Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
Dai, Han, Case, April W., Riera, Thomas V., Considine, Thomas, Lee, Jessica E., Hamuro, Yoshitomo, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Pietrak, Beth, Schwartz, Benjamin, Blum, Charles A., Disch, Jeremy S., Caldwell, Richard, Szczepankiewicz, Bruce, Oalmann, Christopher, Yee Ng, Pui, White, Brian H., Casaubon, Rebecca, Narayan, Radha, Koppetsch, Karsten, Bourbonais, Francis, Wu, Bo, Wang, Junfeng, Qian, Dongming, Jiang, Fan, Mao, Cheney, Wang, Minghui, Hu, Erding, Wu, Joe C., Perni, Robert B., Vlasuk, George P., Ellis, James L.
Published in Nature communications (02.07.2015)
Published in Nature communications (02.07.2015)
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Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
Hubbard, Basil P., Gomes, Ana P., Dai, Han, Li, Jun, Case, April W., Considine, Thomas, Riera, Thomas V., Lee, Jessica E., Yen E, Sook, Lamming, Dudley W., Pentelute, Bradley L., Schuman, Eli R., Stevens, Linda A., Ling, Alvin J. Y., Armour, Sean M., Michan, Shaday, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Blum, Charles A., Disch, Jeremy S., Ng, Pui Yee, Howitz, Konrad T., Rolo, Anabela P., Hamuro, Yoshitomo, Moss, Joel, Perni, Robert B., Ellis, James L., Vlasuk, George P., Sinclair, David A.
Published in Science (American Association for the Advancement of Science) (08.03.2013)
Published in Science (American Association for the Advancement of Science) (08.03.2013)
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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Choy, Wendy, Sinclair, David A, Lambert, Philip D, Gagne, David J, Lynch, Amy V, Milne, Jill C, Bemis, Jean E, Boss, Olivier, Perni, Robert B, Schenk, Simon, Carney, David P, Yang, Hongying, Ng, Pui Yee, Iffland, Andre, Smith, Jesse J, Elliott, Peter J, Vu, Chi B, Xie, Roger, Galonek, Heidi, Israelian, Kristine, Lavu, Siva, Medvedik, Oliver, Olefsky, Jerrold M, Disch, Jeremy S, Nunes, Joseph J, Jirousek, Michael R, Westphal, Christoph H, Jin, Lei
Published in Nature (29.11.2007)
Published in Nature (29.11.2007)
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Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma
Devlin, Jennifer R, Hannan, Katherine M, Hein, Nadine, Cullinane, Carleen, Kusnadi, Eric, Ng, Pui Yee, George, Amee J, Shortt, Jake, Bywater, Megan J, Poortinga, Gretchen, Sanij, Elaine, Kang, Jian, Drygin, Denis, O'Brien, Sean, Johnstone, Ricky W, McArthur, Grant A, Hannan, Ross D, Pearson, Richard B
Published in Cancer discovery (01.01.2016)
Published in Cancer discovery (01.01.2016)
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HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms
Yue, Lanzhu, Sharma, Vasundhara, Horvat, Nathan P., Akuffo, Afua A., Beatty, Matthew S., Murdun, Cem, Colin, Christelle, Billington, Julia M.R., Goodheart, William E., Sahakian, Eva, Zhang, Ling, Powers, John J., Amin, Narmin E., Lambert-Showers, Que T., Darville, Lancia N., Pinilla-Ibarz, Javier, Reuther, Gary W., Wright, Kenneth L., Conti, Chiara, Lee, Jennifer Y., Zheng, Xiaozhang, Ng, Pui Yee, Martin, Matthew W., Marshall, C. Gary, Koomen, John M., Levine, Ross L., Verma, Amit, Grimes, H. Leighton, Sotomayor, Eduardo M., Shao, Zonghong, Epling-Burnette, Pearlie K.
