Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists
Keenan, Richard M, Callahan, James F, Samanen, James M, Bondinell, William E, Calvo, Raul R, Chen, Lichong, DeBrosse, Charles, Eggleston, Drake S, Haltiwanger, R. Curtis, Hwang, Shing Mei, Jakas, Dalia R, Ku, Thomas W, Miller, William H, Newlander, Kenneth A, Nichols, Andrew, Parker, Michael F, Southhall, Linda S, Uzinskas, Irene, Vasko-Moser, Janice A, Venslavsky, Joseph W, Wong, Angela S, Huffman, William F
Published in Journal of medicinal chemistry (25.02.1999)
Published in Journal of medicinal chemistry (25.02.1999)
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Preclinical Pharmacokinetics and Interspecies Scaling of a Novel Vitronectin Receptor Antagonist
WARD, K. W, AZZARANO, L. M, MUMAW, J. A, NEWLANDER, K. A, PIRHALLA, J. L, ROETHKE, T. J, SALYERS, K. L, SOUDER, P. R, STELMAN, G. J, SMITH, B. R, BONDINELL, W. E, COUSINS, R. D, HUFFMAN, W. F, JAKAS, D. R, KEENAN, R. M, KU, T. W, LUNDBERG, D, MILLER, W. H
Published in Drug metabolism and disposition (01.11.1999)
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Published in Drug metabolism and disposition (01.11.1999)
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A Check on Rational Drug Design: Crystal Structure of a Complex of Human Immunodeficiency Virus Type 1 Protease with a Novel .gamma.-Turn Mimetic Inhibitor
Hoog, Susan S, Zhao, Baoguang, Winborne, Evon, Fisher, Seth, Green, David W, DesJarlais, Renee L, Newlander, Kenneth A, Callahan, James F, Abdel-Meguid, Sherin S, Moore, Michael L, Huffman, William F
Published in Journal of medicinal chemistry (01.08.1995)
Published in Journal of medicinal chemistry (01.08.1995)
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A novel constrained reduced-amide inhibitor of HIV-1 protease derived from the sequential incorporation of .gamma.-turn mimetics into a model substrate
Newlander, Kenneth A, Callahan, James F, Moore, Michael L, Tomaszek, Thaddeus A, Huffman, William F
Published in Journal of medicinal chemistry (06.08.1993)
Published in Journal of medicinal chemistry (06.08.1993)
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Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists
Samanen, James M, Ali, Fadia E, Barton, Linda S, Bondinell, William E, Burgess, Joelle L, Callahan, James F, Calvo, Raul R, Chen, Wenting, Chen, Lichong, Erhard, Karl, Feuerstein, Giora, Heys, Richard, Hwang, Shing-Mei, Jakas, Dalia R, Keenan, Richard M, Ku, Thomas W, Kwon, Chet, Lee, Chao-Pin, Miller, William H, Newlander, Kenneth A, Nichols, Andrew, Parker, Michael, Peishoff, Catherine E, Rhodes, Gerald, Ross, Steven, Shu, Arthur, Simpson, Richard, Takata, Dennis, Yellin, Tobias O, Uzsinskas, Irene, Venslavsky, Joseph W, Yuan, Chuan-Kui, Huffman, William F
Published in Journal of medicinal chemistry (06.12.1996)
Published in Journal of medicinal chemistry (06.12.1996)
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Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4- b]indoles as potential antibacterial agents
Seefeld, Mark A, Miller, William H, Newlander, Kenneth A, Burgess, Walter J, Payne, David J, Rittenhouse, Stephen F, Moore, Terrance D, DeWolf, Walter E, Keller, Paul M, Qiu, Xiayang, Janson, Cheryl A, Vaidya, Kalindi, Fosberry, Andrew P, Smyth, Martin G, Jaworski, Deborah D, Slater-Radosti, Courtney, Huffman, William F
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model
Miller, William H., Bondinell, William E., Cousins, Russell D., Erhard, Karl F., Jakas, Dalia R., Keenan, Richard M., Ku, Thomas W., Newlander, Kenneth A., Ross, Stephen T., Haltiwanger, R.Curtis, Bradbeer, Jeremy, Drake, Fred H., Gowen, Maxine, Hoffman, Sandra J., Hwang, Shing-Mei, James, Ian E., Lark, Michael W., Lechowska, Beata, Rieman, David J., Stroup, George B., Vasko-Moser, Janice A., Zembryki, Denise L., Azzarano, Leonard M., Adams, Paula C., Salyers, Kevin L., Smith, Brian R., Ward, Keith W., Johanson, Kyung O., Huffaman, William F.
