Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner
Tabak, Galit, Keren-Raifman, Tal, Kahanovitch, Uri, Dascal, Nathan
Published in Scientific reports (24.01.2019)
Published in Scientific reports (24.01.2019)
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Journal Article
Movement of 'gating charge' is coupled to ligand binding in a G-protein-coupled receptor
Parnas, Hanna, Ben-Chaim, Yair, Chanda, Baron, Dascal, Nathan, Bezanilla, Francisco, Parnas, Itzchak
Published in Nature (London) (02.11.2006)
Published in Nature (London) (02.11.2006)
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Journal Article
SK4 Ca²⁺ activated K⁺ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells
Weisbrod, David, Peretz, Asher, Ziskind, Anna, Menaker, Nataly, Oz, Shimrit, Barad, Lili, Eliyahu, Sivan, Itskovitz-Eldor, Joseph, Dascal, Nathan, Khananshvili, Daniel, Binah, Ofer, Attali, Bernard
Published in Proceedings of the National Academy of Sciences - PNAS (30.04.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (30.04.2013)
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Journal Article
Dual regulation of G proteins and the G-protein–activated K⁺ channels by lithium
Tselnicker, Isabella Farhy, Tsemakhovich, Vladimir, Rishal, Ida, Kahanovitch, Uri, Dessauer, Carmen W., Dascal, Nathan
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.2014)
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Journal Article
Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor
Colombo, Sophie, Reddy, Haritha P, Petri, Sabrina, Williams, Damian J, Shalomov, Boris, Dhindsa, Ryan S, Gelfman, Sahar, Krizay, Daniel, Bera, Amal K, Yang, Mu, Peng, Yueqing, Makinson, Christopher D, Boland, Michael J, Frankel, Wayne N, Goldstein, David B, Dascal, Nathan
Published in Frontiers in cellular neuroscience (18.05.2023)
Published in Frontiers in cellular neuroscience (18.05.2023)
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Journal Article
A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors
Berlin, Shai, Artzy, Etay, Handklo-Jamal, Reem, Kahanovitch, Uri, Parnas, Hanna, Dascal, Nathan, Yakubovich, Daniel
Published in Frontiers in pharmacology (12.08.2020)
Published in Frontiers in pharmacology (12.08.2020)
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Journal Article
GIRK-SPECIFIC DRUGS RESCUE ALTERED CHANNEL ACTIVITY IN GNB1 ENCEPHALOPATHY
Reddy, Haritha, Yakubovitch, Daniel, Raifman, Tal, Pederson, Maria, Shalomov, Boris, Javitch, Jonathan, Bera, Amal, Dascal, Nathan
Published in IBRO neuroscience reports (01.10.2023)
Published in IBRO neuroscience reports (01.10.2023)
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Journal Article
Andersen–Tawil Syndrome Is Associated With Impaired PIP2 Regulation of the Potassium Channel Kir2.1
Handklo-Jamal, Reem, Meisel, Eshcar, Yakubovich, Daniel, Vysochek, Leonid, Beinart, Roy, Glikson, Michael, McMullen, Julie R., Dascal, Nathan, Nof, Eyal, Oz, Shimrit
Published in Frontiers in pharmacology (15.05.2020)
Published in Frontiers in pharmacology (15.05.2020)
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Journal Article
A selectivity filter mutation provides insights into gating regulation of a K + channel
Friesacher, Theres, Reddy, Haritha P, Bernsteiner, Harald, Carlo Combista, J, Shalomov, Boris, Bera, Amal K, Zangerl-Plessl, Eva-Maria, Dascal, Nathan, Stary-Weinzinger, Anna
Published in Communications biology (11.04.2022)
Published in Communications biology (11.04.2022)
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Journal Article
A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ
Yakubovich, Daniel, Berlin, Shai, Kahanovitch, Uri, Rubinstein, Moran, Farhy-Tselnicker, Isabella, Styr, Boaz, Keren-Raifman, Tal, Dessauer, Carmen W, Dascal, Nathan
Published in PLoS computational biology (01.11.2015)
Published in PLoS computational biology (01.11.2015)
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Journal Article
A Novel Mutation in the HCN4 Gene Causes Symptomatic Sinus Bradycardia in Moroccan Jews
LAISH-FARKASH, AVISHAG, GLIKSON, MICHAEL, BRASS, DOVRAT, MAREK-YAGEL, DINA, PRAS, ELON, DASCAL, NATHAN, ANTZELEVITCH, CHARLES, NOF, EYAL, REZNIK, HAYA, ELDAR, MICHAEL, LURIA, DAVID
Published in Journal of cardiovascular electrophysiology (01.12.2010)
Published in Journal of cardiovascular electrophysiology (01.12.2010)
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Journal Article
The M2 Muscarinic G-protein-coupled Receptor Is Voltage-sensitive
Ben-Chaim, Yair, Tour, Oded, Dascal, Nathan, Parnas, Itzchak, Parnas, Hanna
Published in The Journal of biological chemistry (20.06.2003)
Published in The Journal of biological chemistry (20.06.2003)
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Journal Article
Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels
Reddy, Haritha P., Yakubovich, Daniel, Keren-Raifman, Tal, Tabak, Galit, Tsemakhovich, Vladimir A., Pedersen, Maria H., Shalomov, Boris, Colombo, Sophie, Goldstein, David B., Javitch, Jonathan A., Bera, Amal K., Dascal, Nathan
Published in iScience (24.09.2021)
Published in iScience (24.09.2021)
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Journal Article
Competitive and Non-competitive Regulation of Calcium-dependent Inactivation in CaV1.2 L-type Ca2+ Channels by Calmodulin and Ca2+-binding Protein 1
Oz, Shimrit, Benmocha, Adva, Sasson, Yehezkel, Sachyani, Dana, Almagor, Lior, Lee, Amy, Hirsch, Joel A., Dascal, Nathan
Published in The Journal of biological chemistry (03.05.2013)
Published in The Journal of biological chemistry (03.05.2013)
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Journal Article
cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits
Gao, T, Yatani, A, Dell'Acqua, M L, Sako, H, Green, S A, Dascal, N, Scott, J D, Hosey, M M
Published in Neuron (Cambridge, Mass.) (01.07.1997)
Published in Neuron (Cambridge, Mass.) (01.07.1997)
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Journal Article
Anion-sensitive regions of L-type CaV1.2 calcium channels expressed in HEK293 cells
Babai, Norbert, Kanevsky, Nataly, Dascal, Nathan, Rozanski, George J, Singh, Dhirendra P, Fatma, Nigar, Thoreson, Wallace B
Published in PloS one (06.01.2010)
Published in PloS one (06.01.2010)
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