Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors
Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H, Kennedy, Matthew E, Beyer, Brian M, Senior, Mary M, Smith, Elizabeth M, Nechuta, Terry L, Madison, Vincent S, Czarniecki, Michael, McKittrick, Brian A, Stamford, Andrew W, Parker, Eric M, Hunter, John C, Greenlee, William J, Wyss, Daniel F
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones—optimization, design and synthesis
Smith, Elizabeth M., Sorota, Steve, Kim, Hyunjin M., McKittrick, Brian A., Nechuta, Terry L., Bennett, Chad, Knutson, Chad, Burnett, Duane A., Kieselgof, Jane, Tan, Zheng, Rindgen, Diane, Bridal, Terry, Zhou, Xiaoping, Jia, Yu-Ping, Dong, Zoe, Mullins, Debbie, Zhang, Xiaoping, Priestley, Tony, Correll, Craig C., Tulshian, Deen, Czarniecki, Michael, Greenlee, William J.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors
Pissarnitski, Dmitri A., Asberom, Theodros, Bara, Thomas A., Buevich, Alex V., Clader, John W., Greenlee, William J., Guzik, Henry S., Josien, Hubert B., Li, Wei, McEwan, Michael, McKittrick, Brian A., Nechuta, Terry L., Parker, Eric M., Sinning, Lisa, Smith, Elizabeth M., Song, Lixin, Vaccaro, Henry A., Voigt, Johannes H., Zhang, Lili, Zhang, Qi, Zhao, Zhiqiang
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Mercaptoacyl aminoacid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives
Neustadt, Bernard R, Smith, Elizabeth M, Nechuta, Terry L, Bronnenkant, Alan A, Haslanger, Martin F, Watkins, Robert W, Foster, Caroline J, Sybertz, Edmund J
Published in Journal of medicinal chemistry (01.07.1994)
Published in Journal of medicinal chemistry (01.07.1994)
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Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel [mu]M Leads for the Development of nM BACE-1 ([beta]-Site APP Cleaving Enzyme 1) Inhibitors
Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H., Kennedy, Matthew E., Beyer, Brian M., Senior, Mary M., Smith, Elizabeth M., Nechuta, Terry L., Madison, Vincent S., Czarniecki, Michael, McKittrick, Brian A., Stamford, Andrew W., Parker, Eric M., Hunter, John C., Greenlee, William J., Wyss, Daniel F.
Published in Journal of medicinal chemistry (18.10.2010)
Published in Journal of medicinal chemistry (18.10.2010)
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Journal Article
Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors
Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H, Kennedy, Matthew E, Beyer, Brian M, Senior, Mary M, Smith, Elizabeth M, Nechuta, Terry L, Madison, Vincent S, Czarniecki, Michael, McKittrick, Brian A, Stamford, Andrew W, Parker, Eric M, Hunter, John C, Greenlee, William J, Wyss, Daniel F
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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MERCAPTOACYL AMINO-ACID INHIBITORS OF ATRIOPEPTIDASE .1. STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF METHIONINE AND S-ALKYLCYSTEINE DERIVATIVES
NEUSTADT, BR, SMITH, EM, NECHUTA, TL, BRONNENKANT, AA, HASLANGER, MF, WATKINS, RW, FOSTER, CJ, SYBERTZ, EJ
Published in Journal of medicinal chemistry (22.07.1994)
Published in Journal of medicinal chemistry (22.07.1994)
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