Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy
Patin, Emmanuel C., Nenclares, Pablo, Chan Wah Hak, Charleen, Dillon, Magnus T., Patrikeev, Anton, McLaughlin, Martin, Grove, Lorna, Foo, Shane, Soliman, Heba, Barata, Joao P., Marsden, Joanna, Baldock, Holly, Gkantalis, Jim, Roulstone, Victoria, Kyula, Joan, Burley, Amy, Hubbard, Lisa, Pedersen, Malin, Smith, Simon A., Clancy-Thompson, Eleanor, Melcher, Alan A., Ono, Masahiro, Rullan, Antonio, Harrington, Kevin J.
Published in Nature communications (13.08.2024)
Published in Nature communications (13.08.2024)
Get full text
Journal Article
Harnessing radiotherapy-induced NK-cell activity by combining DNA damage–response inhibition and immune checkpoint blockade
Patin, Emmanuel C, Dillon, Magnus T, Nenclares, Pablo, Grove, Lorna, Soliman, Heba, Leslie, Isla, Northcote, Davina, Bozhanova, Galabina, Crespo-Rodriguez, Eva, Baldock, Holly, Whittock, Harriet, Baker, Gabriella, Kyula, Joan, Guevara, Jeane, Melcher, Alan A, Harper, James, Ghadially, Hormas, Smith, Simon, Pedersen, Malin, McLaughlin, Martin, Harrington, Kevin J
Published in Journal for immunotherapy of cancer (01.03.2022)
Published in Journal for immunotherapy of cancer (01.03.2022)
Get full text
Journal Article
T-cell receptor determinants of response to chemoradiation in locally-advanced HPV16-driven malignancies
Nenclares, Pablo, Larkeryd, Adrian, Manodoro, Floriana, Lee, Jen Y, Lalondrelle, Susan, Gilbert, Duncan C, Punta, Marco, O'Leary, Ben, Rullan, Antonio, Sadanandam, Anguraj, Chain, Benny, Melcher, Alan, Harrington, Kevin J, Bhide, Shreerang A
Published in Frontiers in oncology (03.01.2024)
Published in Frontiers in oncology (03.01.2024)
Get full text
Journal Article
On-treatment immune prognostic score for patients with relapsed and/or metastatic head and neck squamous cell carcinoma treated with immunotherapy
Nenclares, Pablo, Gunn, Lucinda, Soliman, Heba, Bover, Mateo, Trinh, Amy, Leslie, Isla, Wong, Kee Howe, Melcher, Alan, Newbold, Kate, Nutting, Chris M, ap Dafydd, Derfel, Bhide, Shreerang A, Harrington, Kevin
Published in Journal for immunotherapy of cancer (01.06.2021)
Published in Journal for immunotherapy of cancer (01.06.2021)
Get full text
Journal Article
Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell receptor signalling
Armstrong, Edward, Chiu, Matthew K L, Foo, Shane, Appleton, Lizzie, Nenclares, Pablo, Patrikeev, Anton, Mohan, Nitya, Mclaughlin, Martin, Bozhanova, Galabina, Hoebart, Julia, Roulstone, Victoria, Patin, Emmanuel, Pedersen, Malin, Kyula, Joan, Ono, Masahiro, Errington-Mais, Fiona, Bell, John, Harrington, Kevin J, Melcher, Alan, Jennings, Victoria
Published in Journal for immunotherapy of cancer (25.07.2024)
Published in Journal for immunotherapy of cancer (25.07.2024)
Get full text
Journal Article
Cancer cell – Fibroblast crosstalk via HB-EGF, EGFR, and MAPK signaling promotes the expression of macrophage chemo-attractants in squamous cell carcinoma
Giangreco, Giovanni, Rullan, Antonio, Naito, Yutaka, Biswas, Dhruva, Liu, Yun-Hsin, Hooper, Steven, Nenclares, Pablo, Bhide, Shreerang, Chon U Cheang, Maggie, Chakravarty, Probir, Hirata, Eishu, Swanton, Charles, Melcher, Alan, Harrington, Kevin, Sahai, Erik
Published in iScience (20.09.2024)
Published in iScience (20.09.2024)
Get full text
Journal Article
507 A phase 1 clinical trial of RP2, an enhanced potency oncolytic HSV expressing an anti-CTLA-4 antibody, as a single agent and combined with nivolumab in patients with advanced solid tumors
Middleton, Mark, Sacco, Joseph, Harrington, Kevin, Olsson-Brown, Anna, Chan, Tze, Nenclares, Pablo, Leslie, Isla, Aroldi, Francesca, Bommareddy, Praveen, Saleem, Imran, Castro, Henry, Pirzkall, Andrea, Coffin, Robert
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
Get full text
Journal Article
Taste dysfunction following radiotherapy to the head and neck: A systematic review
Gunn, Lucinda, Gilbert, James, Nenclares, Pablo, Soliman, Heba, Newbold, Kate, Bhide, Shree, Wong, Kee Howe, Harrington, Kevin, Nutting, Chris
Published in Radiotherapy and oncology (01.04.2021)
Published in Radiotherapy and oncology (01.04.2021)
Get full text
Journal Article
Impact of antibiotic use during curative treatment of locally advanced head and neck cancers with chemotherapy and radiotherapy
Nenclares, Pablo, Bhide, Sheerang A., Sandoval-Insausti, Helena, Pialat, Pierre, Gunn, Lucinda, Melcher, Alan, Newbold, Kate, Nutting, Christopher M., Harrington, Kevin J.
