A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate
Newton, Phillip T., Li, Lei, Zhou, Baoyi, Schweingruber, Christoph, Hovorakova, Maria, Xie, Meng, Sun, Xiaoyan, Sandhow, Lakshmi, Artemov, Artem V., Ivashkin, Evgeny, Suter, Simon, Dyachuk, Vyacheslav, El Shahawy, Maha, Gritli-Linde, Amel, Bouderlique, Thibault, Petersen, Julian, Mollbrink, Annelie, Lundeberg, Joakim, Enikolopov, Grigori, Qian, Hong, Fried, Kaj, Kasper, Maria, Hedlund, Eva, Adameyko, Igor, Sävendahl, Lars, Chagin, Andrei S.
Published in Nature (London) (01.03.2019)
Published in Nature (London) (01.03.2019)
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Journal Article
Targeted Deletion of Autophagy Genes Atg5 or Atg7 in the Chondrocytes Promotes Caspase‐Dependent Cell Death and Leads to Mild Growth Retardation
Vuppalapati, Karuna K, Bouderlique, Thibault, Newton, Phillip T, Kaminskyy, Vitaliy O, Wehtje, Henrik, Ohlsson, Claes, Zhivotovsky, Boris, Chagin, Andrei S
Published in Journal of bone and mineral research (01.12.2015)
Published in Journal of bone and mineral research (01.12.2015)
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Journal Article
Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice
Li, Lei, Newton, Phillip T, Bouderlique, Thibault, Sejnohova, Marie, Zikmund, Tomas, Kozhemyakina, Elena, Xie, Meng, Krivanek, Jan, Kaiser, Jozef, Qian, Hong, Dyachuk, Vyacheslav, Lassar, Andrew B, Warman, Matthew L, Barenius, Björn, Adameyko, Igor, Chagin, Andrei S
Published in The FASEB journal (01.03.2017)
Published in The FASEB journal (01.03.2017)
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Journal Article
Spatially resolved transcriptomic profiling of degraded and challenging fresh frozen samples
Mirzazadeh, Reza, Andrusivova, Zaneta, Larsson, Ludvig, Newton, Phillip T., Galicia, Leire Alonso, Abalo, Xesús M., Avijgan, Mahtab, Kvastad, Linda, Denadai-Souza, Alexandre, Stakenborg, Nathalie, Firsova, Alexandra B., Shamikh, Alia, Jurek, Aleksandra, Schultz, Niklas, Nistér, Monica, Samakovlis, Christos, Boeckxstaens, Guy, Lundeberg, Joakim
Published in Nature communications (2023)
Published in Nature communications (2023)
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Journal Article
The level of protein in the maternal murine diet modulates the facial appearance of the offspring via mTORC1 signaling
Xie, Meng, Kaiser, Markéta, Gershtein, Yaakov, Schnyder, Daniela, Deviatiiarov, Ruslan, Gazizova, Guzel, Shagimardanova, Elena, Zikmund, Tomáš, Kerckhofs, Greet, Ivashkin, Evgeny, Batkovskyte, Dominyka, Newton, Phillip T., Andersson, Olov, Fried, Kaj, Gusev, Oleg, Zeberg, Hugo, Kaiser, Jozef, Adameyko, Igor, Chagin, Andrei S.
Published in Nature communications (26.03.2024)
Published in Nature communications (26.03.2024)
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Journal Article
Niches for Skeletal Stem Cells of Mesenchymal Origin
Kurenkova, Anastasiia D., Medvedeva, Ekaterina V., Newton, Phillip T., Chagin, Andrei S.
