Brain cell type-specific enhancer-promoter interactome maps and disease - risk association
Nott, Alexi, Holtman, Inge R, Coufal, Nicole G, Schlachetzki, Johannes C M, Yu, Miao, Hu, Rong, Han, Claudia Z, Pena, Monique, Xiao, Jiayang, Wu, Yin, Keulen, Zahara, Pasillas, Martina P, O'Connor, Carolyn, Nickl, Christian K, Schafer, Simon T, Shen, Zeyang, Rissman, Robert A, Brewer, James B, Gosselin, David, Gonda, David D, Levy, Michael L, Rosenfeld, Michael G, McVicker, Graham, Gage, Fred H, Ren, Bing, Glass, Christopher K
Published in Science (American Association for the Advancement of Science) (29.11.2019)
Published in Science (American Association for the Advancement of Science) (29.11.2019)
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Journal Article
Epigenetic silencing of SOCS5 potentiates JAK‐STAT signaling and progression of T‐cell acute lymphoblastic leukemia
Sharma, Nitesh D., Nickl, Christian K., Kang, Huining, Ornatowski, Wojciech, Brown, Roger, Ness, Scott A., Loh, Mignon L., Mullighan, Charles G., Winter, Stuart S., Hunger, Stephen P., Cannon, Judy L., Matlawska‐Wasowska, Ksenia
Published in Cancer science (01.06.2019)
Published in Cancer science (01.06.2019)
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Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication
Osborne, Brent W., Wu, Jian, McFarland, Caitlin J., Nickl, Christian K., Sankaran, Banumathi, Casteel, Darren E., Woods, Virgil L., Kornev, Alexandr P., Taylor, Susan S., Dostmann, Wolfgang R.
Published in Structure (London) (07.09.2011)
Published in Structure (London) (07.09.2011)
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Journal Article
Dysregulated transcriptional networks in KMT2A- and MLLT10 -rearranged T-ALL
Kang, Huining, Sharma, Nitesh D, Nickl, Christian K, Devidas, Meenakshi, Loh, Mignon L, Hunger, Stephen P, Dunsmore, Kimberly P, Winter, Stuart S, Matlawska-Wasowska, Ksenia
Published in Biomarker research (23.08.2018)
Published in Biomarker research (23.08.2018)
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Journal Article
Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes
Bennett, Hunter, Troutman, Ty D., Zhou, Enchen, Spann, Nathanael J., Link, Verena M., Seidman, Jason S., Nickl, Christian K., Abe, Yohei, Sakai, Mashito, Pasillas, Martina P., Marlman, Justin M., Guzman, Carlos, Hosseini, Mojgan, Schnabl, Bernd, Glass, Christopher K.
Published in Nature immunology (01.11.2023)
Published in Nature immunology (01.11.2023)
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Journal Article
Inhibition of cGMP-Dependent Protein Kinase by the Cell-Permeable Peptide DT-2 Reveals a Novel Mechanism of Vasoregulation
Taylor, Mark S, Okwuchukwuasanya, Chris, Nickl, Christian K, Tegge, Werner, Brayden, Joseph E, Dostmann, Wolfgang R G
Published in Molecular pharmacology (01.05.2004)
Published in Molecular pharmacology (01.05.2004)
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Journal Article
RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia
Matthijssens, Filip, Sharma, Nitesh D, Nysus, Monique, Nickl, Christian K, Kang, Huining, Perez, Dominique R, Lintermans, Beatrice, Van Loocke, Wouter, Roels, Juliette, Peirs, Sofie, Demoen, Lisa, Pieters, Tim, Reunes, Lindy, Lammens, Tim, De Moerloose, Barbara, Van Nieuwerburgh, Filip, Deforce, Dieter L, Cheung, Laurence C, Kotecha, Rishi S, Risseeuw, Martijn Dp, Van Calenbergh, Serge, Takarada, Takeshi, Yoneda, Yukio, van Delft, Frederik W, Lock, Richard B, Merkley, Seth D, Chigaev, Alexandre, Sklar, Larry A, Mullighan, Charles G, Loh, Mignon L, Winter, Stuart S, Hunger, Stephen P, Goossens, Steven, Castillo, Eliseo F, Ornatowski, Wojciech, Van Vlierberghe, Pieter, Matlawska-Wasowska, Ksenia
Published in The Journal of clinical investigation (15.03.2021)
Published in The Journal of clinical investigation (15.03.2021)
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Journal Article
Epigenetic silencing of SOCS 5 potentiates JAK ‐ STAT signaling and progression of T‐cell acute lymphoblastic leukemia
Sharma, Nitesh D., Nickl, Christian K., Kang, Huining, Ornatowski, Wojciech, Brown, Roger, Ness, Scott A., Loh, Mignon L., Mullighan, Charles G., Winter, Stuart S., Hunger, Stephen P., Cannon, Judy L., Matlawska‐Wasowska, Ksenia
Published in Cancer science (01.06.2019)
Published in Cancer science (01.06.2019)
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Journal Article
Direct modulation of the protein kinase a catalytic subunit α by growth factor receptor tyrosine kinases
Caldwell, George B., Howe, Alan K., Nickl, Christian K., Dostmann, Wolfgang R., Ballif, Bryan A., Deming, Paula B.
