Search Results - "Neil H. Squires" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors

Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors

by LANSDON, Eric B, QI LIU, KIRSCHBERG, Thorsten A, LEAVITT, Stephanie A, BALAKRISHNAN, Mini, PERRY, Jason K, LANCASTER-MOYER, Candra, KUTTY, Nilima, XIAOHONG LIU, SQUIRES, Neil H, WATKINS, William J
Published in Antimicrobial Agents and Chemotherapy (01.06.2011)

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Journal Article

RNase H Active Site Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Design, Biochemical Activity, and Structural Information

RNase H Active Site Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Design, Biochemical Activity, and Structural Information

by Kirschberg, Thorsten A, Balakrishnan, Mini, Squires, Neil H, Barnes, Tiffany, Brendza, Katherine M, Chen, Xiaowu, Eisenberg, Eugene J, Jin, Weili, Kutty, Nilima, Leavitt, Stephanie, Liclican, Albert, Liu, Qi, Liu, Xiaohong, Mak, John, Perry, Jason K, Wang, Michael, Watkins, William J, Lansdon, Eric B
Published in Journal of medicinal chemistry (08.10.2009)

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Discovery of a 2′-fluoro-2′-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties

Discovery of a 2′-fluoro-2′-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties

by Kirschberg, Thorsten A., Metobo, Sammy, Clarke, Michael O., Aktoudianakis, Vangelis, Babusis, Darius, Barauskas, Ona, Birkus, Gabriel, Butler, Thomas, Byun, Daniel, Chin, Gregory, Doerffler, Edward, Edwards, Thomas E., Fenaux, Martijn, Lee, Rick, Lew, Willard, Mish, Michael R., Murakami, Eisuke, Park, Yeojin, Squires, Neil H., Tirunagari, Neeraj, Wang, Ting, Whitcomb, Mark, Xu, Jie, Yang, Huiling, Ye, Hong, Zhang, Lijun, Appleby, Todd C., Feng, Joy Y., Ray, Adrian S., Cho, Aesop, Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (15.04.2017)

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Synthesis and characterization of 1′-C-cyano-2′-fluoro-2′-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors

Synthesis and characterization of 1′-C-cyano-2′-fluoro-2′-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors

by Kirschberg, Thorsten A., Mish, Michael R., Zhang, Lijun, Squires, Neil H., Wang, Ke-Yu, Cho, Aesop, Feng, Joy Y., Fenaux, Martijn, Babusis, Darius, Park, Yeojin, Ray, Adrian S., Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (01.03.2015)

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Journal Article

Synthesis of 1′-C-Cyano Pyrimidine Nucleosides and Characterization as HCV Polymerase Inhibitors

Synthesis of 1′-C-Cyano Pyrimidine Nucleosides and Characterization as HCV Polymerase Inhibitors

by Kirschberg, Thorsten A., Mish, Michael, Squires, Neil H., Zonte, Sebastian, Aktoudianakis, Evangelos, Metobo, Sammy, Butler, Thomas, Ju, Xie, Cho, Aesop, Ray, Adrian S., Kim, Choung U.
Published in Nucleosides, nucleotides & nucleic acids (02.11.2015)

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Journal Article

Novel, sulfonamide linked inhibitors of the hepatitis C virus NS3 protease

Novel, sulfonamide linked inhibitors of the hepatitis C virus NS3 protease

by Kirschberg, Thorsten A., Squires, Neil H., Yang, Huiling, Corsa, Amoreena C., Tian, Yang, Tirunagari, Neeraj, Sheng, X. Christopher, Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (01.02.2014)

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Journal Article

Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase—Structure–activity relationships and crystallographic analysis

Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase—Structure–activity relationships and crystallographic analysis

by Kirschberg, Thorsten A., Balakrishnan, Mini, Huang, Wei, Hluhanich, Rebecca, Kutty, Nilima, Liclican, Albert C., McColl, Damian J., Squires, Neil H., Lansdon, Eric B.
Published in Bioorganic & medicinal chemistry (01.02.2008)