Published in Blood (16.01.2020)
Published in Blood (16.01.2020)
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AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer
Chan, Joanna C, Hannan, Katherine M, Riddell, Kim, Ng, Pui Yee, Peck, Abigail, Lee, Rachel S, Hung, Sandy, Astle, Megan V, Bywater, Megan, Wall, Meaghan, Poortinga, Gretchen, Jastrzebski, Katarzyna, Sheppard, Karen E, Hemmings, Brian A, Hall, Michael N, Johnstone, Ricky W, McArthur, Grant A, Hannan, Ross D, Pearson, Richard B
Published in Science signaling (30.08.2011)
Published in Science signaling (30.08.2011)
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SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging
Blum, Charles A, Ellis, James L, Loh, Christine, Ng, Pui Yee, Perni, Robert B, Stein, Ross L
Published in Journal of medicinal chemistry (27.01.2011)
Published in Journal of medicinal chemistry (27.01.2011)
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Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators
Vu, Chi B, Bemis, Jean E, Disch, Jeremy S, Ng, Pui Yee, Nunes, Joseph J, Milne, Jill C, Carney, David P, Lynch, Amy V, Smith, Jesse J, Lavu, Siva, Lambert, Philip D, Gagne, David J, Jirousek, Michael R, Schenk, Simon, Olefsky, Jerrold M, Perni, Robert B
Published in Journal of medicinal chemistry (12.03.2009)
Published in Journal of medicinal chemistry (12.03.2009)
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Discovery of oxazolo[4,5- b]pyridines and related heterocyclic analogs as novel SIRT1 activators
Bemis, Jean E., Vu, Chi B., Xie, Roger, Nunes, Joseph J., Ng, Pui Yee, Disch, Jeremy S., Milne, Jill C., Carney, David P., Lynch, Amy V., Jin, Lei, Smith, Jesse J., Lavu, Siva, Iffland, Andre, Jirousek, Michael R., Perni, Robert B.
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
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Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11
Martin, Matthew W., Lee, Jennifer Y., Lancia, David R., Ng, Pui Yee, Han, Bingsong, Thomason, Jennifer R., Lynes, Maureen S., Marshall, C. Gary, Conti, Chiara, Collis, Alan, Morales, Monica Alvarez, Doshi, Kshama, Rudnitskaya, Aleksandra, Yao, Lili, Zheng, Xiaozhang
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
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Synthesis of Diverse Lactam Carboxamides Leading to the Discovery of a New Transcription-Factor Inhibitor
Ng, Pui Yee, Tang, Yuchen, Knosp, Wendy M., Stadler, H. Scott, Shaw, Jared T.
Published in Angewandte Chemie (09.07.2007)
Published in Angewandte Chemie (09.07.2007)
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Abstract P229: Pre-clinical evaluation of next-generation inhibitor targeting a wide spectrum of oncogenic BRAF dimers
Han, Yoon-Chi, Ng, Pui Yee, Schulz, Ryan, Yang, Shao Ning, Lelo, Alana, Shin, Luisa, O'Connor, Matthew, Jewett, Ivan, Ishiyama, Noboru, Romashko, Darlene, Thakur, Shalabh, Salomatov, Andrei, Smith, Sherri, Buck, Elizabeth, Roberts, Christopher, Lucas, Matthew, Lin, Tai-An
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Abstract A090: Preclinical efficacy of BDTX-4933, a brain-penetrant, orthosteric RAF inhibitor, targeting oncogenic RAF conformation shared by groups of BRAF and upstream driver mutations
Han, Yoon-Chi, Ng, Pui Yee, Ogawa, Luisa Shin, Yang, Shao Ning, Chen, Miao, Romashko, Darlene, Lin, Tai-An, Buck, Elizabeth
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Abstract 3415: Preclinical characterization of a brain penetrant RAF inhibitor, BDTX-4933, targeting oncogenic BRAF Class I/II/III and RAS mutations
Han, Yoon-Chi, Ng, Pui-Yee, Ogawa, Luisa Shin, Yang, Shao Ning, Chen, Miao, Ishiyama, Noboru, Lin, Tai-An, Buck, Elizabeth
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms
Sharma, Vasundhara, Yue, Lanzhu, Horvat, Nathan P., Christodoulidou, Agni, Akuffo, Afua Adutwumwa, Beatty, Mathew, Murdun, Cem, Billington, Julia, Goodheart, William E, Sahakian, Eva, Zhang, Ling, Powers, John J., Amin, Narmin E., Lambert-Showers, Que T., Darville, Lancia, Pinilla Ibarz, Javier, Reuther, Gary W., Lee, Jennifer, Zheng, Xiaozhang, Yee Ng, Pui, Martin, Mathew W., Marshall, Gary C., Koomen, John M., Levine, Ross L., Verma, Amit, Grimes, H. Leighton, Sotomayor, Eduardo, Shao, Zonghong, Wright, Kenneth, Epling-Burnette, Pearlie K.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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The Enantioselective Allylation and Crotylation of Sterically Hindered and Functionalized Aryl Ketones: Convenient Access to Unusual Tertiary Carbinol Structures
Burns, Noah Z., Hackman, Blaine M., Ng, Pui Yee, Powelson, Ian A., Leighton, James L.
Published in Angewandte Chemie International Edition (02.06.2006)
Published in Angewandte Chemie International Edition (02.06.2006)
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