Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo
MILLS, Scott D, EAKIN, Ann E, WEI YANG, STOKES, Suzanne S, BUURMAN, Ed T, NEWMAN, Joseph V, NING GAO, HUYNH, Hoan, JOHNSON, Kenneth D, LAHIRI, Sushmita, SHAPIRO, Adam B, WALKUP, Grant K
Published in Antimicrobial Agents and Chemotherapy (01.03.2011)
Published in Antimicrobial Agents and Chemotherapy (01.03.2011)
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Secreted Gaussia princeps luciferase as a reporter of Escherichia coli replication in a mouse tissue cage model of infection
Liu, Mingyu, Blinn, Christina, McLeod, Sarah M, Wiseman, John W, Newman, Joseph V, Fisher, Stewart L, Walkup, Grant K
Published in PloS one (04.03.2014)
Published in PloS one (04.03.2014)
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Targeted transcriptional downregulation of MYC using epigenomic controllers demonstrates antitumor activity in hepatocellular carcinoma models
Senapedis, William, Gallagher, Kayleigh M, Figueroa, Elmer, Farelli, Jeremiah D, Lyng, Robert, Hodgson, J. Graeme, O’Donnell, Charles W, Newman, Joseph V, Pacaro, Madison, Siecinski, Stephen K, Chen, Justin, McCauley, Thomas G
Published in Nature communications (16.09.2024)
Published in Nature communications (16.09.2024)
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Assessment of in vivo efficacy of eravacycline against Enterobacteriaceae exhibiting various resistance mechanisms: a dose-ranging study and pharmacokinetic/pharmacodynamic analysis
Thabit, Abrar K., Monogue, Marguerite L., Newman, Joseph V., Nicolau, David P.
Published in International journal of antimicrobial agents (01.05.2018)
Published in International journal of antimicrobial agents (01.05.2018)
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ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii
Durand-Réville, Thomas F, Guler, Satenig, Comita-Prevoir, Janelle, Chen, Brendan, Bifulco, Neil, Huynh, Hoan, Lahiri, Sushmita, Shapiro, Adam B, McLeod, Sarah M, Carter, Nicole M, Moussa, Samir H, Velez-Vega, Camilo, Olivier, Nelson B, McLaughlin, Robert, Gao, Ning, Thresher, Jason, Palmer, Tiffany, Andrews, Beth, Giacobbe, Robert A, Newman, Joseph V, Ehmann, David E, de Jonge, Boudewijn, O'Donnell, John, Mueller, John P, Tommasi, Rubén A, Miller, Alita A
Published in Nature microbiology (30.06.2017)
Published in Nature microbiology (30.06.2017)
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Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases
Basarab, Gregory S, Kern, Gunther H, McNulty, John, Mueller, John P, Lawrence, Kenneth, Vishwanathan, Karthick, Alm, Richard A, Barvian, Kevin, Doig, Peter, Galullo, Vincent, Gardner, Humphrey, Gowravaram, Madhusudhan, Huband, Michael, Kimzey, Amy, Morningstar, Marshall, Kutschke, Amy, Lahiri, Sushmita D, Perros, Manos, Singh, Renu, Schuck, Virna J A, Tommasi, Ruben, Walkup, Grant, Newman, Joseph V
Published in Scientific reports (14.07.2015)
Published in Scientific reports (14.07.2015)
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NBTI 5463 Is a Novel Bacterial Type II Topoisomerase Inhibitor with Activity against Gram-Negative Bacteria and In Vivo Efficacy
DOUGHERTY, Thomas J, NAYAR, Asha, NEWMAN, Joseph V, HOPKINS, Sussie, STONE, Gregory G, JOHNSTONE, Michele, SHAPIRO, Adam B, CRONIN, Mark, RECK, Folkert, EHMANN, David E
Published in Antimicrobial agents and chemotherapy (01.05.2014)
Published in Antimicrobial agents and chemotherapy (01.05.2014)
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Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pK a: Antibacterial Agents with an Improved Safety Profile
Reck, Folkert, Alm, Richard A, Brassil, Patrick, Newman, Joseph V, Ciaccio, Paul, McNulty, John, Barthlow, Herbert, Goteti, Kosalaram, Breen, John, Comita-Prevoir, Janelle, Cronin, Mark, Ehmann, David E, Geng, Bolin, Godfrey, Andrew Aydon, Fisher, Stewart L
Published in Journal of medicinal chemistry (09.08.2012)
Published in Journal of medicinal chemistry (09.08.2012)
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Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region
Kawatkar, Sameer P, Keating, Thomas A, Olivier, Nelson B, Breen, John N, Green, Oluyinka M, Guler, Satenig Y, Hentemann, Martin F, Loch, James T, McKenzie, Andrew R, Newman, Joseph V, Otterson, Linda G, Martínez-Botella, Gabriel
Published in Journal of medicinal chemistry (12.06.2014)
Published in Journal of medicinal chemistry (12.06.2014)
