Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity
Ma, Huifang, Lesné, Sylvain, Kotilinek, Linda, Steidl-Nichols, Jill V, Sherman, Mathew, Younkin, Linda, Younkin, Steven, Forster, Colleen, Sergeant, Nicolas, Delacourte, André, Vassar, Robert, Citron, Martin, Kofuji, Paulo, Boland, Linda M, Ashe, Karen H
Published in Proceedings of the National Academy of Sciences - PNAS (08.05.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (08.05.2007)
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Journal Article
Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment
Wisialowski, Todd A., Ether, Nick, Foley, C. Michael, Kleiman, Robert, Koshman, Yevgeniya, Leishman, Derek, Martel, Eric, Nichols, Jill V., Popp, Julia, Rajamani, Sridharan, Riley, Steve, Rossman, Eric I., Vargas, Hugo M.
Published in Journal of pharmacological and toxicological methods (01.07.2024)
Published in Journal of pharmacological and toxicological methods (01.07.2024)
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Journal Article
Assessment of corrected JT-peak (JTpc) and Tpeak-to-Tend (TpTec) as proarrhythmia biomarkers in non-human primates: Outcome from a HESI consortium
Boulay, Emmanuel, Authier, Simon, Bartko, Theresa, Greiter-Wilke, Andrea, Leishman, Derek, Li, Dingzhou, Nichols, Jill V., Pierson, Jennifer, Rossman, Eric I., Valentin, Jean-Pierre, Vicente, Jose, Walisser, Jacqueline, Troncy, Eric, Wisialowski, Todd A.
Published in Journal of pharmacological and toxicological methods (01.09.2024)
Published in Journal of pharmacological and toxicological methods (01.09.2024)
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Journal Article
Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone
Bartko, Theresa M., Lutgen, Stephen M., Ross, Rebecca A., Walisser, Jacqueline A., Garske, Eric P., Kopelke, Kerry R., Ashcroft-Hawley, Kelly, Tang, Hai-Ming, Kremer, John J., Friedrichs, Gregory S., Nichols, Jill V.
Published in Journal of pharmacological and toxicological methods (01.07.2024)
Published in Journal of pharmacological and toxicological methods (01.07.2024)
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Journal Article
Fluorescently Labeled Analogues of Dofetilide as High-Affinity Fluorescence Polarization Ligands for the Human Ether-a-go-go-Related Gene (hERG) Channel
Singleton, David H, Boyd, Helen, Steidl-Nichols, Jill V, Deacon, Matt, de Groot, Marcel J, Price, David, Nettleton, David O, Wallace, Nora K, Troutman, Matthew D, Williams, Christine, Boyd, James G
Published in Journal of medicinal chemistry (28.06.2007)
Published in Journal of medicinal chemistry (28.06.2007)
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Journal Article
Early evaluation of compound QT prolongation effects: A predictive 384-well fluorescence polarization binding assay for measuring hERG blockade
Deacon, Matt, Singleton, David, Szalkai, Nikki, Pasieczny, Rodger, Peacock, Chris, Price, David, Boyd, James, Boyd, Helen, Steidl-Nichols, Jill V., Williams, Christine
Published in Journal of pharmacological and toxicological methods (2007)
Published in Journal of pharmacological and toxicological methods (2007)
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Journal Article
Impact of study design on proarrhythmia prediction in the SCREENIT rabbit isolated heart model
Steidl-Nichols, Jill V., Hanton, Gilles, Leaney, Joanne, Liu, Ruei-Che, Leishman, Derek, McHarg, Aileen, Wallis, Rob
Published in Journal of pharmacological and toxicological methods (2008)
Published in Journal of pharmacological and toxicological methods (2008)
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Journal Article
Involvement of [beta]-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity
Ma, Huifang, Lesné, Sylvain, Kotilinek, Linda, Steidl-Nichols, Jill V
Published in Proceedings of the National Academy of Sciences - PNAS (08.05.2007)
Get full text
Published in Proceedings of the National Academy of Sciences - PNAS (08.05.2007)
Journal Article
Early evaluation of compound QT prolongation effects: a predictive 384-well fluorescence polarization binding assay for measuring hERG blockade
Deacon, Matt, Singleton, David, Szalkai, Nikki, Pasieczny, Rodger, Peacock, Chris, Price, David, Boyd, James, Boyd, Helen, Steidl-Nichols, Jill V, Williams, Christine
Published in Journal of pharmacological and toxicological methods (01.05.2007)
Get full text
Published in Journal of pharmacological and toxicological methods (01.05.2007)
Journal Article