Unearthing the Janus-face cholesterogenesis pathways in cancer
Madan, Babita, Virshup, David M., Nes, W. David, Leaver, David J.
Published in Biochemical pharmacology (01.02.2022)
Published in Biochemical pharmacology (01.02.2022)
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Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells
Santori, Fabio R., Huang, Pengxiang, van de Pavert, Serge A., Douglass, Eugene F., Leaver, David J., Haubrich, Brad A., Keber, Rok, Lorbek, Gregor, Konijn, Tanja, Rosales, Brittany N., Rozman, Damjana, Horvat, Simon, Rahier, Alain, Mebius, Reina E., Rastinejad, Fraydoon, Nes, W. David, Littman, Dan R.
Published in Cell metabolism (03.02.2015)
Published in Cell metabolism (03.02.2015)
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A nematode sterol C4α-methyltransferase catalyzes a new methylation reaction responsible for sterol diversity[S]
Zhou, Wenxu, Fisher, Paxtyn M., Vanderloop, Boden H., Shen, Yun, Shi, Huazhong, Maldonado, Adrian J., Leaver, David J., Nes, W. David
Published in Journal of lipid research (01.02.2020)
Published in Journal of lipid research (01.02.2020)
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Journal Article
Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri
Zhou, Wenxu, Debnath, Anjan, Jennings, Gareth, Hahn, Hye Jee, Vanderloop, Boden H, Chaudhuri, Minu, Nes, W David, Podust, Larissa M
Published in PLoS pathogens (01.09.2018)
Published in PLoS pathogens (01.09.2018)
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Journal Article
Steroidal Antimetabolites Protect Mice against Trypanosoma brucei
Chaudhuri, Minu, Singha, Ujjal K, Vanderloop, Boden H, Tripathi, Anuj, Nes, W David
Published in Molecules (Basel, Switzerland) (25.06.2022)
Published in Molecules (Basel, Switzerland) (25.06.2022)
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Journal Article
Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design
Kidane, Medhanie E., Vanderloop, Boden H., Zhou, Wenxu, Thomas, Crista D., Ramos, Emilio, Singha, Ujjal, Chaudhuri, Minu, Nes, W. David
Published in Journal of lipid research (01.12.2017)
Published in Journal of lipid research (01.12.2017)
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Journal Article
CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)
Debnath, Anjan, Calvet, Claudia M, Jennings, Gareth, Zhou, Wenxu, Aksenov, Alexander, Luth, Madeline R, Abagyan, Ruben, Nes, W David, McKerrow, James H, Podust, Larissa M
Published in PLoS neglected tropical diseases (01.12.2017)
Published in PLoS neglected tropical diseases (01.12.2017)
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Journal Article
Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51
Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Fisher, Paxtyn M., Child, Stella A., Nes, W. David, Guengerich, F. Peter, Waterman, Michael R., Lepesheva, Galina I.
Published in The Journal of biological chemistry (14.12.2018)
Published in The Journal of biological chemistry (14.12.2018)
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Journal Article
Druggable Sterol Metabolizing Enzymes in Infectious Diseases: Cell Targets to Therapeutic Leads
Nes, W David, Chaudhuri, Minu, Leaver, David J
Published in Biomolecules (Basel, Switzerland) (20.02.2024)
Published in Biomolecules (Basel, Switzerland) (20.02.2024)
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Journal Article
Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Δ7-24, 25-dihydrolanosterol
Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Liu, Jialin, Waterman, Michael R., Nes, W. David, Lepesheva, Galina I.
Published in Journal of lipid research (01.02.2012)
Published in Journal of lipid research (01.02.2012)
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Journal Article
24-Methylenecyclopropane steroidal inhibitors: A Trojan horse in ergosterol biosynthesis that prevents growth of Trypanosoma brucei
Miller, Matthew B., Patkar, Presheet, Singha, Ujjal K., Chaudhuri, Minu, David Nes, W.
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.03.2017)
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.03.2017)
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Journal Article
Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications
Zhou, Wenxu, Ramos, Emilio, Zhu, Xunlu, Fisher, Paxtyn M., Kidane, Medhanie E., Vanderloop, Boden H., Thomas, Crista D., Yan, Juqiang, Singha, Ujjal, Chaudhuri, Minu, Nagel, Michael T., Nes, W.David
Published in Journal of lipid research (01.05.2019)
Published in Journal of lipid research (01.05.2019)
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Journal Article
Mechanism of Binding of Prothioconazole to Mycosphaerella graminicola CYP51 Differs from That of Other Azole Antifungals
Parker, Josie E, Warrilow, Andrew G.S, Cools, Hans J, Martel, Claire M, Nes, W. David, Fraaije, Bart A, Lucas, John A, Kelly, Diane E, Kelly, Steven L
Published in Applied and Environmental Microbiology (01.02.2011)
Published in Applied and Environmental Microbiology (01.02.2011)
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Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14-α Demethylase (CYP51) Isoenzymes A and B
WARRILOW, Andrew G. S, MELO, Nadja, MARTEL, Claire M, PARKER, Josie E, NES, W. David, KELLY, Steven L, KELLY, Diane E
Published in Antimicrobial Agents and Chemotherapy (01.10.2010)
Published in Antimicrobial Agents and Chemotherapy (01.10.2010)
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Journal Article
Azole Binding Properties of Candida albicans Sterol 14-α Demethylase (CaCYP51)
WARRILOW, Andrew G. S, MARTEL, Claire M, PARKER, Josie E, MELO, Nadja, LAMB, David C, NES, W. David, KELLY, Diane E, KELLY, Steven L
Published in Antimicrobial Agents and Chemotherapy (01.10.2010)
Published in Antimicrobial Agents and Chemotherapy (01.10.2010)
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Journal Article
Characterization, mutagenesis and mechanistic analysis of an ancient algal sterol C24-methyltransferase: Implications for understanding sterol evolution in the green lineage
Haubrich, Brad A., Collins, Emily K., Howard, Alicia L., Wang, Qian, Snell, William J., Miller, Matthew B., Thomas, Crista D., Pleasant, Stephanie K., Nes, W. David
Published in Phytochemistry (Oxford) (01.05.2015)
Published in Phytochemistry (Oxford) (01.05.2015)
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Journal Article
Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms
Nes, Craigen R, Singha, Ujjal K, Liu, Jialin, Ganapathy, Kulothungan, Villalta, Fernando, Waterman, Michael R, Lepesheva, Galina I, Chaudhuri, Minu, Nes, W David
Published in Biochemical journal (01.04.2012)
Published in Biochemical journal (01.04.2012)
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Journal Article
Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth[S]
Haubrich, Brad A., Singha, Ujjal K., Miller, Matthew B., Nes, Craigen R., Anyatonwu, Hosanna, Lecordier, Laurence, Patkar, Presheet, Leaver, David J., Villalta, Fernando, Vanhollebeke, Benoit, Chaudhuri, Minu, Nes, W. David
Published in Journal of lipid research (01.02.2015)
Published in Journal of lipid research (01.02.2015)
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