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
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Design and Characterization of Orally Active Arg-Gly-Asp Peptidomimetic Vitronectin Receptor Antagonist SB 265123 for Prevention of Bone Loss in Osteoporosis
Lark, M W, Stroup, G B, Hwang, S M, James, I E, Rieman, D J, Drake, F H, Bradbeer, J N, Mathur, A, Erhard, K F, Newlander, K A, Ross, S T, Salyers, K L, Smith, B R, Miller, W H, Huffman, W F, Gowen, M
Published in The Journal of pharmacology and experimental therapeutics (01.11.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.11.1999)
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A minor modification of residue 1 in potent vasopressin antagonists dramatically reduces agonist activity
Huffman, William F, Albrightson-Winslow, Christine, Brickson, Bridget, Bryan, Heidemarie G, Caldwell, Nancy, Dytko, George, Eggleston, Drake S, Kinter, Lewis B, Moore, Michael L
Published in Journal of medicinal chemistry (01.04.1989)
Published in Journal of medicinal chemistry (01.04.1989)
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Dicarbavasopressin antagonist analogs exhibit reduced in vivo agonist activity
Moore, Michael L, Albrightson, Christine, Brickson, Bridget, Bryan, Heidemarie G, Caldwell, Nancy, Callahan, James F, Foster, Jonathan, Kinter, Lewis B, Newlander, Kenneth A
Published in Journal of medicinal chemistry (01.08.1988)
Published in Journal of medicinal chemistry (01.08.1988)
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Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic
Miller, William H, Alberts, Doreen P, Bhatnagar, Pradip K, Bondinell, William E, Callahan, James F, Calvo, Raul R, Cousins, Russell D, Erhard, Karl F, Heerding, Dirk A, Keenan, Richard M, Kwon, Chet, Manley, Peter J, Newlander, Kenneth A, Ross, Stephen T, Samanen, James M, Uzinskas, Irene N, Venslavsky, Joseph W, Yuan, Catherine C.-K, Haltiwanger, R. Curtis, Gowen, Maxine, Hwang, Shing-Mei, James, Ian E, Lark, Michael W, Rieman, David J, Stroup, George B, Azzarano, Leonard M, Salyers, Kevin L, Smith, Brian R, Ward, Keith W, Johanson, Kyung O, Huffman, William F
Published in Journal of medicinal chemistry (13.01.2000)
Published in Journal of medicinal chemistry (13.01.2000)
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Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK
Seefeld, Mark A, Miller, William H, Newlander, Kenneth A, Burgess, Walter J, DeWolf, Walter E, Elkins, Patricia A, Head, Martha S, Jakas, Dalia R, Janson, Cheryl A, Keller, Paul M, Manley, Peter J, Moore, Terrance D, Payne, David J, Pearson, Stewart, Polizzi, Brian J, Qiu, Xiayang, Rittenhouse, Stephen F, Uzinskas, Irene N, Wallis, Nicola G, Huffman, William F
Published in Journal of medicinal chemistry (24.04.2003)
Published in Journal of medicinal chemistry (24.04.2003)
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Synthesis of 6,6-pentamethylene-2-aminosuberic acid. A key intermediate in the synthesis of dicarba analogs of vasopressin antagonists
Callahan, James F, Newlander, Kenneth A, Bryan, Heidemarie G, Huffman, William F, Moore, Michael L, Yim, Nelson C. F
Published in Journal of organic chemistry (01.04.1988)
Published in Journal of organic chemistry (01.04.1988)
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Discovery of Aminopyridine-Based Inhibitors of Bacterial Enoyl-ACP Reductase (FabI)
Miller, William H, Seefeld, Mark A, Newlander, Kenneth A, Uzinskas, Irene N, Burgess, Walter J, Heerding, Dirk A, Yuan, Catherine C. K, Head, Martha S, Payne, David J, Rittenhouse, Stephen F, Moore, Terrance D, Pearson, Stewart C, Berry, Valerie, DeWolf, Walter E, Keller, Paul M, Polizzi, Brian J, Qiu, Xiayang, Janson, Cheryl A, Huffman, William F
Published in Journal of medicinal chemistry (18.07.2002)
Published in Journal of medicinal chemistry (18.07.2002)
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Direct design of a potent non-peptide fibrinogen receptor antagonist based on the structure and conformation of a highly constrained cyclic RGD peptide
Ku, Thomas W, Ali, Fadia E, Barton, Linda S, Bean, John W, Bondinell, William E, Burgess, Joelle L, Callahan, James F, Calvo, Raul R, Chen, Lichong
Published in Journal of the American Chemical Society (01.09.1993)
Published in Journal of the American Chemical Society (01.09.1993)
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Defining and Combating the Mechanisms of Triclosan Resistance in Clinical Isolates of Staphylococcus aureus
FAN, Frank, KANG YAN, SEEFELD, Mark A, NEWLANDER, Kenneth A, JAKAS, Dalia R, HEAD, Martha S, PAYNE, David J, WALLIS, Nicola G, REED, Shannon, MOORE, Terrance D, RITTENHOUSE, Stephen F, DEWOLF, Walter E, JIANZHONG HUANG, MCDEVITT, Damien, MILLER, William H
Published in Antimicrobial Agents and Chemotherapy (01.11.2002)
Published in Antimicrobial Agents and Chemotherapy (01.11.2002)
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The use of rabbit intestinal permeability as an in vitro assay in the search for orally active GPIIb/IIIa antagonists: In vitro models for selection of development candidates
SAMANEN, J. M, LEE, C.-P, NICHOLS, A. J, SMITH, P. L, BONDINELL, W. E, CALVO, R. R, JAKAS, D. R, NEWLANDER, K. A, PARKER, M, UZINSKAS, I, YELLIN, T. O
Published in Advanced drug delivery reviews (1997)
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Published in Advanced drug delivery reviews (1997)
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