ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation
Schumacher, Neele, Rose-John, Stefan, Schmidt-Arras, Dirk
Published in International journal of molecular sciences (20.07.2020)
Published in International journal of molecular sciences (20.07.2020)
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Journal Article
ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling
Schmidt, Stefanie, Schumacher, Neele, Schwarz, Jeanette, Tangermann, Simone, Kenner, Lukas, Schlederer, Michaela, Sibilia, Maria, Linder, Markus, Altendorf-Hofmann, Annelore, Knösel, Thomas, Gruber, Elisabeth S, Oberhuber, Georg, Bolik, Julia, Rehman, Ateequr, Sinha, Anupam, Lokau, Juliane, Arnold, Philipp, Cabron, Anne-Sophie, Zunke, Friederike, Becker-Pauly, Christoph, Preaudet, Adele, Nguyen, Paul, Huynh, Jennifer, Afshar-Sterle, Shoukat, Chand, Ashwini L, Westermann, Jürgen, Dempsey, Peter J, Garbers, Christoph, Schmidt-Arras, Dirk, Rosenstiel, Philip, Putoczki, Tracy, Ernst, Matthias, Rose-John, Stefan
Published in The Journal of experimental medicine (02.04.2018)
Published in The Journal of experimental medicine (02.04.2018)
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Journal Article
The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo
Kirschke, Sophia, Ogunsulire, Ireti, Selvakumar, Balachandar, Schumacher, Neele, Sezin, Tanya, Rose-John, Stefan, Scheffold, Alexander, Garbers, Christoph, Lokau, Juliane
Published in The Journal of biological chemistry (01.06.2022)
Published in The Journal of biological chemistry (01.06.2022)
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Journal Article
The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130
Müller, Stephan A, Shmueli, Merav D, Feng, Xiao, Tüshaus, Johanna, Schumacher, Neele, Clark, Ryan, Smith, Brad E, Chi, An, Rose-John, Stefan, Kennedy, Matthew E, Lichtenthaler, Stefan F
Published in Molecular neurodegeneration (21.02.2023)
Published in Molecular neurodegeneration (21.02.2023)
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A variant in IL6ST with a selective IL-11 signaling defect in human and mouse
Schwerd, Tobias, Krause, Freia, Twigg, Stephen R. F., Aschenbrenner, Dominik, Chen, Yin-Huai, Borgmeyer, Uwe, Müller, Miryam, Manrique, Santiago, Schumacher, Neele, Wall, Steven A., Jung, Jonathan, Damm, Timo, Glüer, Claus-Christian, Scheller, Jürgen, Rose-John, Stefan, Jones, E. Yvonne, Laurence, Arian, Wilkie, Andrew O. M., Schmidt-Arras, Dirk, Uhlig, Holm H.
Published in Bone Research (11.06.2020)
Published in Bone Research (11.06.2020)
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Journal Article
EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells
Schumacher, Neele, Thomsen, Ilka, Brundert, Florian, Hejret, Vaclav, Düsterhöft, Stefan, Tichý, Boris, Schmidt-Arras, Dirk, Voss, Matthias, Rose-John, Stefan
Published in Biochimica et biophysica acta. Molecular cell research (01.10.2023)
Published in Biochimica et biophysica acta. Molecular cell research (01.10.2023)
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Journal Article
Gut microbiota shape ‘inflamm-ageing’ cytokines and account for age-dependent decline in DNA damage repair
Guedj, Avital, Volman, Yael, Geiger-Maor, Anat, Bolik, Julia, Schumacher, Neele, Künzel, Sven, Baines, John F, Nevo, Yuval, Elgavish, Sharona, Galun, Eithan, Amsalem, Hagai, Schmidt-Arras, Dirk, Rachmilewitz, Jacob
Published in Gut (01.06.2020)
Published in Gut (01.06.2020)
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Journal Article
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis
Bolik, Julia, Krause, Freia, Stevanovic, Marija, Gandraß, Monja, Thomsen, Ilka, Schacht, Sarah-Sophie, Rieser, Eva, Müller, Miryam, Schumacher, Neele, Fritsch, Jürgen, Wichert, Rielana, Galun, Eithan, Bergmann, Juri, Röder, Christian, Schafmayer, Clemens, Egberts, Jan-Hendrik, Becker-Pauly, Christoph, Saftig, Paul, Lucius, Ralph, Schneider-Brachert, Wulf, Barikbin, Roja, Adam, Dieter, Voss, Matthias, Hitzl, Wolfgang, Krüger, Achim, Strilic, Boris, Sagi, Irit, Walczak, Henning, Rose-John, Stefan, Schmidt-Arras, Dirk
Published in The Journal of experimental medicine (03.01.2022)
Published in The Journal of experimental medicine (03.01.2022)
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Journal Article
Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN
Gleitz, Hélène F.E., Dugourd, Aurélien J.F., Leimkühler, Nils B., Snoeren, Inge A.M., Fuchs, Stijn N.R., Menzel, Sylvia, Ziegler, Susanne, Kröger, Nicolaus, Triviai, Ioanna, Büsche, Guntram, Kreipe, Hans, Banjanin, Bella, Pritchard, Jessica E., Hoogenboezem, Remco, Bindels, Eric M., Schumacher, Neele, Rose-John, Stefan, Elf, Shannon, Saez-Rodriguez, Julio, Kramann, Rafael, Schneider, Rebekka K.