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Journal Article

PRODRUGS OF 4'-C-SUBSTITUTED-2-HALO-2'-DEOXYADENOSINE NUCLEOSIDES AND METHODS OF MAKING AND USING THE SAME

PRODRUGS OF 4'-C-SUBSTITUTED-2-HALO-2'-DEOXYADENOSINE NUCLEOSIDES AND METHODS OF MAKING AND USING THE SAME

by CHUN BYOUNG-KWON, DEVAN NADUTHAMBI, PETR JANSA, MACKMAN RICHARD L, DANIEL H BYUN, NEIL H SQUIRES, MICHAEL O CLARKE
Year of Publication 10.05.2024

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Patent

PRODRUGS OF 4'-C-SUBSTITUTED-2-HALO-2'-DEOXYADENOSINE NUCLEOSIDES AND METHODS OF MAKING AND USING THE SAME

PRODRUGS OF 4'-C-SUBSTITUTED-2-HALO-2'-DEOXYADENOSINE NUCLEOSIDES AND METHODS OF MAKING AND USING THE SAME

by CHUN BYOUNG-KWON, DEVAN NADUTHAMBI, PETR JANSA, MACKMAN RICHARD L, DANIEL H BYUN, NEIL H SQUIRES, MICHAEL O CLARKE
Year of Publication 10.05.2024

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PD-1/PD-L1 INHIBITORS

PD-1/PD-L1 INHIBITORS

by YANG KIN SHING, WATKINS WILLIAM J, XU JIE, CHO AESOP, MICHAEL GRAUPE, EVANGELOS AKTOUDIANAKIS, DEVAN NADUTHAMBI, JUAN A GUERRERO, JONATHAN WILLIAM MEDLEY, LATESHKUMAR THAKORLAL LAD, PRASENJIT KUMAR MUKHERJEE, BARTON W PHILLIPS, TODD APPLEBY, GREGORY NOTTE, ERIC Q PARKHILL, SCOTT PRESTON SIMONOVICH, PAULO A MACHICAO TELLO, CHANDRASEKAR VENKATARAMANI, SAMUEL E METOBO, NEIL H SQUIRES, DU ZHIMIN, CHRISTOPHER ALLEN ZIEBENHAUS, SALMAN Y JABRI, WANG PEIYUAN
Year of Publication 23.01.2024

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SUBSTITUTED PYRROLIZINE COMPOUND AND USE THEREOF

SUBSTITUTED PYRROLIZINE COMPOUND AND USE THEREOF

by WATKINS WILLIAM J, SOPHIA L SHEVICK, THORSTEN A KIRSCHBERG, SCOTT E LAZERWITH, JONATHAN WILLIAM MEDLEY, KOBAYASHI TETSUYA, RICK ANDREW LEE, PHILIP ANTHONY MORGANELLI, JOSHUA A KAPLAN, MICHAEL L MITCHELL, NEIL H SQUIRES, DU JINFA, HYUNG-JUNG PYUN
Year of Publication 21.01.2021

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MCL-1 INHIBITORS

MCL-1 INHIBITORS

by WATKINS WILLIAM J, HWANG TAE H, DEVAN NADUTHAMBI, DAVID W LIN, SCOTT E LAZERWITH, JUAN A GUERRERO, CHU HANG, KOBAYASHI TETSUYA, ANNA E HURTLEY, LI XIAOFEN, DARRYL KATO, YANG HONG, CHANDRASEKAR VENKATARAMANI, JONATHAN W MEDLEY, JIANG LAN, MICHAEL L MITCHELL, ZACHARY NEWBY, NEIL H SQUIRES, JOHN E KNOX, VICKIE H TSUI
Year of Publication 01.07.2021

