Novel myostatin-specific antibody enhances muscle strength in muscle disease models
Muramatsu, Hiroyasu, Kuramochi, Taichi, Katada, Hitoshi, Ueyama, Atsunori, Ruike, Yoshinao, Ohmine, Ken, Shida-Kawazoe, Meiri, Miyano-Nishizawa, Rie, Shimizu, Yuichiro, Okuda, Momoko, Hori, Yuji, Hayashi, Madoka, Haraya, Kenta, Ban, Nobuhiro, Nonaka, Tatsuya, Honda, Masaki, Kitamura, Hidetomo, Hattori, Kunihiro, Kitazawa, Takehisa, Igawa, Tomoyuki, Kawabe, Yoshiki, Nezu, Junichi
Published in Scientific reports (25.01.2021)
Published in Scientific reports (25.01.2021)
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Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody
Sampei, Zenjiro, Haraya, Kenta, Tachibana, Tatsuhiko, Fukuzawa, Taku, Shida-Kawazoe, Meiri, Gan, Siok Wan, Shimizu, Yuichiro, Ruike, Yoshinao, Feng, Shu, Kuramochi, Taichi, Muraoka, Masaru, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi
Published in PloS one (28.12.2018)
Published in PloS one (28.12.2018)
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Journal Article
Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases
Fukuzawa, Taku, Sampei, Zenjiro, Haraya, Kenta, Ruike, Yoshinao, Shida-Kawazoe, Meiri, Shimizu, Yuichiro, Gan, Siok Wan, Irie, Machiko, Tsuboi, Yoshinori, Tai, Hitoshi, Sakiyama, Tetsushi, Sakamoto, Akihisa, Ishii, Shinya, Maeda, Atsuhiko, Iwayanagi, Yuki, Shibahara, Norihito, Shibuya, Mitsuko, Nakamura, Genki, Nambu, Takeru, Hayasaka, Akira, Mimoto, Futa, Okura, Yuu, Hori, Yuji, Habu, Kiyoshi, Wada, Manabu, Miura, Takaaki, Tachibana, Tatsuhiko, Honda, Kiyofumi, Tsunoda, Hiroyuki, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi
Published in Scientific reports (24.04.2017)
Published in Scientific reports (24.04.2017)
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Journal Article
Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease
Okura, Yuu, Ikawa-Teranishi, Yuri, Mizoroki, Akihiko, Takahashi, Noriyuki, Tsushima, Takashi, Irie, Machiko, Harfuddin, Zulkarnain, Miura-Okuda, Momoko, Ito, Shunsuke, Nakamura, Genki, Takesue, Hiroaki, Ozono, Yui, Nishihara, Masamichi, Yamada, Kenta, Gan, Siok Wan, Hayasaka, Akira, Ishii, Shinya, Wakabayashi, Tetsuya, Muraoka, Masaru, Nagaya, Nishiki, Hino, Hiroshi, Nemoto, Takayuki, Kuramochi, Taichi, Torizawa, Takuya, Shimada, Hideaki, Kitazawa, Takehisa, Okazaki, Makoto, Nezu, Junichi, Sollid, Ludvig M., Igawa, Tomoyuki
Published in Nature communications (22.12.2023)
Published in Nature communications (22.12.2023)
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Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering
Hori, Yuji, Ohmine, Ken, Katada, Hitoshi, Noguchi, Yuki, Sato, Kazuki, Nambu, Takeru, Adeline, Lam Runyi, Wan, Gan Siok, Haraya, Kenta, Ozeki, Kazuhisa, Nanami, Masahiko, Tachibana, Tatsuhiko, Sampei, Zenjiro, Kuramochi, Taichi, Nezu, Junichi, Hattori, Kunihiro, Igawa, Tomoyuki
Published in mAbs (2022)
Published in mAbs (2022)
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Journal Article
Development of Tetravalent, Bispecific CCR5 Antibodies with Antiviral Activity against CCR5 Monoclonal Antibody-Resistant HIV-1 Strains
Schanzer, Jürgen, Jekle, Andreas, Nezu, Junichi, Lochner, Adriane, Croasdale, Rebecca, Dioszegi, Marianna, Zhang, Jun, Hoffmann, Eike, Dormeyer, Wilma, Stracke, Jan, Schäfer, Wolfgang, Ji, Changhua, Heilek, Gabrielle, Cammack, Nick, Brandt, Michael, Umana, Pablo, Brinkmann, Ulrich
Published in Antimicrobial Agents and Chemotherapy (01.05.2011)
Published in Antimicrobial Agents and Chemotherapy (01.05.2011)
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Complement Activation by an Anti-Dengue/Zika Antibody with Impaired Fcγ Receptor Binding Provides Strong Efficacy and Abrogates Risk of Antibody-Dependent Enhancement
Sampei, Zenjiro, Koo, Christine Xing'er, Teo, Frannie Jiuyi, Toh, Ying Xiu, Fukuzawa, Taku, Gan, Siok Wan, Nambu, Takeru, Ho, Adrian, Honda, Kiyofumi, Igawa, Tomoyuki, Ahmed, Fariyal, Wang, Cheng-I, Fink, Katja, Nezu, Junichi
Published in Antibodies (Basel) (15.05.2023)
Published in Antibodies (Basel) (15.05.2023)
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PK/PD analysis of a novel pH-dependent antigen-binding antibody using a dynamic antibody–antigen binding model
