Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers
Soula, Mariluz, Weber, Ross A, Zilka, Omkar, Alwaseem, Hanan, La, Konnor, Yen, Frederick, Molina, Henrik, Garcia-Bermudez, Javier, Pratt, Derek A, Birsoy, Kıvanç
Published in Nature chemical biology (01.12.2020)
Published in Nature chemical biology (01.12.2020)
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MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
Coll, Rebecca C, Hill, James R, Day, Christopher J, Zamoshnikova, Alina, Boucher, Dave, Massey, Nicholas L, Chitty, Jessica L, Fraser, James A, Jennings, Michael P, Robertson, Avril A B, Schroder, Kate
Published in Nature chemical biology (01.06.2019)
Published in Nature chemical biology (01.06.2019)
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A computational framework to explore large-scale biosynthetic diversity
Navarro-Muñoz, Jorge C, Selem-Mojica, Nelly, Mullowney, Michael W, Kautsar, Satria A, Tryon, James H, Parkinson, Elizabeth I, De Los Santos, Emmanuel L C, Yeong, Marley, Cruz-Morales, Pablo, Abubucker, Sahar, Roeters, Arne, Lokhorst, Wouter, Fernandez-Guerra, Antonio, Cappelini, Luciana Teresa Dias, Goering, Anthony W, Thomson, Regan J, Metcalf, William W, Kelleher, Neil L, Barona-Gomez, Francisco, Medema, Marnix H
Published in Nature chemical biology (01.01.2020)
Published in Nature chemical biology (01.01.2020)
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Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis
Zou, Yilong, Li, Haoxin, Graham, Emily T, Deik, Amy A, Eaton, John K, Wang, Wenyu, Sandoval-Gomez, Gerardo, Clish, Clary B, Doench, John G, Schreiber, Stuart L
Published in Nature chemical biology (01.03.2020)
Published in Nature chemical biology (01.03.2020)
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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Doll, Sebastian, Proneth, Bettina, Tyurina, Yulia Y, Panzilius, Elena, Kobayashi, Sho, Ingold, Irina, Irmler, Martin, Beckers, Johannes, Aichler, Michaela, Walch, Axel, Prokisch, Holger, Trümbach, Dietrich, Mao, Gaowei, Qu, Feng, Bayir, Hulya, Füllekrug, Joachim, Scheel, Christina H, Wurst, Wolfgang, Schick, Joel A, Kagan, Valerian E, Angeli, José Pedro Friedmann, Conrad, Marcus
Published in Nature chemical biology (01.01.2017)
Published in Nature chemical biology (01.01.2017)
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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Kagan, Valerian E, Mao, Gaowei, Qu, Feng, Angeli, Jose Pedro Friedmann, Doll, Sebastian, Croix, Claudette St, Dar, Haider Hussain, Liu, Bing, Tyurin, Vladimir A, Ritov, Vladimir B, Kapralov, Alexandr A, Amoscato, Andrew A, Jiang, Jianfei, Anthonymuthu, Tamil, Mohammadyani, Dariush, Yang, Qin, Proneth, Bettina, Klein-Seetharaman, Judith, Watkins, Simon, Bahar, Ivet, Greenberger, Joel, Mallampalli, Rama K, Stockwell, Brent R, Tyurina, Yulia Y, Conrad, Marcus, Bayır, Hülya
Published in Nature chemical biology (01.01.2017)
Published in Nature chemical biology (01.01.2017)
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Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death
Kapralov, Alexandr A, Yang, Qin, Dar, Haider H, Tyurina, Yulia Y, Anthonymuthu, Tamil S, Kim, Rina, St Croix, Claudette M, Mikulska-Ruminska, Karolina, Liu, Bing, Shrivastava, Indira H, Tyurin, Vladimir A, Ting, Hsiu-Chi, Wu, Yijen L, Gao, Yuan, Shurin, Galina V, Artyukhova, Margarita A, Ponomareva, Liubov A, Timashev, Peter S, Domingues, Rosario M, Stoyanovsky, Detcho A, Greenberger, Joel S, Mallampalli, Rama K, Bahar, Ivet, Gabrilovich, Dmitry I, Bayır, Hülya, Kagan, Valerian E
