The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding
Liddle, John, Pearce, Andrew C., Arico-Muendel, Christopher, Belyanskaya, Svetlana, Brewster, Andrew, Brown, Murray, Chung, Chun-wa, Denis, Alexis, Dodic, Nerina, Dossang, Anthony, Eddershaw, Peter, Klimaszewska, Diana, Haq, Imran, Holmes, Duncan S., Jagger, Alistair, Jakhria, Toral, Jigorel, Emilie, Lind, Ken, Messer, Jeff, Neu, Margaret, Olszewski, Allison, Ronzoni, Riccardo, Rowedder, James, Rüdiger, Martin, Skinner, Steve, Smith, Kathrine J., Trottet, Lionel, Uings, Iain, Zhu, Zhengrong, Irving, James A., Lomas, David A.
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
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Journal Article
The development of highly potent and selective small molecule correctors of Z alpha 1-antitrypsin misfolding
Liddle, John, Pearce, Andrew C., Arico-Muendel, Christopher, Belyanskaya, Svetlana, Brewster, Andrew, Brown, Murray, Chung, Chun-wa, Denis, Alexis, Dodic, Nerina, Dossang, Anthony, Eddershaw, Peter, Klimaszewska, Diana, Haq, Imran, Holmes, Duncan S., Jagger, Alistair, Jakhria, Toral, Jigorel, Emilie, Lind, Ken, Messer, Jeff, Neu, Margaret, Olszewski, Allison, Ronzoni, Riccardo, Rowedder, James, Rudiger, Martin, Skinner, Steve, Smith, Kathrine J., Trottet, Lionel, Uings, Iain, Zhu, Zhengrong, Irving, James A., Lomas, David A.
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
Get full text
Journal Article
Development of a small molecule that corrects misfolding and increases secretion of Z α1‐antitrypsin
Lomas, David A, Irving, James A, Arico‐Muendel, Christopher, Belyanskaya, Svetlana, Brewster, Andrew, Brown, Murray, Chung, Chun‐wa, Dave, Hitesh, Denis, Alexis, Dodic, Nerina, Dossang, Anthony, Eddershaw, Peter, Klimaszewska, Diana, Haq, Imran, Holmes, Duncan S, Hutchinson, Jonathan P, Jagger, Alistair M, Jakhria, Toral, Jigorel, Emilie, Liddle, John, Lind, Ken, Marciniak, Stefan J, Messer, Jeff, Neu, Margaret, Olszewski, Allison, Ordonez, Adriana, Ronzoni, Riccardo, Rowedder, James, Rüdiger, Martin, Skinner, Steve, Smith, Kathrine J, Terry, Rebecca, Trottet, Lionel, Uings, Iain, Wilson, Steve, Zhu, Zhengrong, Pearce, Andrew C
Published in EMBO molecular medicine (05.03.2021)
Published in EMBO molecular medicine (05.03.2021)
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Journal Article
Development of a small molecule that corrects misfolding and increases secretion of Z α 1 -antitrypsin
Lomas, David A, Irving, James A, Arico-Muendel, Christopher, Belyanskaya, Svetlana, Brewster, Andrew, Brown, Murray, Chung, Chun-Wa, Dave, Hitesh, Denis, Alexis, Dodic, Nerina, Dossang, Anthony, Eddershaw, Peter, Klimaszewska, Diana, Haq, Imran, Holmes, Duncan S, Hutchinson, Jonathan P, Jagger, Alistair M, Jakhria, Toral, Jigorel, Emilie, Liddle, John, Lind, Ken, Marciniak, Stefan J, Messer, Jeff, Neu, Margaret, Olszewski, Allison, Ordonez, Adriana, Ronzoni, Riccardo, Rowedder, James, Rüdiger, Martin, Skinner, Steve, Smith, Kathrine J, Terry, Rebecca, Trottet, Lionel, Uings, Iain, Wilson, Steve, Zhu, Zhengrong, Pearce, Andrew C
Published in EMBO molecular medicine (05.03.2021)
Published in EMBO molecular medicine (05.03.2021)
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Journal Article
Exploring the SAR of the β‑Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite
Cunningham, Fraser, Esquivias, Jorge, Fernández-Menéndez, Raquel, Pérez, Arancha, Guardia, Ana, Escribano, Jaime, Rivero, Cristina, Vimal, Mythily, Cacho, Mónica, de Dios-Antón, Paco, Martínez-Martínez, María Santos, Jiménez, Elena, Huertas Valentín, Leticia, Rebollo-López, María José, López-Román, Eva María, Sousa-Morcuende, Verónica, Rullas, Joaquín, Neu, Margaret, Chung, Chun-wa, Bates, Robert H
Published in ACS infectious diseases (08.05.2020)
Published in ACS infectious diseases (08.05.2020)
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Journal Article
Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin
Lomas, David, Irving, James A, Arico-Muendel, Christopher, Belyanskaya, Svetlana, Brewster, Andy, Brown, Murray J B, Chun-Wa Chung, Dave, Hitesh, Denis, Alexis, Dodic, Nerina, Dossang, Anthony, Eddershaw, Peter, Klimaszewska, Diana, Haq, Imran, Holmes, Duncan, Hutchinson, Jon, Jagger, Alistair M, Toral Jakhria, Jigorel, Emilie, Liddle, John, Lind, Ken, Marciniak, Stefan John, Messer, Jeff, Neu, Margaret, Olszewski, Allison, Ordoñez, Adriana, Ronzoni, Riccardo, Rowedder, James, Martin, Rüdiger, Skinner, Steven, Smith, Kate, Terry, Rebecca, Trottet, Lionel, Uings, Iain, Wilson, Steve, Zhu, Zhengrong, Pearce, Andrew C
Published in bioRxiv (28.07.2020)
Published in bioRxiv (28.07.2020)
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