Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations
Jeselsohn, Rinath, Bergholz, Johann S., Pun, Matthew, Cornwell, MacIntosh, Liu, Weihan, Nardone, Agostina, Xiao, Tengfei, Li, Wei, Qiu, Xintao, Buchwalter, Gilles, Feiglin, Ariel, Abell-Hart, Kayley, Fei, Teng, Rao, Prakash, Long, Henry, Kwiatkowski, Nicholas, Zhang, Tinghu, Gray, Nathanael, Melchers, Diane, Houtman, Rene, Liu, X. Shirley, Cohen, Ofir, Wagle, Nikhil, Winer, Eric P., Zhao, Jean, Brown, Myles
Published in Cancer cell (12.02.2018)
Published in Cancer cell (12.02.2018)
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An epigenomic approach to therapy for tamoxifen-resistant breast cancer
Feng, Qin, Zhang, Zheng, Shea, Martin J, Creighton, Chad J, Coarfa, Cristian, Hilsenbeck, Susan G, Lanz, Rainer, He, Bin, Wang, Lei, Fu, Xiaoyong, Nardone, Agostina, Song, Yongcheng, Bradner, James, Mitsiades, Nicholas, Mitsiades, Constantine S, Osborne, C Kent, Schiff, Rachel, O'Malley, Bert W
Published in Cell research (01.07.2014)
Published in Cell research (01.07.2014)
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FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer
Fu, Xiaoyong, Pereira, Resel, De Angelis, Carmine, Veeraraghavan, Jamunarani, Nanda, Sarmistha, Qin, Lanfang, Cataldo, Maria L., Sethunath, Vidyalakshmi, Mehravaran, Sepideh, Gutierrez, Carolina, Chamness, Gary C., Feng, Qin, O’Malley, Bert W., Selenica, Pier, Weigelt, Britta, Reis-Filho, Jorge S., Cohen, Ofir, Wagle, Nikhil, Nardone, Agostina, Jeselsohn, Rinath, Brown, Myles, Rimawi, Mothaffar F., Osborne, C. Kent, Schiff, Rachel
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2019)
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The changing role of ER in endocrine resistance
Nardone, Agostina, De Angelis, Carmine, Trivedi, Meghana V, Osborne, C. Kent, Schiff, Rachel
Published in Breast (Edinburgh) (01.11.2015)
Published in Breast (Edinburgh) (01.11.2015)
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FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer
Fu, Xiaoyong, Jeselsohn, Rinath, Pereira, Resel, Hollingsworth, Emporia F., Creighton, Chad J., Li, Fugen, