Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
Moses, Michael A, Kim, Yeong Sang, Rivera-Marquez, Genesis M, Oshima, Nobu, Watson, Matthew J, Beebe, Kristin E, Wells, Catherine, Lee, Sunmin, Zuehlke, Abbey D, Shao, Hao, Bingman, 3rd, William E, Kumar, Vineet, Malhotra, Sanjay V, Weigel, Nancy L, Gestwicki, Jason E, Trepel, Jane B, Neckers, Leonard M
Published in Cancer research (Chicago, Ill.) (15.07.2018)
Published in Cancer research (Chicago, Ill.) (15.07.2018)
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Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma
Yeung, Choh, Gibson, Anna E, Issaq, Sameer H, Oshima, Nobu, Baumgart, Joshua T, Edessa, Leah D, Rai, Ganesha, Urban, Daniel J, Johnson, Michelle S, Benavides, Gloria A, Squadrito, Giuseppe L, Yohe, Marielle E, Lei, Haiyan, Eldridge, Sandy, Hamre, 3rd, John, Dowdy, Tyrone, Ruiz-Rodado, Victor, Lita, Adrian, Mendoza, Arnulfo, Shern, Jack F, Larion, Mioara, Helman, Lee J, Stott, Gordon M, Krishna, Murali C, Hall, Matthew D, Darley-Usmar, Victor, Neckers, Leonard M, Heske, Christine M
Published in Cancer research (Chicago, Ill.) (01.10.2019)
Published in Cancer research (Chicago, Ill.) (01.10.2019)
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Mitochondrial topoisomerase I (top1mt) is a novel limiting factor of doxorubicin cardiotoxicity
Khiati, Salim, Dalla Rosa, Ilaria, Sourbier, Carole, Ma, Xuefei, Rao, V Ashutosh, Neckers, Leonard M, Zhang, Hongliang, Pommier, Yves
Published in Clinical cancer research (15.09.2014)
Published in Clinical cancer research (15.09.2014)
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Dual inhibition of oxidative phosphorylation and glycolysis exerts a synergistic antitumor effect on colorectal and gastric cancer by creating energy depletion and preventing metabolic switch
Aisu, Yuki, Oshima, Nobu, Hyodo, Fuminori, Elhelaly, Abdelazim Elsayed, Masuo, Akihiko, Okada, Tomoaki, Hisamori, Shigeo, Tsunoda, Shigeru, Hida, Koya, Morimoto, Tomonori, Miyoshi, Hiroyuki, Taketo, Makoto M, Matsuo, Masayuki, Neckers, Leonard M, Sakai, Yoshiharu, Obama, Kazutaka
Published in PloS one (12.12.2024)
Published in PloS one (12.12.2024)
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Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity
Tsutsumi, Shinji, Mollapour, Mehdi, Prodromou, Chrisostomos, Lee, Chung-Tien, Panaretou, Barry, Yoshida, Soichiro, Mayer, Matthias P, Neckers, Leonard M
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2012)
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Mitochondrial chaperon TNF-receptor- associated protein 1 as a novel apoptotic regulator conferring susceptibility to Pneumocystis jirovecii pneumonia
Amali, Aseervatham Anusha, Paramasivam, Kathirvel, Huang, Chiung Hui, Joshi, Abhinav, Hirpara, Jayshree L, Ravikumar, Sharada, Sam, Qi Hui, Tan, Rachel Ying Min, Tan, Zhaohong, Kumar, Dilip, Neckers, Leonard M, Pervaiz, Shazib, Foo, Roger, Chan, Candice Y Y, Zhu, Jin, Lee, Cheryl, Chai, Louis Yi Ann
Published in Frontiers in immunology (19.08.2024)
Published in Frontiers in immunology (19.08.2024)
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Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy
Zhang, Ting, Yang, Xinrui, Xu, Wanping, Wang, Jing, Wu, Dawei, Hong, Zhixian, Yuan, Shengxian, Zeng, Zhen, Jia, Xiaodong, Lu, Shanshan, Safadi, Rifaat, Han, Sen, Yang, Zhihong, Neckers, Leonard M, Liangpunsakul, Suthat, Zhou, Weiping, Lu, Yinying
Published in Cancer biology & medicine (01.08.2021)
Published in Cancer biology & medicine (01.08.2021)
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Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells
De Leon, Johanny Tonos, Iwai, Aki, Feau, Clementine, Garcia, Yenni, Balsiger, Heather A, Storer, Cheryl L, Suro, Raquel M, Garza, Kristine M, Lee, Sunmin, Sang Kim, Yeong, Chen, Yu, Ning, Yang-Min, Riggs, Daniel L, Fletterick, Robert J, Guy, R. Kiplin, Trepel, Jane B, Neckers, Leonard M, Cox, Marc B
Published in Proceedings of the National Academy of Sciences - PNAS (19.07.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (19.07.2011)
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Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function
Jackson, Joseph W., Rivera‐Marquez, Genesis M., Beebe, Kristin, Tran, Andy D., Trepel, Jane B., Gestwicki, Jason E., Blagg, Brian S. J., Ohkubo, Shuichi, Neckers, Leonard M.
