Design, Parallel Synthesis, and Crystal Structures of Pyrazinone Antithrombotics as Selective Inhibitors of the Tissue Factor VIIa Complex
Parlow, John J, Case, Brenda L, Dice, Thomas A, Fenton, Ricky L, Hayes, Michael J, Jones, Darin E, Neumann, William L, Wood, Rhonda S, Lachance, Rhonda M, Girard, Thomas J, Nicholson, Nancy S, Clare, Michael, Stegeman, Roderick A, Stevens, Anna M, Stallings, William C, Kurumbail, Ravi G, South, Michael S
Published in Journal of medicinal chemistry (11.09.2003)
Published in Journal of medicinal chemistry (11.09.2003)
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Pharmacological Interruption of Acute Thrombus Formation with Minimal Hemorrhagic Complications by a Small Molecule Tissue Factor/Factor VIIa Inhibitor: Comparison to Factor Xa and Thrombin Inhibition in a Nonhuman Primate Thrombosis Model
Suleymanov, Osman D, Szalony, James A, Salyers, Anita K, LaChance, Rhonda M, Parlow, John J, South, Michael S, Wood, Rhonda S, Nicholson, Nancy S
Published in The Journal of pharmacology and experimental therapeutics (01.09.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2003)
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Potent in vitro and in vivo inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Arg-guanidine of RGDX mimetics and the platelet GP IIb-IIIa receptor
Zablocki, Jeffery A, Miyano, Masateru, Garland, Robert B, Pireh, Daisy, Schretzman, Lori, Rao, Shashidhar N, Lindmark, Richard J, Panzer-Knodle, Susan G, Nicholson, Nancy S
Published in Journal of medicinal chemistry (01.06.1993)
Published in Journal of medicinal chemistry (01.06.1993)
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The role of tissue factor/factor VIIa in the pathophysiology of acute thrombotic formation
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Book Review
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Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex
South, Michael S., Case, Brenda L., Wood, Rhonda S., Jones, Darin E., Hayes, Michael J., Girard, Thomas J., Lachance, Rhonda M., Nicholson, Nancy S., Clare, Michael, Stevens, Anna M., Stegeman, Roderick A., Stallings, William C., Kurumbail, Ravi G., Parlow, John J.
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
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Journal Article
Administration of a small molecule tissue factor/Factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: effects on thrombus formation and bleeding time
Szalony, James A, Suleymanov, Osman D, Salyers, Anita K, Panzer-Knodle, Susan G, Blom, Jason D, LaChance, Rhonda M, Case, Brenda L, Parlow, John J, South, Michael S, Wood, Rhonda S, Nicholson, Nancy S
Published in Thrombosis research (2003)
Published in Thrombosis research (2003)
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Pharmacological intervention at disparate sites in the coagulation cascade: Comparison of anti-thrombotic efficacy vs. bleeding propensity in a rat model of acute arterial thrombosis
SZALONY, James A, TAITE, Beatrice B, GIRARD, Thomas J, NICHOLSON, Nancy S, LACHANCE, Rhonda M
Published in Journal of thrombosis and thrombolysis (01.10.2002)
Published in Journal of thrombosis and thrombolysis (01.10.2002)
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Journal Article
Assessment of Bleeding Propensity in Non-Human Primates by Combination of Selective Tissue Factor/VIIa Inhibition and Aspirin Compared to Warfarin and Aspirin Treatment
Salyers, Anita K., Szalony, James A., Suleymanov, Osman D., Parlow, John J., Wood, Rhonda S., South, Michael S., Nicholson, Nancy S.
Published in Pharmacology (01.02.2004)
Published in Pharmacology (01.02.2004)
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Orbofiban: An orally active GPIIb/IIIa platelet receptor antagonist
Nicholson, Nancy S., Abood, Norman A., Panzer-Knodle, Susan G., Frederick, Leo G., Page, Jimmy D., Salyers, Anita K., Suleymanov, Osman D., Szalony, James A., Taite, Beatrice B., Anders, Robert J.
Published in Medicinal research reviews (01.05.2001)
Published in Medicinal research reviews (01.05.2001)
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A method for determining whether hypotension caused by novel compounds in preclinical development results from histamine release
Blom, Jason D., Yang, Po-Chang, Nicholson, Nancy S., Case, Brenda L., Parlow, John J., South, Michael S., Wegner, Craig D.