Haraya, Kenta, Tachibana, Tatsuhiko, Iwayanagi, Yuki, Maeda, Atsuhiko, Ozeki, Kazuhisa, Nezu, Junichi, Ishigai, Masaki, Igawa, Tomoyuki
Published in Drug metabolism and pharmacokinetics (01.04.2016)
Published in Drug metabolism and pharmacokinetics (01.04.2016)
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Journal Article
An anti-glypican 3/CD3 bispecific T cell-redirecting antibody for treatment of solid tumors
Ishiguro, Takahiro, Sano, Yuji, Komatsu, Shun-Ichiro, Kamata-Sakurai, Mika, Kaneko, Akihisa, Kinoshita, Yasuko, Shiraiwa, Hirotake, Azuma, Yumiko, Tsunenari, Toshiaki, Kayukawa, Yoko, Sonobe, Yukiko, Ono, Natsuki, Sakata, Kiyoaki, Fujii, Toshihiko, Miyazaki, Yoko, Noguchi, Mizuho, Endo, Mika, Harada, Asako, Frings, Werner, Fujii, Etsuko, Nanba, Eitaro, Narita, Atsushi, Sakamoto, Akihisa, Wakabayashi, Tetsuya, Konishi, Hiroko, Segawa, Hiroaki, Igawa, Tomoyuki, Tsushima, Takashi, Mutoh, Hironori, Nishito, Yukari, Takahashi, Mina, Stewart, Lorraine, ElGabry, Ehab, Kawabe, Yoshiki, Ishigai, Masaki, Chiba, Shuichi, Aoki, Masahiro, Hattori, Kunihiro, Nezu, Junichi
Published in Science translational medicine (04.10.2017)
Published in Science translational medicine (04.10.2017)
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Engineering a bispecific antibody with a common light chain: Identification and optimization of an anti-CD3 epsilon and anti-GPC3 bispecific antibody, ERY974
Shiraiwa, Hirotake, Narita, Atsushi, Kamata-Sakurai, Mika, Ishiguro, Takahiro, Sano, Yuji, Hironiwa, Naoka, Tsushima, Takashi, Segawa, Hiroaki, Tsunenari, Toshiaki, Ikeda, Yosuke, Kayukawa, Yoko, Noguchi, Mizuho, Wakabayashi, Tetsuya, Sakamoto, Akihisa, Konishi, Hiroko, Kuramochi, Taichi, Endo, Mika, Hattori, Kunihiro, Nezu, Junichi, Igawa, Tomoyuki
Published in Methods (San Diego, Calif.) (01.02.2019)
Published in Methods (San Diego, Calif.) (01.02.2019)
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Journal Article
CYTOTOXIC INDUCTION THERAPEUTIC AGENT
ISHIGURO TAKAHIRO, NEZU JUNICHI, SHIRAIWA HIROTAKE, IGAWA TOMOYUKI, HIRONIWA NAOKA, NARITA ATSUSHI, SAKURAI MIKA, KAWAI YUMIKO
Year of Publication 05.03.2024
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Year of Publication 05.03.2024
Patent
Cytotoxicity-inducing therapeutic agent
ISHIGURO TAKAHIRO, KURAMOCHI TAICHI, NEZU JUNICHI, SAKAMOTO AKIHISA, IGAWA TOMOYUKI, NARITA ATSUSHI, KAWAI YUMIKO
Year of Publication 26.02.2024
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Year of Publication 26.02.2024
Patent
Abstract 2378: Differential exhaustion on cytokine release (DECREASE) by ERY974, a novel T-cell-redirecting antibody targeting glypican-3: A new type of T-cell exhaustion
Hoshino, Mayumi, Sano, Yuji, Kinoshita, Yasuko, Azuma, Yumiko, Tsunenari, Toshiaki, Kayukawa, Yoko, Noguchi, Mizuho, Ishiguro, Takahiro, Kishishita, Shohei, Sawada, Noriaki, Endo, Mika, Nezu, Junichi
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
SKY59: A Long-Lasting Engineered Anti-C5 Antibody for Subcutaneously Injectable Anti-Complement Therapy
Haraya, Kenta, Sampei, Zenjiro, Tachibana, Tatsuhiko, Fukuzawa, Taku, Gan, Siok Wan, Shida-Kawazoe, Meiri, Shimizu, Yuichiro, Muraoka, Masaru, Igawa, Tomoyuki, Kitazawa, Takehisa, Nezu, Junichi
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
CYTOTOXICITY-INDUCING THERAPEUTIC AGENTS
ISHIGURO TAKAHIRO, KURAMOCHI TAICHI, NEZU JUNICHI, SAKAMOTO AKIHISA, IGAWA TOMOYUKI, NARITA ATSUSHI, KAWAI YUMIKO
Year of Publication 18.08.2023
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Year of Publication 18.08.2023
Patent
CYTOTOXICITY-INDUCING THERAPEUTIC AGENT
ISHIGURO TAKAHIRO, NEZU JUNICHI, SHIRAIWA HIROTAKE, IGAWA TOMOYUKI, HIRONIWA NAOKA, NARITA ATSUSHI, SAKURAI MIKA, KAWAI YUMIKO
Year of Publication 06.07.2023
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Year of Publication 06.07.2023
Patent
Abstract 5609: ERY974, a novel T cell-redirecting bispecific antibody targeting glypican-3, shows antitumor activity in gastric cancer patient-derived xenograft models with varying glypican-3 expression
Yumiko, Azuma, Sano, Yuji, Tsunenari, Toshiaki, Kinoshita, Yasuko, Miyazaki, Yoko, Shinozuka, Junko, Fujii, Etsuko, Kato, Atsuhiko, Ishiguro, Takahiro, Kishishita, Shohei, Nezu, Junichi, Kawabe, Yoshiki, Endo, Mika
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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