshop report: Challenges faced in developing inhalation thresholds of Toxicological Concern (TTC) - State of the science and next steps
Bowden, Anthony M., Escher, Sylvia E., Rose, Jane, Sadekar, Nikaeta, Patlewicz, Grace, O'Keeffe, Lara, Bury, Dagmar, Hewitt, Nicola J., Giusti, Arianna, Rothe, Helga
Published in Regulatory toxicology and pharmacology (01.08.2023)
Published in Regulatory toxicology and pharmacology (01.08.2023)
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Journal Article
Use of in vitro metabolism and biokinetics assays to refine predicted in vivo and in vitro internal exposure to the cosmetic ingredient, phenoxyethanol, for use in risk assessment
Hewitt, Nicola J., Troutman, John, Przibilla, Julia, Schepky, Andreas, Ouédraogo, Gladys, Mahony, Catherine, Kenna, Gerry, Varçin, Mustafa, Dent, Mathew P.
Published in Regulatory toxicology and pharmacology (01.06.2022)
Published in Regulatory toxicology and pharmacology (01.06.2022)
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Journal Article
Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models
Lester, Cathy, Hewitt, Nicola J., Müller-Vieira, Ursula, Mayer, Manuela, Ellison, Corie, Duplan, Hélène, Genies, Camille, Jacques-Jamin, Carine, Fabian, Eric, Sorrell, Ian, Lange, Daniela, Schepky, Andreas, Grégoire, Sébastien
Published in Toxicology in vitro (01.04.2021)
Published in Toxicology in vitro (01.04.2021)
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Journal Article
Measurements of the dermal exposure to bystanders from direct off‐crop drift during the application of plant protection products
Kuster, Christian J., Hewitt, Nicola J., Butler Ellis, Clare, Timmermann, Christian, Anft, Thomas
Published in Annals of applied biology (01.07.2021)
Published in Annals of applied biology (01.07.2021)
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Journal Article
Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions
Tao, Thi-Phuong, Maschmeyer, Ilka, LeCluyse, Edward L, Rogers, Eda, Brandmair, Katrin, Gerlach, Silke, Przibilla, Julia, Kern, Fredy, Genies, Camille, Jacques, Carine, Najjar, Abdulkarim, Schepky, Andreas, Marx, Uwe, Kühnl, Jochen, Hewitt, Nicola J
Published in Frontiers in pharmacology (08.02.2023)
Published in Frontiers in pharmacology (08.02.2023)
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Journal Article
Use of Physiologically-Based Kinetics Modelling to Reliably Predict Internal Concentrations of the UV Filter, Homosalate, After Repeated Oral and Topical Application
Najjar, Abdulkarim, Schepky, Andreas, Krueger, Christopher-Tilman, Dent, Matthew, Cable, Sophie, Li, Hequn, Grégoire, Sebastien, Roussel, Laurene, Noel-Voisin, Audrey, Hewitt, Nicola J, Cardamone, Estefania
Published in Frontiers in pharmacology (04.01.2022)
Published in Frontiers in pharmacology (04.01.2022)
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Journal Article
The EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay: Historical control data and proof of principle studies for mechanistic assay adaptations
Roy, Shambhu, Kulkarni, Rohan, Hewitt, Nicola J., Aardema, Marilyn J.
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.07.2016)
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.07.2016)
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Use of in vitro metabolomics in NRK cells to help predicting nephrotoxicity and differentiating the MoA of nephrotoxicants
Birk, Barbara, Haake, Volker, Sperber, Saskia, Herold, Michael, Wallisch, Svenja K., Huener, Hans-Albrecht, Verlohner, Andreas, Amma, Meike M., Walk, Tilmann, Hernandez, Tzutzuy Ramirez, Hewitt, Nicola J., Kamp, Hennicke, van Ravenzwaay, Bennard
Published in Toxicology letters (15.12.2021)
Published in Toxicology letters (15.12.2021)
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Journal Article
Suitability of the in vitro Caco-2 assay to predict the oral absorption of aromatic amine hair dyes
Obringer, Cindy, Manwaring, John, Goebel, Carsten, Hewitt, Nicola J., Rothe, Helga
Published in Toxicology in vitro (01.04.2016)
Published in Toxicology in vitro (01.04.2016)
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Journal Article
A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme
Desprez, Bertrand, Dent, Matt, Keller, Detlef, Klaric, Martina, Ouédraogo, Gladys, Cubberley, Richard, Duplan, Hélène, Eilstein, Joan, Ellison, Corie, Grégoire, Sébastien, Hewitt, Nicola J., Jacques-Jamin, Carine, Lange, Daniela, Roe, Amy, Rothe, Helga, Blaauboer, Bas J., Schepky, Andreas, Mahony, Catherine
Published in Toxicology in vitro (01.08.2018)
Published in Toxicology in vitro (01.08.2018)
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