Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity
Sivick, Kelsey E., Desbien, Anthony L., Glickman, Laura Hix, Reiner, Gabrielle L., Corrales, Leticia, Surh, Natalie H., Hudson, Thomas E., Vu, Uyen T., Francica, Brian J., Banda, Tamara, Katibah, George E., Kanne, David B., Leong, Justin J., Metchette, Ken, Bruml, Jacob R., Ndubaku, Chudi O., McKenna, Jeffrey M., Feng, Yan, Zheng, Lianxing, Bender, Steven L., Cho, Charles Y., Leong, Meredith L., van Elsas, Andrea, Dubensky, Thomas W., McWhirter, Sarah M.
Published in Cell reports (Cambridge) (11.12.2018)
Published in Cell reports (Cambridge) (11.12.2018)
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Journal Article
Discovery of Selective 4‑Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization
Crawford, Terry D, Ndubaku, Chudi O, Chen, Huifen, Boggs, Jason W, Bravo, Brandon J, DeLaTorre, Kelly, Giannetti, Anthony M, Gould, Stephen E, Harris, Seth F, Magnuson, Steven R, McNamara, Erin, Murray, Lesley J, Nonomiya, Jim, Sambrone, Amy, Schmidt, Stephen, Smyczek, Tanya, Stanley, Mark, Vitorino, Philip, Wang, Lan, West, Kristina, Wu, Ping, Ye, Weilan
Published in Journal of medicinal chemistry (24.04.2014)
Published in Journal of medicinal chemistry (24.04.2014)
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Journal Article
NK cells mediate clearance of CD8 + T cell-resistant tumors in response to STING agonists
Nicolai, Christopher J, Wolf, Natalie, Chang, I-Chang, Kirn, Georgia, Marcus, Assaf, Ndubaku, Chudi O, McWhirter, Sarah M, Raulet, David H
Published in Science immunology (20.03.2020)
Published in Science immunology (20.03.2020)
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Journal Article
Synergy of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I-deficient and MHC I + tumors
Wolf, Natalie K, Blaj, Cristina, Picton, Lora K, Snyder, Gail, Zhang, Li, Nicolai, Christopher J, Ndubaku, Chudi O, McWhirter, Sarah M, Garcia, K Christopher, Raulet, David H
Published in Proceedings of the National Academy of Sciences - PNAS (31.05.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (31.05.2022)
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Journal Article
Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer
Kinkead, Heather L, Hopkins, Alexander, Lutz, Eric, Wu, Annie A, Yarchoan, Mark, Cruz, Kayla, Woolman, Skylar, Vithayathil, Teena, Glickman, Laura H, Ndubaku, Chudi O, McWhirter, Sarah M, Dubensky, Jr, Thomas W, Armstrong, Todd D, Jaffee, Elizabeth M, Zaidi, Neeha
Published in JCI insight (18.10.2018)
Published in JCI insight (18.10.2018)
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Journal Article
Discovery of 2‑{3-[2-(1-Isopropyl-3-methyl‑1H‑1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2‑d][1,4]oxazepin-9-yl]‑1H‑pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β‑Sparing Phosphoinositide 3‑Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity
Ndubaku, Chudi O, Heffron, Timothy P, Staben, Steven T, Baumgardner, Matthew, Blaquiere, Nicole, Bradley, Erin, Bull, Richard, Do, Steven, Dotson, Jennafer, Dudley, Danette, Edgar, Kyle A, Friedman, Lori S, Goldsmith, Richard, Heald, Robert A, Kolesnikov, Aleksandr, Lee, Leslie, Lewis, Cristina, Nannini, Michelle, Nonomiya, Jim, Pang, Jodie, Price, Steve, Prior, Wei Wei, Salphati, Laurent, Sideris, Steve, Wallin, Jeffery J, Wang, Lan, Wei, BinQing, Sampath, Deepak, Olivero, Alan G
Published in Journal of medicinal chemistry (13.06.2013)
Published in Journal of medicinal chemistry (13.06.2013)
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Journal Article
Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity
Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M, Park, Chang H, Boghaert, Erwin R, Catron, Nathaniel D, Chen, Jun, Colman, Peter M, Czabotar, Peter E, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Hymowitz, Sarah G, Jin, Sha, Judge, Russell A, Koehler, Michael F. T, Kovar, Peter J, Lessene, Guillaume, Mitten, Michael J, Ndubaku, Chudi O, Nimmer, Paul, Purkey, Hans E, Oleksijew, Anatol, Phillips, Darren C, Sleebs, Brad E, Smith, Brian J, Smith, Morey L, Tahir, Stephen K, Watson, Keith G, Xiao, Yu, Xue, John, Zhang, Haichao, Zobel, Kerry, Rosenberg, Saul H, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J
Published in ACS medicinal chemistry letters (09.10.2014)
Published in ACS medicinal chemistry letters (09.10.2014)
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Journal Article
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR
Heffron, Timothy P, Ndubaku, Chudi O, Salphati, Laurent, Alicke, Bruno, Cheong, Jonathan, Drobnick, Joy, Edgar, Kyle, Gould, Stephen E, Lee, Leslie B, Lesnick, John D, Lewis, Cristina, Nonomiya, Jim, Pang, Jodie, Plise, Emile G, Sideris, Steve, Wallin, Jeffrey, Wang, Lan, Zhang, Xiaolin, Olivero, Alan G
Published in ACS medicinal chemistry letters (14.04.2016)
Published in ACS medicinal chemistry letters (14.04.2016)
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Journal Article
Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window
Rudolph, Joachim, Murray, Lesley J, Ndubaku, Chudi O, O’Brien, Thomas, Blackwood, Elizabeth, Wang, Weiru, Aliagas, Ignacio, Gazzard, Lewis, Crawford, James J, Drobnick, Joy, Lee, Wendy, Zhao, Xianrui, Hoeflich, Klaus P, Favor, David A, Dong, Ping, Zhang, Haiming, Heise, Christopher E, Oh, Angela, Ong, Christy C, La, Hank, Chakravarty, Paroma, Chan, Connie, Jakubiak, Diana, Epler, Jennifer, Ramaswamy, Sreemathy, Vega, Roxanne, Cain, Gary, Diaz, Dolores, Zhong, Yu
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
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Journal Article
Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity
Sivick, Kelsey E., Desbien, Anthony L., Glickman, Laura Hix, Reiner, Gabrielle L., Corrales, Leticia, Surh, Natalie H., Hudson, Thomas E., Vu, Uyen T., Francica, Brian J., Banda, Tamara, Katibah, George E., Kanne, David B., Leong, Justin J., Metchette, Ken, Bruml, Jacob R., Ndubaku, Chudi O., McKenna, Jeffrey M., Feng, Yan, Zheng, Lianxing, Bender, Steven L., Cho, Charles Y., Leong, Meredith L., van Elsas, Andrea, Dubensky, Thomas W., McWhirter, Sarah M.
Published in Cell reports (Cambridge) (15.10.2019)
Published in Cell reports (Cambridge) (15.10.2019)
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Journal Article
Design of Selective PAK1 Inhibitor G‑5555: Improving Properties by Employing an Unorthodox Low‑pK a Polar Moiety
Ndubaku, Chudi O, Crawford, James J, Drobnick, Joy, Aliagas, Ignacio, Campbell, David, Dong, Ping, Dornan, Laura M, Duron, Sergio, Epler, Jennifer, Gazzard, Lewis, Heise, Christopher E, Hoeflich, Klaus P, Jakubiak, Diana, La, Hank, Lee, Wendy, Lin, Baiwei, Lyssikatos, Joseph P, Maksimoska, Jasna, Marmorstein, Ronen, Murray, Lesley J, O’Brien, Thomas, Oh, Angela, Ramaswamy, Sreemathy, Wang, Weiru, Zhao, Xianrui, Zhong, Yu, Blackwood, Elizabeth, Rudolph, Joachim
Published in ACS medicinal chemistry letters (10.12.2015)
Published in ACS medicinal chemistry letters (10.12.2015)
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Journal Article
Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis
Ndubaku, Chudi O, Crawford, Terry D, Chen, Huifen, Boggs, Jason W, Drobnick, Joy, Harris, Seth F, Jesudason, Rajiv, McNamara, Erin, Nonomiya, Jim, Sambrone, Amy, Schmidt, Stephen, Smyczek, Tanya, Vitorino, Philip, Wang, Lan, Wu, Ping, Yeung, Stacey, Chen, Jinhua, Chen, Kevin, Ding, Charles Z, Wang, Tao, Xu, Zijin, Gould, Stephen E, Murray, Lesley J, Ye, Weilan
Published in ACS medicinal chemistry letters (13.08.2015)
Published in ACS medicinal chemistry letters (13.08.2015)
