ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin
Keskitalo, J E, Zolk, O, Fromm, M F, Kurkinen, K J, Neuvonen, P J, Niemi, M
Published in Clinical pharmacology and therapeutics (01.08.2009)
Published in Clinical pharmacology and therapeutics (01.08.2009)
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Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug-drug interactions
Tornio, A, Filppula, A M, Kailari, O, Neuvonen, M, Nyrönen, T H, Tapaninen, T, Neuvonen, P J, Niemi, M, Backman, J T
Published in Clinical pharmacology and therapeutics (01.10.2014)
Published in Clinical pharmacology and therapeutics (01.10.2014)
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Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans
Tarkiainen, E K, Holmberg, M T, Tornio, A, Neuvonen, M, Neuvonen, P J, Backman, J T, Niemi, M
Published in Clinical pharmacology and therapeutics (01.06.2015)
Published in Clinical pharmacology and therapeutics (01.06.2015)
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Carboxylesterase 1 polymorphism impairs oseltamivir bioactivation in humans
Tarkiainen, E K, Backman, J T, Neuvonen, M, Neuvonen, P J, Schwab, M, Niemi, M
Published in Clinical pharmacology and therapeutics (01.07.2012)
Published in Clinical pharmacology and therapeutics (01.07.2012)
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Grapefruit juice inhibits the metabolic activation of clopidogrel
Holmberg, M T, Tornio, A, Neuvonen, M, Neuvonen, P J, Backman, J T, Niemi, M
Published in Clinical pharmacology and therapeutics (01.03.2014)
Published in Clinical pharmacology and therapeutics (01.03.2014)
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UDP-glucuronosyltransferase (UGT) polymorphisms affect atorvastatin lactonization in vitro and in vivo
Riedmaier, S, Klein, K, Hofmann, U, Keskitalo, J E, Neuvonen, P J, Schwab, M, Niemi, M, Zanger, U M
Published in Clinical pharmacology and therapeutics (01.01.2010)
Published in Clinical pharmacology and therapeutics (01.01.2010)
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Mechanism-based inactivation of CYP2C8 by gemfibrozil occurs rapidly in humans
Honkalammi, J, Niemi, M, Neuvonen, P J, Backman, J T
Published in Clinical pharmacology and therapeutics (01.04.2011)
Published in Clinical pharmacology and therapeutics (01.04.2011)
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Gemfibrozil is a strong inactivator of CYP2C8 in very small multiple doses
Honkalammi, J, Niemi, M, Neuvonen, P J, Backman, J T
Published in Clinical pharmacology and therapeutics (01.05.2012)
Published in Clinical pharmacology and therapeutics (01.05.2012)
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The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo
Tornio, A, Niemi, M, Neuvonen, M, Laitila, J, Kalliokoski, A, Neuvonen, P J, Backman, J T
Published in Clinical pharmacology and therapeutics (01.09.2008)
Published in Clinical pharmacology and therapeutics (01.09.2008)
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Plasma concentrations of oral oxycodone are greatly increased in the elderly
Liukas, A, Kuusniemi, K, Aantaa, R, Virolainen, P, Neuvonen, M, Neuvonen, P J, Olkkola, K T
Published in Clinical pharmacology and therapeutics (01.10.2008)
Published in Clinical pharmacology and therapeutics (01.10.2008)
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Oxycodone clearance is markedly reduced with advancing age: a population pharmacokinetic study
Saari, T.I., Ihmsen, H., Neuvonen, P.J., Olkkola, K.T., Schwilden, H.
Published in British journal of anaesthesia : BJA (01.03.2012)
Published in British journal of anaesthesia : BJA (01.03.2012)
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