Search Results - "Ngan, Hextan Yuen Sheung"

Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis by Liao, Xiaoyun, Siu, Michelle Kwan‐Yee, Chan, Kelvin Yuen‐Kwong, Wong, Esther Shuk‐Ying, Ngan, Hextan Yuen‐Sheung, Chan, Queeny Kwan‐Yi, Li, Albert Siu‐Ming, Khoo, Ui‐Soon, Cheung, Annie Nga‐Yin

“…Epigenetic aberration is known to be important in human carcinogenesis. Promoter methylation status of RAS effector related genes, RASSF1A, RASSF2A, hDAB2IP…”

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Ascites-derived ALDH+CD44+ tumour cell subsets endow stemness, metastasis and metabolic switch via PDK4-mediated STAT3/AKT/NF-κB/IL-8 signalling in ovarian cancer by Jiang, Yu-Xin, Siu, Michelle Kwan-Yee, Wang, Jing-Jing, Mo, Xue-Tang, Leung, Thomas Ho-Yin, Chan, David Wai, Cheung, Annie Nga-Yin, Ngan, Hextan Yuen-Sheung, Chan, Karen Kar-Loen

“…Background Ovarian cancer is characterised by frequent recurrence due to persistent presence of residual cancer stem cells (CSCs). Here, we identify and…”

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CD109 mediates tumorigenicity and cancer aggressiveness via regulation of EGFR and STAT3 signalling in cervical squamous cell carcinoma by Mo, Xue-Tang, Leung, Thomas Ho-Yin, Tang, Hermit Wai-Man, Siu, Michelle Kwan-Yee, Wan, Peter Kok-Ting, Chan, Karen Kar-Loen, Cheung, Annie Nga-Yin, Ngan, Hextan Yuen-Sheung

“…Background CD109 was involved in the tumorigenesis and progression of various cancers via TGF-β1 signalling and STAT3 activation. As CD109 is strongly…”

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Trabectedin Plus Pegylated Liposomal Doxorubicin in Recurrent Ovarian Cancer by Monk, Bradley J., Herzog, Thomas J., Kaye, Stanley B., Krasner, Carolyn N., Vermorken, Jan B., Muggia, Franco M., Pujade-Lauraine, Eric, Lisyanskaya, Alla S., Makhson, Anatoly N., Rolski, Janusz, Gorbounova, Vera A., Ghatage, Prafull, Bidzinski, Mariusz, Shen, Keng, Ngan, Hextan Yuen-Sheung, Vergote, Ignace B., Nam, Joo-Hyun, Park, Youn Choi, Lebedinsky, Claudia A., Poveda, Andrés M.

“…The objective of this study was to compare the efficacy and safety of trabectedin plus pegylated liposomal doxorubicin (PLD) with that of PLD alone in women…”

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Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade by Yung, Mingo Ming Ho, Chan, David Wai, Liu, Vincent Wing Sun, Yao, Kwok-Ming, Ngan, Hextan Yuen-Sheung

“…Although advanced-stage cervical cancer can benefit from current treatments, approximately 30% patients may fail after definitive treatment eventually…”

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Methylation-associated silencing of miR-193a-3p promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK/ERK pathways by Chen, Kangmei, Liu, Michelle Xin, Mak, Celia Sze-Ling, Yung, Mingo Ming-Ho, Leung, Thomas Ho-Yin, Xu, Dakang, Ngu, Siew-Fei, Chan, Karen Kar-Loen, Yang, Huijuan, Ngan, Hextan Yuen-Sheung, Chan, David Wai

“…Human growth factor receptor-bound protein-7 (GRB7) is a pivotal mediator involved in receptor tyrosine kinase signaling and governing diverse cellular…”

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Human papillomavirus E6 protein enriches the CD55(+) population in cervical cancer cells, promoting radioresistance and cancer aggressiveness by Leung, Thomas Ho‐Yin, Tang, Hermit Wai‐Man, Siu, Michelle Kwan‐Yee, Chan, David Wai, Chan, Karen Kar‐Loen, Cheung, Annie Nga‐Yin, Ngan, Hextan Yuen‐Sheung

“…Accumulating evidence indicates that the human papillomavirus (HPV) E6 protein plays a crucial role in the development of cervical cancer. Subpopulations of…”

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A Combination of Glutaminase Inhibitor 968 and PD-L1 Blockade Boosts the Immune Response against Ovarian Cancer by Wang, Jing-Jing, Siu, Michelle Kwan-Yee, Jiang, Yu-Xin, Leung, Thomas Ho-Yin, Chan, David Wai, Wang, Huo-Gang, Ngan, Hextan Yuen-Sheung, Chan, Karen Kar-Loen

“…Programmed cell death 1 ligand (PD-L1) blockade has been used therapeutically in the treatment of ovarian cancer, and potential combination treatment…”

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Overexpression of iASPP is required for autophagy in response to oxidative stress in choriocarcinoma by Chan, Ka-Kui, Wong, Esther Shuk-Ying, Wong, Ivy Tsz-Lo, Cheung, Claire Ling-Yang, Wong, Oscar Gee-Wan, Ngan, Hextan Yuen-Sheung, Cheung, Annie Nga-Yin

“…Gestational trophoblastic disease (GTD) is a heterogeneous group of diseases developed from trophoblasts. ASPP (Ankyrin-repeat, SH3-domain and proline-rich…”

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The Value of Four-Quadrant Cervical Biopsy in Women with Different Colposcopic Impressions by Chu, Mandy Man-Yee, Cheung, Charleen Sze-Yan, Ngu, Siew-Fei, Tse, Ka-Yu, Ip, Philip Pun-Ching, Cheung, Annie Nga-Yin, Ngan, Hextan Yuen-Sheung, Chan, Karen Kar-Loen