Published in Frontiers in cell and developmental biology (10.07.2020)
Published in Frontiers in cell and developmental biology (10.07.2020)
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Journal Article
Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration
Kaucka, Marketa, Joven Araus, Alberto, Tesarova, Marketa, Currie, Joshua D., Boström, Johan, Kavkova, Michaela, Petersen, Julian, Yao, Zeyu, Bouchnita, Anass, Hellander, Andreas, Zikmund, Tomas, Elewa, Ahmed, Newton, Phillip T., Fei, Ji-Feng, Chagin, Andrei S., Fried, Kaj, Tanaka, Elly M., Kaiser, Jozef, Simon, András, Adameyko, Igor
Published in Nature communications (14.11.2022)
Published in Nature communications (14.11.2022)
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Journal Article
Secondary ossification center induces and protects growth plate structure
Xie, Meng, Gol'din, Pavel, Herdina, Anna Nele, Estefa, Jordi, Medvedeva, Ekaterina V, Li, Lei, Newton, Phillip T, Kotova, Svetlana, Shavkuta, Boris, Saxena, Aditya, Shumate, Lauren T, Metscher, Brian D, Großschmidt, Karl, Nishimori, Shigeki, Akovantseva, Anastasia, Usanova, Anna P, Kurenkova, Anastasiia D, Kumar, Anoop, Arregui, Irene Linares, Tafforeau, Paul, Fried, Kaj, Carlström, Mattias, Simon, András, Gasser, Christian, Kronenberg, Henry M, Bastepe, Murat, Cooper, Kimberly L, Timashev, Peter, Sanchez, Sophie, Adameyko, Igor, Eriksson, Anders, Chagin, Andrei S
Published in eLife (16.10.2020)
Published in eLife (16.10.2020)
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Journal Article
Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice
Terrando, Niccolò, Yang, Ting, Ryu, Jae Kyu, Newton, Phillip T, Monaco, Claudia, Feldmann, Marc, Ma, Daqing, Akassoglou, Katerina, Maze, Mervyn
Published in Molecular medicine (Cambridge, Mass.) (2014)
Published in Molecular medicine (Cambridge, Mass.) (2014)
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Journal Article
Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage
Kaucka, Marketa, Zikmund, Tomas, Tesarova, Marketa, Gyllborg, Daniel, Hellander, Andreas, Jaros, Josef, Kaiser, Jozef, Petersen, Julian, Szarowska, Bara, Newton, Phillip T, Dyachuk, Vyacheslav, Li, Lei, Qian, Hong, Johansson, Anne-Sofie, Mishina, Yuji, Currie, Joshua D, Tanaka, Elly M, Erickson, Alek, Dudley, Andrew, Brismar, Hjalmar, Southam, Paul, Coen, Enrico, Chen, Min, Weinstein, Lee S, Hampl, Ales, Arenas, Ernest, Chagin, Andrei S, Fried, Kaj, Adameyko, Igor
Published in eLife (17.04.2017)
Published in eLife (17.04.2017)
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Journal Article
A protocol to differentiate the chondrogenic ATDC5 cell‐line for the collection of chondrocyte‐derived extracellular vesicles
Marchan‐Alvarez, Jose G., Teeuwen, Loes, Mamand, Doste R., Gabrielsson, Susanne, Blomgren, Klas, Wiklander, Oscar P. B., Newton, Phillip T.
Published in Journal of extracellular biology (01.09.2024)
Published in Journal of extracellular biology (01.09.2024)
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Journal Article
Activation of mTORC1 in chondrocytes does not affect proliferation or differentiation, but causes the resting zone of the growth plate to become disordered
Newton, Phillip T., Xie, Meng, Medvedeva, Ekaterina V., Sävendahl, Lars, Chagin, Andrei S.
Published in Bone Reports (01.06.2018)
Published in Bone Reports (01.06.2018)
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Journal Article
Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes bone length, regulates cortical and trabecular bone mass, and maintains growth plate architecture and width in a sex- and site-specific manner in mice
Rathod, Bhavik, Desai, Suchita, Samvelyan, Hasmik Jasmine, Bock, Laura, Wu, Jianyao, Ohlsson, Claes, Palmquist, Anders, Alm, Jessica J., Newton, Phillip T., Andersson, Göran, Windahl, Sara H.
Published in Bone (New York, N.Y.) (01.11.2024)
Published in Bone (New York, N.Y.) (01.11.2024)
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Journal Article
Absence of GP130 cytokine receptor signaling causes extended Stüve-Wiedemann syndrome
Chen, Yin-Huai, Grigelioniene, Giedre, Newton, Phillip T, Gullander, Jacob, Elfving, Maria, Hammarsjö, Anna, Batkovskyte, Dominyka, Alsaif, Hessa S, Kurdi, Wesam I Y, Abdulwahab, Firdous, Shanmugasundaram, Veerabahu, Devey, Luke, Bacrot, Séverine, Brodszki, Jana, Huber, Celine, Hamel, Ben, Gisselsson, David, Papadogiannakis, Nikos, Jedrycha, Katarina, Gürtl-Lackner, Barbara, Chagin, Andrei S, Nishimura, Gen, Aschenbrenner, Dominik, Alkuraya, Fowzan S, Laurence, Arian, Cormier-Daire, Valérie, Uhlig, Holm H
Published in The Journal of experimental medicine (02.03.2020)
Published in The Journal of experimental medicine (02.03.2020)
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Journal Article
Clonal Genetic Tracing using the Confetti Mouse to Study Mineralized Tissues
Zhou, Baoyi, Kaucka, Marketa, Chagin, Andrei S, Newton, Phillip T
Published in Journal of visualized experiments (23.10.2019)
Published in Journal of visualized experiments (23.10.2019)
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Journal Article
Clonal Genetic Tracing using the Confetti Mouse to Study Mineralized Tissues
Zhou, Baoyi, Kaucka, Marketa, Chagin, Andrei S., Newton, Phillip T.
Published in Journal of visualized experiments (23.10.2019)
Published in Journal of visualized experiments (23.10.2019)
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Journal Article