Proteomic Quantification of Human Blood–Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia Patients
Al-Majdoub, Zubida M, Al Feteisi, Hajar, Achour, Brahim, Warwood, Stacey, Neuhoff, Sibylle, Rostami-Hodjegan, Amin, Barber, Jill
Published in Molecular pharmaceutics (04.03.2019)
Published in Molecular pharmaceutics (04.03.2019)
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Journal Article
Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations
Taskar, Kunal S., Pilla Reddy, Venkatesh, Burt, Howard, Posada, Maria M., Varma, Manthena, Zheng, Ming, Ullah, Mohammed, Emami Riedmaier, Arian, Umehara, Ken‐ichi, Snoeys, Jan, Nakakariya, Masanori, Chu, Xiaoyan, Beneton, Maud, Chen, Yuan, Huth, Felix, Narayanan, Rangaraj, Mukherjee, Dwaipayan, Dixit, Vaishali, Sugiyama, Yuichi, Neuhoff, Sibylle
Published in Clinical pharmacology and therapeutics (01.05.2020)
Published in Clinical pharmacology and therapeutics (01.05.2020)
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Journal Article
Population-Based Mechanistic Prediction of Oral Drug Absorption
Jamei, Masoud, Turner, David, Yang, Jiansong, Neuhoff, Sibylle, Polak, Sebastian, Rostami-Hodjegan, Amin, Tucker, Geoffrey
Published in The AAPS journal (01.06.2009)
Published in The AAPS journal (01.06.2009)
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Journal Article
Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP2C8 and OATP1B Drug Substrates
Tan, Ming‐Liang, Zhao, Ping, Zhang, Lei, Ho, Yunn‐Fang, Varma, Manthena V.S., Neuhoff, Sibylle, Nolin, Thomas D., Galetin, Aleksandra, Huang, Shiew‐Mei
Published in Clinical pharmacology and therapeutics (01.03.2019)
Published in Clinical pharmacology and therapeutics (01.03.2019)
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Journal Article
Intestinal P-gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications
Zamek-Gliszczynski, Maciej J, Patel, Mitesh, Yang, Xinning, Lutz, Justin D, Chu, Xiaoyan, Brouwer, Kim L R, Lai, Yurong, Lee, Caroline A, Neuhoff, Sibylle, Paine, Mary F, Sugiyama, Yuichi, Taskar, Kunal S, Galetin, Aleksandra
Published in Clinical pharmacology and therapeutics (01.01.2021)
Published in Clinical pharmacology and therapeutics (01.01.2021)
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Journal Article
In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition
Murata, Yukiko, Neuhoff, Sibylle, Rostami-Hodjegan, Amin, Takita, Hiroyuki, Al-Majdoub, Zubida M., Ogungbenro, Kayode
Published in The AAPS journal (13.01.2022)
Published in The AAPS journal (13.01.2022)
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Journal Article
Guide to development of compound files for PBPK modeling in the Simcyp population‐based simulator
Ezuruike, Udoamaka, Zhang, Mian, Pansari, Amita, De Sousa Mendes, Mailys, Pan, Xian, Neuhoff, Sibylle, Gardner, Iain
Published in CPT: pharmacometrics and systems pharmacology (01.07.2022)
Published in CPT: pharmacometrics and systems pharmacology (01.07.2022)
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Journal Article
Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P‐glycoprotein–cytochrome P450 3A4 dual substrates
Pan, Xian, Yamazaki, Shinji, Neuhoff, Sibylle, Zhang, Mian, Pilla Reddy, Venkatesh
Published in CPT: pharmacometrics and systems pharmacology (01.12.2021)
Published in CPT: pharmacometrics and systems pharmacology (01.12.2021)
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Journal Article
More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter‐Mediated Clearances
Emami Riedmaier, Ariane, Burt, Howard, Abduljalil, Khaled, Neuhoff, Sibylle
Published in Journal of clinical pharmacology (01.07.2016)
Published in Journal of clinical pharmacology (01.07.2016)
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Journal Article
Prediction of CYP‐mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator
Kilford, Peter J., Chen, Kuan‐Fu, Crewe, Kim, Gardner, Iain, Hatley, Oliver, Ke, Alice Ban, Neuhoff, Sibylle, Zhang, Mian, Rowland Yeo, Karen
Published in CPT: pharmacometrics and systems pharmacology (01.07.2022)
Published in CPT: pharmacometrics and systems pharmacology (01.07.2022)
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Journal Article
Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data
Gaohua, Lu, Neuhoff, Sibylle, Johnson, Trevor N., Rostami-Hodjegan, Amin, Jamei, Masoud
Published in Drug metabolism and pharmacokinetics (01.06.2016)
Published in Drug metabolism and pharmacokinetics (01.06.2016)
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Journal Article
PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants
Emoto, Chie, Johnson, Trevor N., Neuhoff, Sibylle, Hahn, David, Vinks, Alexander A., Fukuda, Tsuyoshi
Published in CPT: pharmacometrics and systems pharmacology (01.07.2018)
Published in CPT: pharmacometrics and systems pharmacology (01.07.2018)
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Journal Article
Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21
Sychterz, Caroline, Gardner, Iain, Chiang, Manting, Rachumallu, Ramakrishna, Neuhoff, Sibylle, Perera, Vidya, Merali, Samira, Schmidt, Brian J, Gaohua, Lu
Published in Metabolites (20.10.2022)
Published in Metabolites (20.10.2022)
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Journal Article
Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD
Murphy, William A, Diehl, Anna Mae, Loop, Matthew Shane, Fu, Dong, Guy, Cynthia D, Abdelmalek, Manal F, Karachaliou, Georgia Sofia, Sjöstedt, Noora, Neuhoff, Sibylle, Honkakoski, Paavo, Brouwer, Kim L R
Published in Hepatology communications (01.03.2024)
Published in Hepatology communications (01.03.2024)
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Journal Article
Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions
Antonescu, Irina E, Karlgren, Maria, Pedersen, Maria L, Simoff, Ivailo, Bergström, Christel A S, Neuhoff, Sibylle, Artursson, Per, Steffansen, Bente, Nielsen, Carsten Uhd
Published in Pharmaceutics (24.04.2020)
Published in Pharmaceutics (24.04.2020)
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Journal Article