Published in Nature chemical biology (01.03.2020)
Published in Nature chemical biology (01.03.2020)
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LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation
Ahn, Green, Banik, Steven M, Miller, Caitlyn L, Riley, Nicholas M, Cochran, Jennifer R, Bertozzi, Carolyn R
Published in Nature chemical biology (01.09.2021)
Published in Nature chemical biology (01.09.2021)
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TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
Olsen, Reid H J, DiBerto, Jeffrey F, English, Justin G, Glaudin, Alexis M, Krumm, Brian E, Slocum, Samuel T, Che, Tao, Gavin, Ariana C, McCorvy, John D, Roth, Bryan L, Strachan, Ryan T
Published in Nature chemical biology (01.08.2020)
Published in Nature chemical biology (01.08.2020)
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FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation
Gaschler, Michael M., Andia, Alexander A., Liu, Hengrui, Csuka, Joleen M., Hurlocker, Brisa, Vaiana, Christopher A., Heindel, Daniel W., Zuckerman, Dylan S., Bos, Pieter H., Reznik, Eduard, Ye, Ling F., Tyurina, Yulia Y., Lin, Annie J., Shchepinov, Mikhail S., Chan, Amy Y., Peguero-Pereira, Eveliz, Fomich, Maksim A., Daniels, Jacob. D., Bekish, Andrei V., Shmanai, Vadim V., Kagan, Valerian E., Mahal, Lara K., Woerpel, K. A., Stockwell, Brent R.
Published in Nature chemical biology (01.05.2018)
Published in Nature chemical biology (01.05.2018)
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The dTAG system for immediate and target-specific protein degradation
Nabet, Behnam, Roberts, Justin M, Buckley, Dennis L, Paulk, Joshiawa, Dastjerdi, Shiva, Yang, Annan, Leggett, Alan L, Erb, Michael A, Lawlor, Matthew A, Souza, Amanda, Scott, Thomas G, Vittori, Sarah, Perry, Jennifer A, Qi, Jun, Winter, Georg E, Wong, Kwok-Kin, Gray, Nathanael S, Bradner, James E
Published in Nature chemical biology (01.05.2018)
Published in Nature chemical biology (01.05.2018)
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How many human proteoforms are there?
Aebersold, Ruedi, Agar, Jeffrey N, Amster, I Jonathan, Baker, Mark S, Bertozzi, Carolyn R, Boja, Emily S, Costello, Catherine E, Cravatt, Benjamin F, Fenselau, Catherine, Garcia, Benjamin A, Ge, Ying, Gunawardena, Jeremy, Hendrickson, Ronald C, Hergenrother, Paul J, Huber, Christian G, Ivanov, Alexander R, Jensen, Ole N, Jewett, Michael C, Kelleher, Neil L, Kiessling, Laura L, Krogan, Nevan J, Larsen, Martin R, Loo, Joseph A, Ogorzalek Loo, Rachel R, Lundberg, Emma, MacCoss, Michael J, Mallick, Parag, Mootha, Vamsi K, Mrksich, Milan, Muir, Tom W, Patrie, Steven M, Pesavento, James J, Pitteri, Sharon J, Rodriguez, Henry, Saghatelian, Alan, Sandoval, Wendy, Schlüter, Hartmut, Sechi, Salvatore, Slavoff, Sarah A, Smith, Lloyd M, Snyder, Michael P, Thomas, Paul M, Uhlén, Mathias, Van Eyk, Jennifer E, Vidal, Marc, Walt, David R, White, Forest M, Williams, Evan R, Wohlschlager, Therese, Wysocki, Vicki H, Yates, Nathan A, Young, Nicolas L, Zhang, Bing
Published in Nature chemical biology (14.02.2018)
Published in Nature chemical biology (14.02.2018)
