Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease
Greengard, Paul, He, Gen, Luo, Wenjie, Li, Peng, Remmers, Christine, Netzer, William J, Hendrick, Joseph, Bettayeb, Karima, Flajolet, Marc, Gorelick, Fred, Wennogle, Lawrence P
Published in Nature (London) (02.09.2010)
Published in Nature (London) (02.09.2010)
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Journal Article
Stretching the structural envelope of imatinib to reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP
Netzer, William J, Sinha, Anjana, Ghias, Mondana, Chang, Emily, Gindinova, Katherina, Mui, Emily, Seo, Ji-Seon, Sinha, Subhash C
Published in Frontiers in chemistry (08.10.2024)
Published in Frontiers in chemistry (08.10.2024)
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Journal Article
Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model
Netzer, William J, Powell, Craig, Nong, Yi, Blundell, Jacqueline, Wong, Lili, Duff, Karen, Flajolet, Marc, Greengard, Paul
Published in PloS one (03.06.2010)
Published in PloS one (03.06.2010)
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Journal Article
Chaperones Increase Association of tau Protein with Microtubules
Dou, Fei, Netzer, William J., Tanemura, Kentaro, Li, Feng, Hartl, F. Ulrich, Takashima, Akihiko, Gouras, Gunnar K., Greengard, Paul, Xu, Huaxi
Published in Proceedings of the National Academy of Sciences - PNAS (21.01.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (21.01.2003)
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Journal Article
Inhibition of Amyloid-β Aggregation and Caspase-3 Activation by the Ginkgo biloba Extract EGb761
Luo, Yuan, Smith, Julie V., Paramasivam, Vijaykumar, Burdick, Adam, Curry, Kenneth J., Buford, Justin P., Khan, Ikhlas, Netzer, William J., Xu, Huaxi, Butko, Peter
Published in Proceedings of the National Academy of Sciences - PNAS (17.09.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (17.09.2002)
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Journal Article
Overactivation of glycogen synthase kinase‐3 by inhibition of phosphoinositol‐3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory
Liu, Shi Jie, Zhang, Ai Hong, Li, Hong Lian, Wang, Qun, Deng, Heng Mei, Netzer, William J., Xu, Huaxi, Wang, Jian Zhi
Published in Journal of neurochemistry (01.12.2003)
Published in Journal of neurochemistry (01.12.2003)
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Journal Article
Dynamin 1 regulates amyloid generation through modulation of BACE-1
Zhu, Li, Su, Meng, Lucast, Louise, Liu, Lijuan, Netzer, William J, Gandy, Samuel E, Cai, Dongming
Published in PloS one (14.09.2012)
Published in PloS one (14.09.2012)
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Journal Article
Gleevec Inhibits β-Amyloid Production but Not Notch Cleavage
Netzer, William J., Dou, Fei, Cai, Dongming, Veach, Darren, Jean, Stephanie, Li, Yueming, Bornmann, William G., Clarkson, Bayard, Xu, Huaxi, Greengard, Paul
Published in Proceedings of the National Academy of Sciences - PNAS (14.10.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (14.10.2003)
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Journal Article
Phospholipase D1 Corrects Impaired βAPP Trafficking and Neurite Outgrowth in Familial Alzheimer's Disease-Linked Presenilin-1 Mutant Neurons
Cai, Dongming, Zhong, Minghao, Wang, Runsheng, Netzer, William J., Shields, Dennis, Zheng, Hui, Sisodia, Sangram S., Foster, David A., Gorelick, Fred S., Xu, Huaxi, Greengard, Paul
Published in Proceedings of the National Academy of Sciences - PNAS (07.02.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (07.02.2006)
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Journal Article
Presenilin-1 Uses Phospholipase D1 as a Negative Regulator of β-Amyloid Formation
Cai, Dongming, Netzer, William J., Zhong, Minghao, Lin, Yixin, Du, Guangwei, Frohman, Michael, Foster, David A., Sisodia, Sangram S., Xu, Huaxi, Gorelick, Fred S., Greengard, Paul
Published in Proceedings of the National Academy of Sciences - PNAS (07.02.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (07.02.2006)
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Journal Article
Development of Gleevec Analogues for Reducing Production of β‑Amyloid Peptides through Shifting β‑Cleavage of Amyloid Precursor Proteins
Sun, Weilin, Netzer, William J, Sinha, Anjana, Gindinova, Katherina, Chang, Emily, Sinha, Subhash C
Published in Journal of medicinal chemistry (28.03.2019)
Published in Journal of medicinal chemistry (28.03.2019)
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Journal Article
δ-COP modulates Aβ peptide formation via retrograde trafficking of APP
Bettayeb, Karima, Chang, Jerry C., Luo, Wenjie, Aryal, Suvekshya, Varotsis, Dante, Randolph, Lisa, Netzer, William J., Greengard, Paul, Flajolet, Marc
Published in Proceedings of the National Academy of Sciences - PNAS (10.05.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (10.05.2016)
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Journal Article
Development of Kinase Inactive PD173955 Analogues for Reducing Production of Aβ Peptides
Sinha, Anjana, Gindinova, Katherina, Mui, Emily, Netzer, William J, Sinha, Subhash C
Published in ACS medicinal chemistry letters (10.10.2019)
Published in ACS medicinal chemistry letters (10.10.2019)
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Journal Article
Beta-amyloid modulation of synaptic transmission and plasticity
Venkitaramani, Deepa V, Chin, Jeannie, Netzer, William J, Gouras, Gunnar K, Lesne, Sylvain, Malinow, Roberto, Lombroso, Paul J
Published in The Journal of neuroscience (31.10.2007)
Published in The Journal of neuroscience (31.10.2007)
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Journal Article
Does insulin dysfunction play a role in Alzheimer's disease?
Gasparini, Laura, Netzer, William J., Greengard, Paul, Xu, Huaxi
Published in Trends in Pharmacological Sciences (01.06.2002)
Published in Trends in Pharmacological Sciences (01.06.2002)
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Book Review
Journal Article
A Functional Mouse Retroposed Gene Rps23r1 Reduces Alzheimer's β-Amyloid Levels and Tau Phosphorylation
Zhang, Yun-wu, Liu, Shijie, Zhang, Xue, Li, Wu-Bo, Chen, Yaomin, Huang, Xiumei, Sun, Liangwu, Luo, Wenjie, Netzer, William J., Threadgill, Richard, Wiegand, Gordon, Wang, Ruishan, Cohen, Stanley N., Greengard, Paul, Liao, Francesca-Fang, Li, Limin, Xu, Huaxi
Published in Neuron (Cambridge, Mass.) (12.11.2009)
Published in Neuron (Cambridge, Mass.) (12.11.2009)
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Journal Article
[delta]-COP modulates A[Beta] peptide formation via retrograde trafficking of APP
Bettayeb, Karima, Chang, Jerry C, Luo, Wenjie, Aryal, Suvekshya, Varotsis, Dante, Randolph, Lisa, Netzer, William J, Greengard, Paul, Flajolet, Marc
Published in Proceedings of the National Academy of Sciences - PNAS (10.05.2016)
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Published in Proceedings of the National Academy of Sciences - PNAS (10.05.2016)
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