A New Class of Antibody-Drug Conjugates with Potent DNA Alkylating Activity
Miller, Michael L, Fishkin, Nathan E, Li, Wei, Whiteman, Kathleen R, Kovtun, Yelena, Reid, Emily E, Archer, Katie E, Maloney, Erin K, Audette, Charlene A, Mayo, Michele F, Wilhelm, Alan, Modafferi, Holly A, Singh, Rajeeva, Pinkas, Jan, Goldmacher, Victor, Lambert, John M, Chari, Ravi V J
Published in Molecular cancer therapeutics (01.08.2016)
Published in Molecular cancer therapeutics (01.08.2016)
Get full text
Journal Article
all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model
Kim, So R, Jang, Young P, Jockusch, Steffen, Fishkin, Nathan E, Turro, Nicholas J, Sparrow, Janet R
Published in Proceedings of the National Academy of Sciences - PNAS (04.12.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (04.12.2007)
Get full text
Journal Article
Isolation and Characterization of a Retinal Pigment Epithelial Cell Fluorophore: An All-Trans-Retinal Dimer Conjugate
Fishkin, Nathan E., Sparrow, Janet R., Allikmets, Rando, Nakanishi, Koji, Nathans, Jeremy
Published in Proceedings of the National Academy of Sciences - PNAS (17.05.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (17.05.2005)
Get full text
Journal Article
Effect of Linker Stereochemistry on the Activity of Indolinobenzodiazepine Containing Antibody–Drug Conjugates (ADCs)
Reid, Emily E, Archer, Katie E, Shizuka, Manami, Wilhelm, Alan, Yoder, Nicholas C, Bai, Chen, Fishkin, Nathan E, Harris, Luke, Maloney, Erin K, Salomon, Paulin, Hong, Erica, Wu, Rui, Ab, Olga, Jin, Shan, Lai, Katharine C, Sikka, Surina, Chari, Ravi V. J, Miller, Michael L
Published in ACS medicinal chemistry letters (08.08.2019)
Published in ACS medicinal chemistry letters (08.08.2019)
Get full text
Journal Article
Rpe65 Leu450Met Variant Is Associated with Reduced Levels of the Retinal Pigment Epithelium Lipofuscin Fluorophores A2E and Iso-A2E
Kim, So Ra, Fishkin, Nathan, Kong, Jian, Nakanishi, Koji, Allikmets, Rando, Sparrow, Janet R., Turro, Nicholas J.
Published in Proceedings of the National Academy of Sciences - PNAS (10.08.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (10.08.2004)
Get full text
Journal Article
Biosynthetic Studies of A2E, a Major Fluorophore of Retinal Pigment Epithelial Lipofuscin
Ben-Shabat, Shimon, Parish, Craig A., Vollmer, Heidi R., Itagaki, Yasuhiro, Fishkin, Nathan, Nakanishi, Koji, Sparrow, Janet R.
Published in The Journal of biological chemistry (01.03.2002)
Published in The Journal of biological chemistry (01.03.2002)
Get full text
Journal Article
Design and synthesis of artificial phospholipid for selective cleavage of integral membrane protein
Furuta, T, Sakai, M, Hayashi, H, Asakawa, T, Kataoka, F, Fujii, S, Suzuki, T, Suzuki, Y, Tanaka, K, Fishkin, N, Nakanishi, K
Published in Chemical communications (Cambridge, England) (28.09.2005)
Published in Chemical communications (Cambridge, England) (28.09.2005)
Get more information
Journal Article
Targeted Maytansinoid Conjugate Improves Therapeutic Index for Metastatic Breast Cancer Cells
Jiang, Zhengyang, Yang, Zhen, Li, Feng, Li, Zheng, Fishkin, Nathan, Burgess, Kevin
Published in Bioconjugate chemistry (19.09.2018)
Published in Bioconjugate chemistry (19.09.2018)
Get full text
Journal Article
ORM-6151: A First-in-Class, Anti-CD33 Antibody-Enabled GSPT1 Degrader for AML
Palacino, James, Lee, Pedro, Jeong, Hangyeol, Kim, Yeonjoon, Song, Yoojin, Permpoon, Uttapol, Wong, Wesley, Bai, Chen, Fishkin, Nathan, Takrouri, Khuloud, Yu, Eunjin, Yi, Yong, Skaletskaya, Anna, Chang, Ki-Hwan, Kim, Min-Soo, Kim, Da-Yeong, Choi, Dong-Ki, Park, Peter U
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
Get full text
Journal Article
Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody–Maytansinoid Conjugates
Ponte, Jose F, Sun, Xiuxia, Yoder, Nicholas C, Fishkin, Nathan, Laleau, Rassol, Coccia, Jennifer, Lanieri, Leanne, Bogalhas, Megan, Wang, Lintao, Wilhelm, Sharon, Widdison, Wayne, Pinkas, Jan, Keating, Thomas A, Chari, Ravi, Erickson, Hans K, Lambert, John M
Published in Bioconjugate chemistry (20.07.2016)
Published in Bioconjugate chemistry (20.07.2016)
Get full text
Journal Article
IMGN779, a CD33-Targeted Antibody-Drug Conjugate (ADC) with a Novel DNA-Alkylating Effector Molecule, Induces DNA Damage, Cell Cycle Arrest, and Apoptosis in AML Cells
Krystal, Watkins M, Walker, Russell, Fishkin, Nathan, Audette, Charlene, Kovtun, Yelena, Romanelli, Angela
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
Get full text
Journal Article
Enzymatic Degradation of A2E, a Retinal Pigment Epithelial Lipofuscin Bisretinoid
Wu, Yalin, Zhou, Jilin, Fishkin, Nathan, Rittmann, Bruce E, Sparrow, Janet R
Published in Journal of the American Chemical Society (02.02.2011)
Published in Journal of the American Chemical Society (02.02.2011)
Get full text
Journal Article
Abstract 653: Antibody-drug conjugates: engineered N-terminal serine residues as a novel approach for site-specific conjugation
Tavares, Daniel, Rui, Lingyun, Ab, Olga, Harris, Luke, Maloney, Erin, Keating, Thomas, Chittenden, Thomas, Fishkin, Nathan
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article