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Enteropathogenic Escherichia coli and Ulcerative Colitis in Cotton-Top Tamarins (Saguinus oedipus)
Mansfield, Keith G., Lin, Kuei-Chin, Xia, Dongling, Newman, Joseph V., Schauer, David B., MacKey, John, Lackner, Andrew A., Carville, Angela
Published in The Journal of infectious diseases (15.09.2001)
Published in The Journal of infectious diseases (15.09.2001)
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Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa
Reck, Folkert, Ehmann, David E., Dougherty, Thomas J., Newman, Joseph V., Hopkins, Sussie, Stone, Gregory, Agrawal, Nikunj, Ciaccio, Paul, McNulty, John, Barthlow, Herbert, O’Donnell, Jennifer, Goteti, Kosalaram, Breen, John, Comita-Prevoir, Janelle, Cornebise, Mark, Cronin, Mark, Eyermann, Charles J., Geng, Bolin, Carr, Greg R., Pandarinathan, Lakshmipathi, Tang, Xuejun, Cottone, Andrew, Zhao, Liang, Bezdenejnih-Snyder, Natascha
Published in Bioorganic & medicinal chemistry (01.10.2014)
Published in Bioorganic & medicinal chemistry (01.10.2014)
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Pyridodiazepine amines are selective therapeutic agents for helicobacter pylori by suppressing growth through inhibition of glutamate racemase but are predicted to require continuous elevated levels in plasma to achieve clinical efficacy
de Jonge, Boudewijn L M, Kutschke, Amy, Newman, Joseph V, Rooney, Michael T, Yang, Wei, Cederberg, Christer
Published in Antimicrobial agents and chemotherapy (01.04.2015)
Published in Antimicrobial agents and chemotherapy (01.04.2015)
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Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK)
Martínez-Botella, Gabriel, Breen, John N, Duffy, James E. S, Dumas, Jacques, Geng, Bolin, Gowers, Ian K, Green, Oluyinka M, Guler, Satenig, Hentemann, Martin F, Hernandez-Juan, Felix A, Joseph-McCarthy, Diane, Kawatkar, Sameer, Larsen, Nicholas A, Lazari, Ovadia, Loch, James T, Macritchie, Jacqueline A, McKenzie, Andrew R, Newman, Joseph V, Olivier, Nelson B, Otterson, Linda G, Owens, Andrew P, Read, Jon, Sheppard, David W, Keating, Thomas A
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
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Journal Article
NBTI 5463 Is a Novel Bacterial Type II Topoisomerase Inhibitor with Activity against Gram-Negative Bacteria and In Vivo Efficacy
Dougherty, Thomas J, Nayar, Asha, Newman, Joseph V, Hopkins, Sussie, Stone, Gregory G, Johnstone, Michele, Shapiro, Adam B, Cronin, Mark, Reck, Folkert, Ehmann, David E
Published in Antimicrobial agents and chemotherapy (01.07.2014)
Published in Antimicrobial agents and chemotherapy (01.07.2014)
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In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound
Keating, Thomas A, Newman, Joseph V, Olivier, Nelson B, Otterson, Linda G, Andrews, Beth, Boriack-Sjodin, P. Ann, Breen, John N, Doig, Peter, Dumas, Jacques, Gangl, Eric, Green, Oluyinka M, Guler, Satenig Y, Hentemann, Martin F, Joseph-McCarthy, Diane, Kawatkar, Sameer, Kutschke, Amy, Loch, James T, McKenzie, Andrew R, Pradeepan, Selvi, Prasad, Swati, Martínez-Botella, Gabriel
Published in ACS chemical biology (16.11.2012)
Published in ACS chemical biology (16.11.2012)
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Discovery of bacterial NAD+-dependent DNA ligase inhibitors: Improvements in clearance of adenosine series
Stokes, Suzanne S., Gowravaram, Madhusudhan, Huynh, Hoan, Lu, Min, Mullen, George B., Chen, Brendan, Albert, Robert, O’Shea, Thomas J., Rooney, Michael T., Hu, Haiqing, Newman, Joseph V., Mills, Scott D.
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Bacterial Infection Promotes Colon Tumorigenesis in$Apc^{Min/+}$Mice
Newman, Joseph V., Kosaka, Takeo, Sheppard, Barbara J., Fox, James G., Schauer, David B.
Published in The Journal of infectious diseases (15.07.2001)
Published in The Journal of infectious diseases (15.07.2001)
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Citrobacter rodentium, the causative agent of transmissible murine colonic hyperplasia, exhibits clonality : Synonymy of C. rodentium and mouse-pathogenic Escherichia coli
LUPERCHIO, Steven A, NEWMAN, Joseph V, DANGLER, Charles A, SCHRENZEL, Mark D, BRENNER, Don J, STEIGERWALT, Arnold G, SCHAUER, David B
Published in Journal of clinical microbiology (01.12.2000)
Published in Journal of clinical microbiology (01.12.2000)
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