Published in Blood (29.10.2020)
Published in Blood (29.10.2020)
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Journal Article
Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation
Heinig, Lisa Charlotte, Huth, Emily Valentina Madelaine, Yan, Karsten, Schumacher, Neele, Nawrocki, Mikolaj, Lory, Niels Christian, Bradtke, Peter, Bertram, Tabea, Rattay, Guido, Schmid, Joanna, Huber, Samuel, Wiech, Thorsten, Schmidt-Arras, Dirk, Rose-John, Stefan, Mittrücker, Hans-Willi
Published in The Journal of immunology (1950) (01.06.2023)
Published in The Journal of immunology (1950) (01.06.2023)
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Journal Article
Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling
Arnold, Philipp, Boll, Inga, Rothaug, Michelle, Schumacher, Neele, Schmidt, Frederike, Wichert, Rielana, Schneppenheim, Janna, Lokau, Juliane, Pickhinke, Ute, Koudelka, Tomas, Tholey, Andreas, Rabe, Björn, Scheller, Jürgen, Lucius, Ralph, Garbers, Christoph, Rose-John, Stefan, Becker-Pauly, Christoph
Published in Scientific reports (09.03.2017)
Published in Scientific reports (09.03.2017)
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Journal Article
ADAM17 controls IL‐6 signaling by cleavage of the murine IL‐6Rα from the cell surface of leukocytes during inflammatory responses
Yan, Isabell, Schwarz, Jeanette, Lücke, Karsten, Schumacher, Neele, Schumacher, Valéa, Schmidt, Stefanie, Rabe, Björn, Saftig, Paul, Donners, Marjo, Rose‐John, Stefan, Mittrücker, Hans‐Willi, Chalaris, Athena
Published in Journal of leukocyte biology (01.05.2016)
Published in Journal of leukocyte biology (01.05.2016)
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Journal Article
Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation
Schumacher, Neele, Schmidt, Stefanie, Schwarz, Jeanette, Dohr, Dana, Lokau, Juliane, Scheller, Jürgen, Garbers, Christoph, Chalaris, Athena, Rose-John, Stefan, Rabe, Björn
Published in The Journal of immunology (1950) (01.11.2016)
Published in The Journal of immunology (1950) (01.11.2016)
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Journal Article
Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice
Schumacher, Neele, Yan, Karsten, Gandraß, Monja, Müller, Miryam, Krisp, Christoph, Häsler, Robert, Carambia, Antonella, Nofer, Jerzy-Roch, Bernardes, Joanna P., Khouja, Mouhamad, Thomsen, Ilka, Chalupsky, Karel, Bolik, Julia, Hölscher, Christoph, Wunderlich, Thomas, Herkel, Johannes, Rosenstiel, Philip, Schramm, Christoph, Schlüter, Hartmut, Renné, Thomas, Mittrücker, Hans-Willi, Rose-John, Stefan, Schmidt-Arras, Dirk
Published in Journal of hepatology (01.02.2021)
Published in Journal of hepatology (01.02.2021)
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Journal Article
Proteolytic Cleavage Governs Interleukin-11 Trans-signaling
Lokau, Juliane, Nitz, Rebecca, Agthe, Maria, Monhasery, Niloufar, Aparicio-Siegmund, Samadhi, Schumacher, Neele, Wolf, Janina, Möller-Hackbarth, Katja, Waetzig, Georg H., Grötzinger, Joachim, Müller-Newen, Gerhard, Rose-John, Stefan, Scheller, Jürgen, Garbers, Christoph
Published in Cell reports (Cambridge) (23.02.2016)
Published in Cell reports (Cambridge) (23.02.2016)
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Journal Article
Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells
Cabron, Anne-Sophie, El Azzouzi, Karim, Boss, Melanie, Arnold, Philipp, Schwarz, Jeanette, Rosas, Marcela, Dobert, Jan Philipp, Pavlenko, Egor, Schumacher, Neele, Renné, Thomas, Taylor, Philip R, Linder, Stefan, Rose-John, Stefan, Zunke, Friederike
Published in The Journal of immunology (1950) (15.11.2018)
Published in The Journal of immunology (1950) (15.11.2018)
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Journal Article
Enzymatic characterization of novel arylsulfatase A variants using human arylsulfatase A‐deficient immortalized mesenchymal stromal cells
Böhringer, Judith, Santer, René, Schumacher, Neele, Gieseke, Friederike, Cornils, Kerstin, Pechan, Maria, Kustermann‐Kuhn, Birgit, Handgretinger, Rupert, Schöls, Ludger, Harzer, Klaus, Krägeloh‐Mann, Ingeborg, Müller, Ingo
Published in Human mutation (01.11.2017)
Published in Human mutation (01.11.2017)
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Journal Article
Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro
Bedau, Tillmann, Schumacher, Neele, Peters, Florian, Prox, Johannes, Arnold, Philipp, Koudelka, Tomas, Helm, Ole, Schmidt, Frederike, Rabe, Björn, Jentzsch, Marlene, Rosenstiel, Philip, Sebens, Susanne, Tholey, Andreas, Rose-John, Stefan, Becker-Pauly, Christoph
Published in Oncotarget (15.08.2017)
Published in Oncotarget (15.08.2017)
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