PSGL-1 decorated with sialyl Lewisa/x promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement
O’Dwyer, Michael, Kirkham-McCarthy, Lucy, Cerreto, Marina, Foà, Robin, Natoni, Alessandro
Published in Scientific reports (19.01.2024)
Published in Scientific reports (19.01.2024)
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Journal Article
Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model
Natoni, Alessandro, Farrell, Mariah L, Harris, Sophie, Falank, Carolyne, Kirkham-McCarthy, Lucy, Macauley, Matthew S, Reagan, Michaela R, O'Dwyer, Michael
Published in Haematologica (Roma) (01.02.2020)
Published in Haematologica (Roma) (01.02.2020)
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Journal Article
Sialylation regulates migration in chronic lymphocytic leukemia
Natoni, Alessandro, Cerreto, Marina, De Propris, Maria Stefania, Del Giudice, Ilaria, Soscia, Roberta, Peragine, Nadia, Intoppa, Stefania, Milani, Maria Laura, Guarini, Anna, Foà, Robin
Published in Haematologica (Roma) (01.07.2023)
Published in Haematologica (Roma) (01.07.2023)
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Journal Article
The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma
Glavey, Siobhan V., Manier, Salomon, Natoni, Alessandro, Sacco, Antonio, Moschetta, Michele, Reagan, Michaela R., Murillo, Laura S., Sahin, Ilyas, Wu, Ping, Mishima, Yuji, Zhang, Yu, Zhang, Wenjing, Zhang, Yong, Morgan, Gareth, Joshi, Lokesh, Roccaro, Aldo M., Ghobrial, Irene M., O'Dwyer, Michael E.
Published in Blood (11.09.2014)
Published in Blood (11.09.2014)
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Journal Article
Hypersialylation and multiple myeloma
O’Dwyer, Michael, Glavey, Siobhan, McAvera, Roisin, Natoni, Alessandro, Ryan, Aideen E.
Published in Frontiers in hematology (19.02.2024)
Published in Frontiers in hematology (19.02.2024)
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Journal Article
Sialofucosylation Enables Platelet Binding to Myeloma Cells via P-Selectin and Suppresses NK Cell-Mediated Cytotoxicity
Natoni, Alessandro, Cerreto, Marina, De Propris, Maria Stefania, Petrucci, Maria Teresa, Fazio, Francesca, Intoppa, Stefania, Milani, Maria Laura, Kirkham-McCarthy, Lucy, Henderson, Robert, Swan, Dawn, Guarini, Anna, O'Dwyer, Michael, Foà, Robin
Published in Cancers (01.04.2023)
Published in Cancers (01.04.2023)
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Journal Article
The CD38low natural killer cell line KHYG1 transiently expressing CD16F158V in combination with daratumumab targets multiple myeloma cells with minimal effector NK cell fratricide
Sarkar, Subhashis, Chauhan, Sachin K. S., Daly, John, Natoni, Alessandro, Fairfield, Heather, Henderson, Robert, Nolan, Emma, Swan, Dawn, Hu, Jinsong, Reagan, Michaela R., O’Dwyer, Michael
Published in Cancer Immunology, Immunotherapy (01.03.2020)
Published in Cancer Immunology, Immunotherapy (01.03.2020)
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Journal Article
Cyclophosphamide alters the tumor cell secretome to potentiate the anti-myeloma activity of daratumumab through augmentation of macrophage-mediated antibody dependent cellular phagocytosis
Naicker, Serika D, Feerick, Claire L, Lynch, Kevin, Swan, Dawn, McEllistrim, Cian, Henderson, Robert, Leonard, Niamh A, Treacy, Oliver, Natoni, Alessandro, Rigalou, Athina, Cabral, Joana, Chiu, Christopher, Sasser, Kate, Ritter, Thomas, O'Dwyer, Michael, Ryan, Aideen E
Published in Oncoimmunology (01.01.2021)
Published in Oncoimmunology (01.01.2021)
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Journal Article
Calicivirus translation initiation requires an interaction between VPg and eIF4E
Goodfellow, Ian, Chaudhry, Yasmin, Gioldasi, Ioanna, Gerondopoulos, Andreas, Natoni, Alessandro, Labrie, Louisette, Laliberté, Jean-François, Roberts, Lisa
Published in EMBO reports (01.10.2005)
Published in EMBO reports (01.10.2005)
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Journal Article
Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells
Natoni, Alessandro, Murillo, Laura S, Kliszczak, Anna E, Catherwood, Mark A, Montagnoli, Alessia, Samali, Afshin, O'Dwyer, Michael, Santocanale, Corrado
Published in Molecular cancer therapeutics (01.09.2011)
Published in Molecular cancer therapeutics (01.09.2011)
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A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response
FitzGerald, Jennifer, Murillo, Laura S, O'Brien, Gemma, O'Connell, Enda, O'Connor, Aisling, Wu, Kevin, Wang, Guan-Nan, Rainey, Michael D, Natoni, Alessandro, Healy, Sandra, O'Dwyer, Michael, Santocanale, Corrado
Published in PloS one (05.06.2014)
Published in PloS one (05.06.2014)
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Journal Article
Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models
Natoni, Alessandro, Coyne, Mark R E, Jacobsen, Alan, Rainey, Michael D, O'Brien, Gemma, Healy, Sandra, Montagnoli, Alessia, Moll, Jürgen, O'Dwyer, Michael, Santocanale, Corrado
Published in Cancers (24.07.2013)
Published in Cancers (24.07.2013)
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Journal Article
Hypersialylation Protects Multiple Myeloma Cells from NK Cell-Mediated Immunosurveillance and This Can be Overcome By Targeted Desialylation Using a Sialyltransferase Inhibitor
Daly, John, Sarkar, Subhashis, Natoni, Alessandro, Henderson, Robert, Swan, Dawn, Carlsten, Mattias, O'Dwyer, Michael E
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Targeting Selectins and Their Ligands in Cancer
Natoni, Alessandro, Macauley, Matthew S, O'Dwyer, Michael E
Published in Frontiers in oncology (18.04.2016)
Published in Frontiers in oncology (18.04.2016)
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Journal Article
Inhibition of Sialylation Impairs Adhesion on Madcam-1 and E-Selectin and Sensitize Multiple Myeloma Cells to Bortezomib in a Xenograft Mouse Model
Natoni, Alessandro, Farrell, Mariah, Fairfield, Heather, Kirkham-McCarthy, Lucy, Macauley, Matt, Reagan, Michaela, O'Dwyer, Michael E
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Platelets Preferentially Bind to Myeloma Cells Bearing Sialofucosylated Structures and Protect Them from Natural Killer Cell-Mediated Cytotoxicity
Henderson, Robert, Kirkham-McCarthy, Lucy, Swan, Dawn, O'Dwyer, Michael E, Natoni, Alessandro
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article