Published in Journal of cellular biochemistry (01.01.2012)
Published in Journal of cellular biochemistry (01.01.2012)
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Journal Article
High-Throughput Flow Cytometry Identifies Small-Molecule Inhibitors for Drug Repurposing in T-ALL
Perez, Dominique R., Nickl, Christian K., Waller, Anna, Delgado-Martin, Cristina, Woods, Travis, Sharma, Nitesh D., Hermiston, Michelle L., Loh, Mignon L., Hunger, Stephen P., Winter, Stuart S., Chigaev, Alexandre, Edwards, Bruce, Sklar, Larry A., Matlawska-Wasowska, Ksenia
Published in SLAS discovery (01.08.2018)
Published in SLAS discovery (01.08.2018)
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Journal Article
Adenosine analogue–oligo-arginine conjugates (ARCs) serve as high-affinity inhibitors and fluorescence probes of type I cGMP-dependent protein kinase (PKGIα)
Lavogina, Darja, Nickl, Christian K., Enkvist, Erki, Raidaru, Gerda, Lust, Marje, Vaasa, Angela, Uri, Asko, Dostmann, Wolfgang R.
Published in Biochimica et biophysica acta (01.09.2010)
Published in Biochimica et biophysica acta (01.09.2010)
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Journal Article
Highly Specific, Membrane-Permeant Peptide Blockers of cGMP-Dependent Protein Kinase Iα Inhibit NO-Induced Cerebral Dilation
Dostmann, Wolfgang R. G., Taylor, Mark S., Nickl, Christian K., Brayden, Joseph E., Frank, Ronald, Tegge, Werner J.
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2000)
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Journal Article
Pyrosequencing for Classification of Human FcγRIIIA Allotypes: A Comparison with PCR-Based Techniques
Matlawska-Wasowska, Ksenia, Gale, James M., Nickl, Christian K., Khalili, Parisa, Shirley, Brian, Wilson, Bridget S., Vasef, Mohammad A., Winter, Stuart S.
Published in Molecular diagnosis & therapy (01.12.2014)
Published in Molecular diagnosis & therapy (01.12.2014)
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Journal Article
Systematic analysis of transcriptional and epigenetic effects of genetic variation in Kupffer cells enables discrimination of cell intrinsic and environment-dependent mechanisms
Hunter, Bennett, Troutman, Ty D, Zhou, Enchen, Spann, Nathaneal J, Link, Verena M, Seidman, Jason S, Nickl, Christian K, Abe, Yohei, Sakai, Mashito, Pasillas, Martina P, Marlman, Justin M, Guzman, Carlos, Hosseini, Mojgan, Schnabl, Bernd, Glass, Christopher K
Published in bioRxiv (23.09.2022)
Published in bioRxiv (23.09.2022)
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Paper
Abstract 4129: RUNX2 as a regulator of high-risk T-ALL
Sharma, Nitesh Devinarayan, Nickl, Christian K., Winter, Stuart S., Kang, Huining, Wasowska, Ksenia Matlawska
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Genome-Based Treatment Algorithm to Prevent Relapse in Children and Young Adults with Acute Lymphoblastic Leukemia: A Prospective Feasibility Study
Mayfield, Jodi, Czuchlewski, David, Gale, James, Matlawska-Wasowska, Ksenia, Vasef, Mohammad, Nickl, Christian K, Arana Yi, Cecilia, Pickett, Gavin, Ness, Scott, Winter, Stuart S.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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MLL rearrangements impact outcome in HOXA-deregulated T-lineage acute lymphoblastic leukemia: a Children’s Oncology Group Study
Matlawska-Wasowska, K, Kang, H, Devidas, M, Wen, J, Harvey, R C, Nickl, C K, Ness, S A, Rusch, M, Li, Y, Onozawa, M, Martinez, C, Wood, B L, Asselin, B L, Chen, I-M, Roberts, K G, Baruchel, A, Soulier, J, Dombret, H, Zhang, J, Larson, R S, Raetz, E A, Carroll, W L, Winick, N J, Aplan, P D, Loh, M L, Mullighan, C G, Hunger, S P, Heerema, N A, Carroll, A J, Dunsmore, K P, Winter, S S
Published in Leukemia (01.09.2016)
Published in Leukemia (01.09.2016)
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Journal Article
Variability In Precursor B ALL Killing With Moxetumomab Pasudotox (CAT-8015) Linked To Differential Binding and Endocytic Trafficking
Matlawska-Wasowska, Ksenia, Nickl, Christian K., Winter, Stuart S., Burke, Patricia, LaVallee, Theresa, Wilson, Bridget S.
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Journal Article
New Insights into Deregulated Gene Expression Pathways in MLL- and AF10-Rearranged T-Lineage Acute Lymphoblastic Leukemia
Kang, Huining, Sharma, Nitesh, Nickl, Christian K, Ness, Scott, Devidas, Meenakshi, Wood, Brent L., Asselin, Barbara L., Raetz, Elizabeth, Carroll, William L., Winick, Naomi, Loh, Mignon L., Hunger, Stephen P., Heerema, Nyla A., Carroll, Andrew J., Dunsmore, Kimberly P., Larson, Richard S., Winter, Stuart S., Matlawska-Wasowska, Ksenia
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
(d)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Iα
Nickl, Christian K., Raidas, Shiv Kumar, Zhao, Hong, Sausbier, Matthias, Ruth, Peter, Tegge, Werner, Brayden, Joseph E., Dostmann, Wolfgang R.
Published in Biochimica et biophysica acta (01.03.2010)
Published in Biochimica et biophysica acta (01.03.2010)
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Journal Article