Published in Journal of thrombosis and haemostasis (01.05.2020)
Published in Journal of thrombosis and haemostasis (01.05.2020)
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NMR Methods for Determining Lipid Turnover via Stable Isotope Resolved Metabolomics
Lin, Penghui, Dai, Li, Crooks, Daniel R, Neckers, Leonard M, Higashi, Richard M, Fan, Teresa W-M, Lane, Andrew N
Published in Metabolites (29.03.2021)
Published in Metabolites (29.03.2021)
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Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8⁺ T cell stemness and antitumor immunity
Hermans, Dalton, Gautam, Sanjivan, García-Cañaveras, Juan C., Gromer, Daniel, Mitra, Suman, Spolski, Rosanne, Li, Peng, Christensen, Stephen, Nguyen, Rosa, Lin, Jian-Xin, Oh, Jangsuk, Du, Ning, Veenbergen, Sharon, Fioravanti, Jessica, Ebina-Shibuya, Risa, Bleck, Christopher, Neckers, Leonard M., Rabinowitz, Joshua D., Gattinoni, Luca, Leonard, Warren J.
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2020)
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The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition
Mishra, Sanket J, Liu, Weiya, Beebe, Kristin, Banerjee, Monimoy, Kent, Caitlin N, Munthali, Vitumbiko, Koren, John, Taylor, John A, Neckers, Leonard M, Holzbeierlein, Jeffrey, Blagg, Brian S. J
Published in Journal of medicinal chemistry (11.02.2021)
Published in Journal of medicinal chemistry (11.02.2021)
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Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription
Liu, Lixia, Deng, Yaotang, Zheng, Zhenming, Deng, Zihao, Zhang, Jinxin, Li, Jieyou, Liang, Manfeng, Zhou, Xueqiong, Tan, Wenchong, Yang, Hongjun, Neckers, Leonard M, Zou, Fei, Chen, Xuemei
Published in Molecular cancer therapeutics (01.10.2021)
Published in Molecular cancer therapeutics (01.10.2021)
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Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer
Cheng, Qing, Chang, Jeffrey T, Geradts, Joseph, Neckers, Leonard M, Haystead, Timothy, Spector, Neil L, Lyerly, H Kim
Published in Breast cancer research : BCR (17.04.2012)
Published in Breast cancer research : BCR (17.04.2012)
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Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)
Rai, Ganesha, Brimacombe, Kyle R, Mott, Bryan T, Urban, Daniel J, Hu, Xin, Yang, Shyh-Ming, Lee, Tobie D, Cheff, Dorian M, Kouznetsova, Jennifer, Benavides, Gloria A, Pohida, Katie, Kuenstner, Eric J, Luci, Diane K, Lukacs, Christine M, Davies, Douglas R, Dranow, David M, Zhu, Hu, Sulikowski, Gary, Moore, William J, Stott, Gordon M, Flint, Andrew J, Hall, Matthew D, Darley-Usmar, Victor M, Neckers, Leonard M, Dang, Chi V, Waterson, Alex G, Simeonov, Anton, Jadhav, Ajit, Maloney, David J
Published in Journal of medicinal chemistry (22.11.2017)
Published in Journal of medicinal chemistry (22.11.2017)
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Genome-Wide Analysis Identifies Nuclear Factor 1C as a Novel Transcription Factor and Potential Therapeutic Target in SCLC
Shukla, Vivek, Wang, Haitao, Varticovski, Lyuba, Baek, Songjoon, Wang, Ruihong, Wu, Xinwei, Echtenkamp, Frank, Villa-Hernandez, Frank, Prothro, Katherine P., Gara, Sudheer K., Zhang, Mary R., Shiffka, Stephanie, Raziuddin, Razi, Neckers, Leonard M., Linehan, W. Marston, Chen, Haobin, Hager, Gordon L., Schrump, David S.
Published in Journal of thoracic oncology (01.08.2024)
Published in Journal of thoracic oncology (01.08.2024)
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Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid
Frank, Anderson R, Li, Vicky, Shelton, Spencer D, Kim, Jiwoong, Stott, Gordon M, Neckers, Leonard M, Xie, Yang, Williams, Noelle S, Mishra, Prashant, McFadden, David G
Published in Cancer discovery (04.08.2023)
Published in Cancer discovery (04.08.2023)
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Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models
McKay-Corkum, Grace B, Collins, Victor J, Yeung, Choh, Ito, Takeshi, Issaq, Sameer H, Holland, David, Vulikh, Ksenia, Zhang, Yiping, Lee, Unsun, Lei, Haiyan, Mendoza, Arnulfo, Shern, Jack F, Yohe, Marielle E, Yamamoto, Kazutoshi, Wilson, Kelli, Ji, Jiuping, Karim, Baktiar O, Thomas, Craig J, Krishna, Murali C, Neckers, Leonard M, Heske, Christine M
Published in Clinical cancer research (01.11.2023)
Published in Clinical cancer research (01.11.2023)
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Computational Polypharmacology Analysis of the Heat Shock Protein 90 Interactome
Anighoro, Andrew, Stumpfe, Dagmar, Heikamp, Kathrin, Beebe, Kristin, Neckers, Leonard M, Bajorath, Jürgen, Rastelli, Giulio
Published in Journal of chemical information and modeling (23.03.2015)
Published in Journal of chemical information and modeling (23.03.2015)
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