Insights into the Role of Heme in the Mechanism of Action of Antimalarials
Combrinck, Jill M, Mabotha, Tebogo E, Ncokazi, Kanyile K, Ambele, Melvin A, Taylor, Dale, Smith, Peter J, Hoppe, Heinrich C, Egan, Timothy J
Published in ACS chemical biology (18.01.2013)
Published in ACS chemical biology (18.01.2013)
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Journal Article
The Antimalarial Ferroquine: Role of the Metal and Intramolecular Hydrogen Bond in Activity and Resistance
Dubar, Faustine, Egan, Timothy J, Pradines, Bruno, Kuter, David, Ncokazi, Kanyile K, Forge, Delphine, Paul, Jean-François, Pierrot, Christine, Kalamou, Hadidjatou, Khalife, Jamal, Buisine, Eric, Rogier, Christophe, Vezin, Hervé, Forfar, Isabelle, Slomianny, Christian, Trivelli, Xavier, Kapishnikov, Sergey, Leiserowitz, Leslie, Dive, Daniel, Biot, Christophe
Published in ACS chemical biology (18.03.2011)
Published in ACS chemical biology (18.03.2011)
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Journal Article
Haemozoin (β-haematin) biomineralization occurs by self-assembly near the lipid/water interface
Egan, Timothy J., Chen, Jeff Y-J., de Villiers, Katherine A., Mabotha, Tebogo E., Naidoo, Kevin J., Ncokazi, Kanyile K., Langford, Steven J., McNaughton, Don, Pandiancherri, Shveta, Wood, Bayden R.
Published in FEBS letters (18.09.2006)
Published in FEBS letters (18.09.2006)
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Journal Article
Crystallization of synthetic haemozoin (beta-haematin) nucleated at the surface of lipid particles
Hoang, Anh N, Ncokazi, Kanyile K, de Villiers, Katherine A, Wright, David W, Egan, Timothy J
Published in Dalton transactions : an international journal of inorganic chemistry (01.01.2010)
Published in Dalton transactions : an international journal of inorganic chemistry (01.01.2010)
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Journal Article
Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds
Guantai, Eric M., Ncokazi, Kanyile, Egan, Timothy J., Gut, Jiri, Rosenthal, Philip J., Smith, Peter J., Chibale, Kelly
Published in Bioorganic & medicinal chemistry (01.12.2010)
Published in Bioorganic & medicinal chemistry (01.12.2010)
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Journal Article
Enone– and Chalcone–Chloroquinoline Hybrid Analogues: In Silico Guided Design, Synthesis, Antiplasmodial Activity, in Vitro Metabolism, and Mechanistic Studies
Guantai, Eric M, Ncokazi, Kanyile, Egan, Timothy J, Gut, Jiri, Rosenthal, Philip J, Bhampidipati, Ravi, Kopinathan, Anitha, Smith, Peter J, Chibale, Kelly
Published in Journal of medicinal chemistry (26.05.2011)
Published in Journal of medicinal chemistry (26.05.2011)
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Journal Article
Effects of highly active novel artemisinin–chloroquinoline hybrid compounds on β-hematin formation, parasite morphology and endocytosis in Plasmodium falciparum
Feng, Tzu-Shean, Guantai, Eric M., Nell, Margo, van Rensburg, Constance E.J., Ncokazi, Kanyile, Egan, Timothy J., Hoppe, Heinrich C., Chibale, Kelly
Published in Biochemical pharmacology (01.08.2011)
Published in Biochemical pharmacology (01.08.2011)
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Journal Article
Reversed Chloroquines Based on the 3,4‐Dihydropyrimidin‐2(1H)‐one Scaffold: Synthesis and Evaluation for Antimalarial, β‐Haematin Inhibition, and Cytotoxic Activity
October, Natasha, Watermeyer, Nicholas D., Yardley, Vanessa, Egan, Timothy J., Ncokazi, Kanyile, Chibale, Kelly
Published in ChemMedChem (17.11.2008)
Published in ChemMedChem (17.11.2008)
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Journal Article
Antiplasmodial, beta-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines
Musonda, Chitalu C., Yardley, Vanessa, de Souza, Renata C. Carvalho, Ncokazi, Kanyile, Egan, Timothy J., Chibale, Kelly
Published in Organic & biomolecular chemistry (01.01.2008)
Published in Organic & biomolecular chemistry (01.01.2008)
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Journal Article
Reversed Chloroquines Based on the 3,4-Dihydropyrimidin-2(1H)-one Scaffold: Synthesis and Evaluation for Antimalarial, b-Haematin Inhibition, and Cytotoxic Activity
October, Natasha, Watermeyer, Nicholas D, Yardley, Vanessa, Egan, Timothy J, Ncokazi, Kanyile, Chibale, Kelly
Published in ChemMedChem (17.11.2008)
Published in ChemMedChem (17.11.2008)
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Journal Article