Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages
Wan, W Brad, Migawa, Michael T, Vasquez, Guillermo, Murray, Heather M, Nichols, Josh G, Gaus, Hans, Berdeja, Andres, Lee, Sam, Hart, Christopher E, Lima, Walt F, Swayze, Eric E, Seth, Punit P
Published in Nucleic acids research (16.12.2014)
Published in Nucleic acids research (16.12.2014)
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Journal Article
Binding and Cleavage Specificities of Human Argonaute2
Lima, Walt F., Wu, Hongjiang, Nichols, Josh G., Sun, Hong, Murray, Heather M., Crooke, Stanley T.
Published in The Journal of biological chemistry (18.09.2009)
Published in The Journal of biological chemistry (18.09.2009)
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Journal Article
Human RNase H1 Discriminates between Subtle Variations in the Structure of the Heteroduplex Substrate
Lima, Walt F, Rose, John B, Nichols, Josh G, Wu, Hongjiang, Migawa, Michael T, Wyrzykiewicz, Tadeusz K, Siwkowski, Andrew M, Crooke, Stanley T
Published in Molecular pharmacology (01.01.2007)
Published in Molecular pharmacology (01.01.2007)
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Journal Article
Human Dicer Binds Short Single-strand and Double-strand RNA with High Affinity and Interacts with Different Regions of the Nucleic Acids
Lima, Walt F., Murray, Heather, Nichols, Josh G., Wu, Hongjiang, Sun, Hong, Prakash, Thazha P., Berdeja, Andres R., Gaus, Hans J., Crooke, Stanley T.
Published in The Journal of biological chemistry (23.01.2009)
Published in The Journal of biological chemistry (23.01.2009)
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Journal Article
Structural Requirements at the Catalytic Site of the Heteroduplex Substrate for Human RNase H1 Catalysis
Lima, Walt F, Nichols, Josh G, Wu, Hongjiang, Prakash, Thazha P, Migawa, Mike T, Wyrzykiewicz, Tadensz K, Bhat, Balkrishen, Crooke, Stanley T
Published in The Journal of biological chemistry (27.08.2004)
Published in The Journal of biological chemistry (27.08.2004)
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Journal Article
The Positional Influence of the Helical Geometry of the Heteroduplex Substrate on Human RNase H1 Catalysis
Lima, Walt F, Rose, John B, Nichols, Josh G, Wu, Hongjiang, Migawa, Michael T, Wyrzykiewicz, Tadeusz K, Vasquez, Guillermo, Swayze, Eric E, Crooke, Stanley T
Published in Molecular pharmacology (01.01.2007)
Published in Molecular pharmacology (01.01.2007)
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Journal Article
Human RNase H1 Uses One Tryptophan and Two Lysines to Position the Enzyme at the 3′-DNA/5′-RNA Terminus of the Heteroduplex Substrate
Lima, Walt F., Wu, Hongjiang, Nichols, Josh G., Prakash, Thazha P., Ravikumar, Vasulinga, Crooke, Stanley T.
Published in The Journal of biological chemistry (12.12.2003)
Published in The Journal of biological chemistry (12.12.2003)
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Journal Article
Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells
Vickers, Timothy A, Lima, Walt F, Nichols, Josh G, Crooke, Stanley T
Published in Nucleic acids research (01.10.2007)
Published in Nucleic acids research (01.10.2007)
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Journal Article
Human RNase H1 Activity Is Regulated by a Unique Redox Switch Formed between Adjacent Cysteines
Lima, Walt F., Wu, Hongjiang, Nichols, Josh G., Manalili, Sherilynn M., Drader, Jared J., Hofstadler, Steven A., Crooke, Stanley T.
Published in The Journal of biological chemistry (25.04.2003)
Published in The Journal of biological chemistry (25.04.2003)
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Journal Article
Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1
Vickers, Timothy A, Lima, Walt F, Wu, Hongjiang, Nichols, Josh G, Linsley, Peter S, Crooke, Stanley T
Published in Nucleic acids research (01.11.2009)
Published in Nucleic acids research (01.11.2009)
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Journal Article
Human RNase H1 Uses One Tryptophan and Two Lysines to Position the Enzyme at the 3â²-DNA/5â²-RNA Terminus of the Heteroduplex Substrate
Walt F. Lima, Hongjiang Wu, Josh G. Nichols, Thazha P. Prakash, Vasulinga Ravikumar, Stanley T. Crooke
Published in The Journal of biological chemistry (12.12.2003)
Published in The Journal of biological chemistry (12.12.2003)
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Journal Article