Development of a Three-Dimensional CysLT1 (LTD4) Antagonist Model with an Incorporated Amino Acid Residue from the Receptor
ZWAAGSTRA, Mariël E., SCHOENMAKERS, Saskia H. H. F., NEDERKOORN, Paul H. J., GELENS, Edith, TIMMERMAN, Henk, ZHANG, Ming-Qiang
Published in Journal of medicinal chemistry (23.04.1998)
Published in Journal of medicinal chemistry (23.04.1998)
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Development of a Pharmacophore Model for Histamine H3 Receptor Antagonists, Using the Newly Developed Molecular Modeling Program SLATE
De Esch, Iwan J. P, Mills, James E. J, Perkins, Tim D. J, Romeo, Giuseppe, Hoffmann, Marcel, Wieland, Kerstin, Leurs, Rob, Menge, Wiro M. P. B, Nederkoorn, Paul H. J, Dean, Philip M, Timmerman, Henk
Published in Journal of medicinal chemistry (24.05.2001)
Published in Journal of medicinal chemistry (24.05.2001)
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The ligand-receptor-G-protein ternary complex as a GTP-synthase. steady-state proton pumping and dose-response relationships for beta -adrenoceptors
Broadley, K J, Nederkoorn, P H, Timmerman, H, Timms, D, Davies, R H
Published in Journal of theoretical biology (21.07.2000)
Published in Journal of theoretical biology (21.07.2000)
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Characterization of the binding site of the histamine H(3) receptor. 2. Synthesis, in vitro pharmacology, and QSAR of a series of monosubstituted benzyl analogues of thioperamide
Windhorst, A D, Timmerman, H, Worthington, E A, Bijloo, G J, Nederkoorn, P H, Menge, W M, Leurs, R, Herscheid, J D
Published in Journal of medicinal chemistry (04.05.2000)
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Published in Journal of medicinal chemistry (04.05.2000)
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The agonistic binding site at the histamine H2 receptor. II. Theoretical investigations of histamine binding to receptor models of the seven alpha-helical transmembrane domain
Nederkoorn, P H, van Gelder, E M, Donné-Op den Kelder, G M, Timmerman, H
Published in Journal of computer-aided molecular design (01.10.1996)
Published in Journal of computer-aided molecular design (01.10.1996)
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The agonistic binding site at the histamine H2 receptor. I. Theoretical investigations of histamine binding to an oligopeptide mimicking a part of the fifth transmembrane alpha-helix
Nederkoorn, P H, van Lenthe, J H, van der Goot, H, Donné-Op den Kelder, G M, Timmerman, H
Published in Journal of computer-aided molecular design (01.10.1996)
Published in Journal of computer-aided molecular design (01.10.1996)
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Does the ternary complex act as a secondary proton pump and a GTP synthase?
Nederkoorn, P.H.J., Timmerman, H., den Kelder, G.M.Donné-Op
Published in Trends in pharmacological sciences (Regular ed.) (01.05.1995)
Published in Trends in pharmacological sciences (Regular ed.) (01.05.1995)
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Modelling and mutation studies on the histamine H1-receptor agonist binding site reveal different binding modes for H1-agonists: Asp116 (TM3) has a constitutive role in receptor stimulation
ter Laak, A M, Timmerman, H, Leurs, R, Nederkoorn, P H, Smit, M J, Donné-Op den Kelder, G M
Published in Journal of computer-aided molecular design (01.08.1995)
Published in Journal of computer-aided molecular design (01.08.1995)
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A new model for the agonistic binding site on the histamine H2-receptor: the catalytic triad in serine proteases as a model for the binding site of histamine H2-receptor agonists
Nederkoorn, P H, Vernooijs, P, Donné-Op den Kelder, G M, Baerends, E J, Timmerman, H
Published in Journal of molecular graphics (01.12.1994)
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Published in Journal of molecular graphics (01.12.1994)
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