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Journal Article
Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors
Wang, Lan, Stanley, Mark, Boggs, Jason W., Crawford, Terry D., Bravo, Brandon J., Giannetti, Anthony M., Harris, Seth F., Magnuson, Steven R., Nonomiya, Jim, Schmidt, Stephen, Wu, Ping, Ye, Weilan, Gould, Stephen E., Murray, Lesley J., Ndubaku, Chudi O., Chen, Huifen
Published in Bioorganic & medicinal chemistry letters (15.09.2014)
Published in Bioorganic & medicinal chemistry letters (15.09.2014)
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Journal Article
anti-1,2-Diols via Ni-Catalyzed Reductive Coupling of Alkynes and α-Oxyaldehydes
Luanphaisarnnont, Torsak, Ndubaku, Chudi O, Jamison, Timothy F
Published in Organic letters (07.07.2005)
Published in Organic letters (07.07.2005)
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Journal Article
Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pKa Polar Moiety
Ndubaku, Chudi O., Crawford, James J., Drobnick, Joy, Aliagas, Ignacio, Campbell, David, Dong, Ping, Dornan, Laura M., Duron, Sergio, Epler, Jennifer, Gazzard, Lewis, Heise, Christopher E., Hoeflich, Klaus P., Jakubiak, Diana, La, Hank, Lee, Wendy, Lin, Baiwei, Lyssikatos, Joseph P., Maksimoska, Jasna, Marmorstein, Ronen, Murray, Lesley J., O’Brien, Thomas, Oh, Angela, Ramaswamy, Sreemathy, Wang, Weiru, Zhao, Xianrui, Zhong, Yu, Blackwood, Elizabeth, Rudolph, Joachim
Published in ACS medicinal chemistry letters (31.10.2015)
Published in ACS medicinal chemistry letters (31.10.2015)
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Journal Article
ChemInform Abstract: A Versatile Annulation Route to Primary-Amino-Substituted Naphthyridine Esters
Chen, Jinhua, Xu, Zijin, Wang, Tao, Lyssikatos, Joseph P., Ndubaku, Chudi O.
Published in ChemInform (17.06.2014)
Published in ChemInform (17.06.2014)
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Journal Article
Abstract 1202: Tumor cell intrinsic STING signaling demonstrates minimal contribution to the anti-tumor response elicited by the STING agonist ADU-S100 (MIW815)
Corrales, Leticia, Desbien, Antony L., Gauthier, Kelsey E. Sivick, Deng, Weiwen, Schroeder, Tamara, Reiner, Gabrielle L., Surh, Natalie, Francica, Brian, Metchette, Ken, Ndubaku, Chudi O., McKenna, Jeffrey M., Feng, Yan, Zheng, Lianxing, Bender, Steven L., Cho, Charles Y., Elsas, Andrea van, Leong, Meredith L., McWhirter, Sarah M.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
A Versatile Annulation Route to Primary-Amino-Substituted Naphthyridine Esters
Chen, Jinhua, Xu, Zijin, Wang, Tao, Lyssikatos, Joseph P., Ndubaku, Chudi O.
Published in Synlett (02.01.2014)
Published in Synlett (02.01.2014)
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Journal Article
Abstract 2633: Discovery of novel, highly selective inhibitors of PLK4 that demonstrate in vivo regressions in TRIM37 high xenografts
Edgar, Kyle A., Young, Amy, Moore, Jared, Chen, Xi, Fang, Wei, Chang, Jae H., Kong, Wayne, Long, Jason E., Pankov, Aleksandr, Daemen, Anneleen, Shore, Daniel G., Warne, Robert, Gibbons, Paul, Ndubaku, Chudi O., Junttila, Melissa R., Friedman, Lori S.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 2074: ORIC-533, a small molecule CD73 inhibitor with best-in-class properties, reversesimmunosuppression and has potential as an immunomodulatory therapy in patients with multiple myeloma
Junttila, Melissa R., Ray, Arghya, Warne, Robert, Chen, Xi, Du, Ting, Sutimantanapi, Dena, Chang, Jae H., Blank, Brian, Moore, Jared, Ndubaku, Chudi O., Zavorotinskaya, Tatiana, Multani, Pratik, Nadeem, Omar, Chauhan, Dharminder, Anderson, Kenneth C., Friedman, Lori S.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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