Published in Journal of pharmacological and toxicological methods (2004)
Published in Journal of pharmacological and toxicological methods (2004)
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Journal Article
SC-54684A : an orally active inhibitor of platelet aggregation
NICHOLSON, N. S, PANZER-KNODLE, S. G, ENGLEMAN, V. W, HERIN, M, JACQMIN, P, FEIGEN, L. P, SALYERS, A. K, TAITE, B. B, SZALONY, J. A, HAAS, N. F, KING, L. W, ZABLOCKI, J. A, KELLER, B. T, BROSCHAT, K
Published in Circulation (New York, N.Y.) (15.01.1995)
Published in Circulation (New York, N.Y.) (15.01.1995)
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Journal Article
Extended inhibition of platelet aggregation with the orally active platelet inhibitor SC-54684A
SZALONY, J. A, HAAS, N. F, SALYERS, A. K, TAITE, B. B, NICHOLSON, N. S, MEHROTRA, D. V, FEIGEN, L. P
Published in Circulation (New York, N.Y.) (15.01.1995)
Published in Circulation (New York, N.Y.) (15.01.1995)
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Journal Article
The protective dose of the potent GPIIb/IIIa antagonist SC-54701A is reduced when used in combination with aspirin and heparin in a canine model of coronary artery thrombosis
FREDERICK, L. G, SULEYMANOV, O. D, KING, L. W, SALYERS, A. K, NICHOLSON, N. S, FEIGEN, L. P
Published in Circulation (New York, N.Y.) (1996)
Published in Circulation (New York, N.Y.) (1996)
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Journal Article
Protective effect of oral xemilofiban in arterial thrombosis in dogs: Increased activity in combination with aspirin
FREDERICK, L. G, SULEYMANOV, O. D, SZALONY, J. A, TAITE, B. B, SALYERS, A. K, KING, L. W, FEIGEN, L. P, NICHOLSON, N. S
Published in Circulation (New York, N.Y.) (25.08.1998)
Published in Circulation (New York, N.Y.) (25.08.1998)
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Assessment of platelet function assays
Nicholson, Nancy S., Panzer-Knodle, Susan G., Haas, Neal F., Taite, Beatrice B., Szalony, James A., Page, Jimmy D., Feigen, Larry P., Lansky, David M., Salyers, Anita K.
Published in The American heart journal (01.05.1998)
Published in The American heart journal (01.05.1998)
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Potent in Vitro and in Vivo Inhibitors of Platelet Aggregation Based Upon the Arg-Gly-Asp Sequence of Fibrinogen. (Aminobenzamidino)succinyl (ABAS) Series of Orally Active Fibrinogen Receptor Antagonists
Zablocki, Jeffery A, Rico, Joseph G, Garland, Robert B, Rogers, Thomas E, Williams, Kenneth, Schretzman, Lori A, Rao, Shashidhar A, Bovy, Philippe R, Tjoeng, Foe S
Published in Journal of medicinal chemistry (01.06.1995)
Published in Journal of medicinal chemistry (01.06.1995)
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Journal Article
A novel series of orally active antiplatelet agents
Zablocki, Jeffery A., Tjoeng, Foe S., Bovy, Philippe R., Miyano, Masateru, Garland, Robert B., Williams, Kenneth, Schretzman, Lori, Zupec, Mark E., Rico, Joseph G., Lindmark, Richard J., Toth, Mihaly V., McMackins, Dudley E., Adams, Steven P., Panzer-Knodle, Susan G., Nicholson, Nancy S., Taite, Beatrice B., Salyers, Anita K., King, Lucy W., Campion, James G., Feigen, Larry P.
Published in Bioorganic & medicinal chemistry (01.05.1995)
Published in Bioorganic & medicinal chemistry (01.05.1995)
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Journal Article
SC-49992-A potent and specific inhibitor of platelet aggregation
Nicholson, Nancy S., Panzer-Knodle, Susan G., King, Lucy W., Taite, Beatrice B., Keller, Brad T., Tjoeng, F.Siong, Engleman, V.Wayne, Giorgio, Todd D., Feigen, Larry P.
Published in Thrombosis research (01.06.1994)
Published in Thrombosis research (01.06.1994)
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