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Patent

4,6-DIAMINO QUINAZOLINES AS COT MODULATOR AND ITS USE METHOD

4,6-DIAMINO QUINAZOLINES AS COT MODULATOR AND ITS USE METHOD

by KIM MUSONG, WATKINS WILLIAM J, ROLAND D SAITO, JOHN O LINK, GARY PHILLIPS, JAMES G TAYLOR, THORSTEN A KIRSCHBERG, GAYATRI BALAN, NEIL H SQUIRES, NATHAN E WRIGHT, CHOU CHIEN-HUNG
Year of Publication 14.05.2020

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Cot MODULATOR AND APPLICATION METHOD THEREOF

Cot MODULATOR AND APPLICATION METHOD THEREOF

by KIM MUSONG, WATKINS WILLIAM J, GARY PHILLIPS, JAMES G TAYLOR, CHRISTOPHER T CLARK, THORSTEN A KIRSCHBERG, GAYATRI BALAN, CHOU CHIEN-HUNG, KIRK L STEVENS, JEROMY J COTTELL, SCOTT D SCHROEDER, JOHN O LINK, ELIZABETH M BACON, NEIL H SQUIRES, NATHAN E WRIGHT, SHEILA M ZIPFEL
Year of Publication 18.03.2021

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Cot MODULATOR AND APPLICATION METHOD THEREFOR

Cot MODULATOR AND APPLICATION METHOD THEREFOR

by KIM MUSONG, WATKINS WILLIAM J, GARY PHILLIPS, JAMES G TAYLOR, CHRISTOPHER T CLARK, THORSTEN A KIRSCHBERG, GAYATRI BALAN, CHOU CHIEN-HUNG, KIRK L STEVENS, JEROMY J COTTELL, SCOTT D SCHROEDER, JOHN O LINK, ELIZABETH M BACON, NEIL H SQUIRES, NATHAN E WRIGHT, SHEILA M ZIPFEL
Year of Publication 17.10.2019

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Cot MODULATOR AND APPLICATION METHOD THEREOF

Cot MODULATOR AND APPLICATION METHOD THEREOF

by KIM MUSONG, WATKINS WILLIAM J, GARY PHILLIPS, JAMES G TAYLOR, CHRISTOPHER T CLARK, THORSTEN A KIRSCHBERG, GAYATRI BALAN, CHOU CHIEN-HUNG, KIRK L STEVENS, JEROMY J COTTELL, SCOTT D SCHROEDER, JOHN O LINK, ELIZABETH M BACON, NEIL H SQUIRES, NATHAN E WRIGHT, SHEILA M ZIPFEL
Year of Publication 06.12.2018

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Patent

Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use

Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use

by Naduthambi, Devan, Byun, Daniel H, Clarke, Michael O, Squires, Neil H, Jansa, Petr, Chun, Byoung-Kwon
Year of Publication 08.10.2024

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Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use

Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use

by NADUTHAMBI, Devan, BYUN, Daniel H, JANSA, Petr, CHUN, Byoung-Kwon, CLARKE, Michael O, SQUIRES, Neil H
Year of Publication 03.10.2024

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Patent

4'-THIONUCLEOSIDE ANALOGUES AND THEIR PHARMACEUTICAL USE

4'-THIONUCLEOSIDE ANALOGUES AND THEIR PHARMACEUTICAL USE

by Naduthambi, Devan, Mackman, Richard L, Clarke, Michael O, Goyal, Bindu, Squires, Neil H
Year of Publication 11.07.2024

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Patent

4'-THIONUCLEOSIDE ANALOGUES AND THEIR PHARMACEUTICAL USE

4'-THIONUCLEOSIDE ANALOGUES AND THEIR PHARMACEUTICAL USE

by GOYAL, Bindu, NADUTHAMBI, Devan, MACKMAN, Richard L, CLARKE, Michael O, SQUIRES, Neil H
Year of Publication 11.04.2024

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