Published in European journal of cancer (1990) (01.05.2020)
Published in European journal of cancer (1990) (01.05.2020)
Get full text
Journal Article
Management of Head and Neck Mucosal Melanoma
Nenclares, Pablo, Harrington, Kevin J
Published in Oral and maxillofacial surgery clinics of North America (01.05.2022)
Published in Oral and maxillofacial surgery clinics of North America (01.05.2022)
Get more information
Journal Article
Head and neck mucosal melanoma: The United Kingdom national guidelines
Nenclares, Pablo, Ap Dafydd, Derfel, Bagwan, Izhar, Begg, Donna, Kerawala, Cyrus, King, Emma, Lingley, Ken, Paleri, Vinidh, Paterson, Gillian, Payne, Miranda, Silva, Priyamal, Steven, Neil, Turnbull, Nancy, Yip, Kent, Harrington, Kevin J.
Published in European journal of cancer (1990) (01.10.2020)
Published in European journal of cancer (1990) (01.10.2020)
Get full text
Journal Article
Preliminary safety and efficacy results from an open-label, multicenter, phase 1 study of RP2 as a single agent and in combination with nivolumab in a cohort of patients with uveal melanoma
Sacco, Joseph J., Harrington, Kevin Joseph, Olsson-Brown, Anna, Chan, Tze Y, Nenclares, Pablo, Leslie, Isla, Bommareddy, Praveen, Xie, Ben, Wolff, Johannes, Middleton, Mark R.
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
Get full text
Journal Article
Defining the true impact of coronavirus disease 2019 in the at-risk population of patients with cancer
Angelis, Vasileios, Tippu, Zayd, Joshi, Kroopa, Reis, Sara, Gronthoud, Firza, Fribbens, Charlotte, Okines, Alicia, Stanway, Susannah, Cottier, Emma, McGrath, Sophie, Watkins, David, Noble, Jillian, Bhosle, Jaishree, Gerlinger, Marco, Hamid, Intan, Soliman, Heba, Nenclares, Pablo, Jones, Robin, Harrington, Kevin, Gennatas, Spyridon
Published in European journal of cancer (1990) (01.09.2020)
Published in European journal of cancer (1990) (01.09.2020)
Get full text
Journal Article
Safety, efficacy, and biomarker results from an open-label, multicenter, phase 1 study of RP2 alone or combined with nivolumab in a cohort of patients with uveal melanoma
Sacco, Joseph J, Harrington, Kevin Joseph, Olsson-Brown, Anna, Chan, Tze Y, Nenclares, Pablo, Leslie, Isla, Bommareddy, Praveen, Kalbasi, Alireza, Xie, Ben, Mishal, Moran, Cohan, David Michael, Skolariki, Aglaia, Middleton, Mark R.
Published in Journal of clinical oncology (01.06.2024)
Published in Journal of clinical oncology (01.06.2024)
Get full text
Journal Article
FUME-TCRseq enables sensitive and accurate sequencing of the T-cell receptor from limited input of degraded RNA
Baker, Ann-Marie, Nageswaran, Gayathri, Nenclares, Pablo, Ronel, Tahel, Smith, Kane, Kimberley, Christopher, Laclé, Miangela M, Bhide, Shreerang, Harrington, Kevin J, Melcher, Alan, Rodriguez-Justo, Manuel, Chain, Benny, Graham, Trevor A
Published in Cancer research (Chicago, Ill.) (15.05.2024)
Published in Cancer research (Chicago, Ill.) (15.05.2024)
Get full text
Journal Article
Overexpression of PIK3CA in head and neck squamous cell carcinoma is associated with poor outcome and activation of the YAP pathway
García-Escudero, Ramón, Segrelles, Carmen, Dueñas, Marta, Pombo, María, Ballestín, Claudio, Alonso-Riaño, Marina, Nenclares, Pablo, Álvarez-Rodríguez, Roberto, Sánchez-Aniceto, Gregorio, Ruíz-Alonso, Ana, López-Cedrún, José Luis, Paramio, Jesús M., Lorz, Corina
Published in Oral oncology (01.04.2018)
Published in Oral oncology (01.04.2018)
Get full text
Journal Article
A phase 1 trial of RP2, a first-in-class, enhanced potency oncolytic HSV expressing an anti-CTLA-4 antibody as a single agent and combined with nivolumab in patients with advanced solid tumors
Harrington, Kevin Joseph, Sacco, Joseph J., Olsson-Brown, Anna Claire, Chan, Tze Y, Nenclares, Pablo, Leslie, Isla, Saleem, Imran, Bommareddy, Praveen, Ahlers, Christoph Matthias, Coffin, Robert S., Middleton, Mark R.
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
Get full text
Journal Article
What is the role of the surgeon in the management of head and neck mucosal melanoma in the immunotherapy era?
Edmond, Mark, Nenclares, Pablo, Harrington, Kevin, Ap Dafydd, Derfel, Bagwan, Izhar, Begg, Donna, Lingley, Ken, Patterson, Gillian, Payne, Miranda, Steven, Neil, Turnbull, Nancy, Yip, Kent, Silva, Priyamal, Kerawala, Cyrus, Paleri, Vinidh, King, Emma
Published in Head & neck (01.11.2021)
Published in Head & neck (01.11.2021)
Get full text
Journal Article