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Structural basis of PROTAC cooperative recognition for selective protein degradation
Gadd, Morgan S, Testa, Andrea, Lucas, Xavier, Chan, Kwok-Ho, Chen, Wenzhang, Lamont, Douglas J, Zengerle, Michael, Ciulli, Alessio
Published in Nature chemical biology (01.05.2017)
Published in Nature chemical biology (01.05.2017)
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BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Farnaby, William, Koegl, Manfred, Roy, Michael J, Whitworth, Claire, Diers, Emelyne, Trainor, Nicole, Zollman, David, Steurer, Steffen, Karolyi-Oezguer, Jale, Riedmueller, Carina, Gmaschitz, Teresa, Wachter, Johannes, Dank, Christian, Galant, Michael, Sharps, Bernadette, Rumpel, Klaus, Traxler, Elisabeth, Gerstberger, Thomas, Schnitzer, Renate, Petermann, Oliver, Greb, Peter, Weinstabl, Harald, Bader, Gerd, Zoephel, Andreas, Weiss-Puxbaum, Alexander, Ehrenhöfer-Wölfer, Katharina, Wöhrle, Simon, Boehmelt, Guido, Rinnenthal, Joerg, Arnhof, Heribert, Wiechens, Nicola, Wu, Meng-Ying, Owen-Hughes, Tom, Ettmayer, Peter, Pearson, Mark, McConnell, Darryl B, Ciulli, Alessio
Published in Nature chemical biology (01.07.2019)
Published in Nature chemical biology (01.07.2019)
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Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal
Sun, Wan-Yang, Tyurin, Vladimir A., Mikulska-Ruminska, Karolina, Shrivastava, Indira H., Anthonymuthu, Tamil S., Zhai, Yu-Jia, Pan, Ming-Hai, Gong, Hai-Biao, Lu, Dan-Hua, Sun, Jie, Duan, Wen-Jun, Korolev, Sergey, Abramov, Andrey Y., Angelova, Plamena R., Miller, Ian, Beharier, Ofer, Mao, Gao-Wei, Dar, Haider H., Kapralov, Alexandr A., Amoscato, Andrew A., Hastings, Teresa G., Greenamyre, Timothy J., Chu, Charleen T., Sadovsky, Yoel, Bahar, Ivet, Bayır, Hülya, Tyurina, Yulia Y., He, Rong-Rong, Kagan, Valerian E.
Published in Nature chemical biology (01.04.2021)
Published in Nature chemical biology (01.04.2021)
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Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles
Eaton, John K, Furst, Laura, Ruberto, Richard A, Moosmayer, Dieter, Hilpmann, André, Ryan, Matthew J, Zimmermann, Katja, Cai, Luke L, Niehues, Michael, Badock, Volker, Kramm, Anneke, Chen, Sixun, Hillig, Roman C, Clemons, Paul A, Gradl, Stefan, Montagnon, Claire, Lazarski, Kiel E, Christian, Sven, Bajrami, Besnik, Neuhaus, Roland, Eheim, Ashley L, Viswanathan, Vasanthi S, Schreiber, Stuart L
Published in Nature chemical biology (01.05.2020)
Published in Nature chemical biology (01.05.2020)
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Mitochondrial metabolism promotes adaptation to proteotoxic stress
Tsvetkov, Peter, Detappe, Alexandre, Cai, Kai, Keys, Heather R, Brune, Zarina, Ying, Weiwen, Thiru, Prathapan, Reidy, Mairead, Kugener, Guillaume, Rossen, Jordan, Kocak, Mustafa, Kory, Nora, Tsherniak, Aviad, Santagata, Sandro, Whitesell, Luke, Ghobrial, Irene M, Markley, John L, Lindquist, Susan, Golub, Todd R
Published in Nature chemical biology (01.07.2019)
Published in Nature chemical biology (01.07.2019)
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Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
Zhang, Xiaoyu, Crowley, Vincent M, Wucherpfennig, Thomas G, Dix, Melissa M, Cravatt, Benjamin F
Published in Nature chemical biology (01.07.2019)
Published in Nature chemical biology (01.07.2019)
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