“…The aim of this study was to compare the diagnostic efficacy of colposcopic-directed biopsy and four-quadrant biopsy in detecting high-grade cervical…”

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Expression of ΔNp73 and TAp73α Independently Associated with Radiosensitivities and Prognoses in Cervical Squamous Cell Carcinoma by Liu, Stephanie Si, Chan, Kelvin Yuen-Kwong, Cheung, Annie Nga-Yin, Liao, Xiao-Yun, Leung, Tsin-Wah, Ngan, Hextan Yuen-Sheung

“…Purpose: The p73 gene produces different protein isoforms using alternative promoters and splicing, which have different biological characteristics. This study…”

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Laparoscopic Non-Mesh Cerclage Pectopexy with Uterine Preservation for Pelvic Organ Prolapse by Lyu, Chaoxia, Cheon, Willy Cecilia, Sheung Ngan, Hextan Yuen, Wei, Yuzhen, Zhang, Wenju

“…Pelvic organ prolapse (POP) affects millions of women globally and carries a significant socioeconomic burden. Adequate apical support is essential for…”

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p73 Expression Is Associated with the Cellular Radiosensitivity in Cervical Cancer after Radiotherapy by Liu, Stephanie Si, Leung, Rebecca Ching-Yu, Chan, Kelvin Yuen-Kwong, Chiu, Pui-Man, Cheung, Annie Nga-Yin, Tam, Kar-Fai, Ng, Tong-Yow, Wong, Ling-Chui, Ngan, Hextan Yuen-Sheung

“…Apoptosis is one of the causes of cell death in cervical cancer following radiotherapy (S. S. Liu et al ., Eur. J. Cancer, 37: 1104–1110, 2001). By studying…”

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HPV-induced Nurr1 promotes cancer aggressiveness, self-renewal, and radioresistance via ERK and AKT signaling in cervical cancer by Wan, Peter Kok-Ting, Leung, Thomas Ho-Yin, Siu, Michelle Kwan-Yee, Mo, Xue-Tang, Tang, Hermit Wai-Man, Chan, Karen Kar-Loen, Cheung, Annie Nga-Yin, Ngan, Hextan Yuen-Sheung

“…Human papillomavirus (HPV) is the etiological agent of cervical cancer; however, the mechanisms underlying HPV-mediated carcinogenesis remain poorly…”

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595 Unraveling ROS-mediated signaling pathways during the development of chemoresistance in ovarian cancer by He, Minjun, Ho yung, Mingo Ming, Yee Siu, Michelle Kwan, Sheung ngan, Hextan Yuen, Chan, David Wai, Loen Chan, Karen Kar

“…Introduction/BackgroundCisplatin-remedial chemotherapy is a widely used treatment for ovarian cancer; however, many patients eventually develop resistance to…”

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GRO-α and IL-8 enhance ovarian cancer metastatic potential via the CXCR2-mediated TAK1/NFκB signaling cascade by Yung, Mingo Ming-Ho, Tang, Hermit Wai-Man, Cai, Patty Chun-Hui, Leung, Thomas Ho-Yin, Ngu, Siew-Fei, Chan, Karen Kar-Loen, Xu, Dakang, Yang, Huijuan, Ngan, Hextan Yuen-Sheung, Chan, David Wai

“…Intraperitoneal metastasis is a common occurrence and is usually involved in the poor prognosis of ovarian cancer. Its specific metastatic pattern implies that…”

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Association between MRI histogram features and treatment response in locally advanced cervical cancer treated by chemoradiotherapy by Perucho, Jose Angelo Udal, Wang, Mandi, Tse, Ka Yu, Ip, Philip Pun Ching, Siu, Steven Wai Kwan, Ngan, Hextan Yuen Sheung, Khong, Pek-Lan, Lee, Elaine Yuen Phin

“…Objective To examine the associations of histogram features of T2-weighted (T2W) images and apparent diffusion coefficient (ADC) with treatment response in…”

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Infiltration of T cells promotes the metastasis of ovarian cancer cells via the modulation of metastasis-related genes and PD-L1 expression by Wang, Jing-Jing, Siu, Michelle Kwan-Yee, Jiang, Yu-Xin, Chan, David Wai, Cheung, Annie Nga-Yin, Ngan, Hextan Yuen-Sheung, Chan, Karen Kar-Loen

“…Due to its high ability to disseminate, ovarian cancer remains one of the largest threats to women’s health, worldwide. Evidence showed that the immune cells…”

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Enhancement of the radiosensitivity of cervical cancer cells by overexpressing p73α by Liu, Stephanie Si, Chan, Kelvin Yuen-Kwong, Leung, Rebecca Ching-Yu, Law, Helen Ka-Wai, Leung, Tsin-Wah, Ngan, Hextan Yuen-Sheung

“…Radiation therapy is the most effective therapy for cervical cancer in advanced stages. p53 plays a critical role in the cellular response to radiation-induced…”

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An Interactive Web-Based Sexual Health Literacy Program for Safe Sex Practice for Female Chinese University Students: Multicenter Randomized Controlled Trial by Wong, Janet Yuen-Ha, Zhang, Wen, Wu, Yongda, Choi, Edmond Pui Hang, Lo, Herman Hay Ming, Wong, Wendy, Chio, Jasmine Hin Man, Tam, Hau Lin Cherry, Ngai, Fei Wan, Tarrant, Marie, Wang, Man Ping, Ngan, Hextan Yuen-Sheung, Fong, Daniel Yee-Tak

“…Sexual health concerns among young adults worldwide help to motivate preventative practices against sexually transmitted infections. To foster better sexual…”

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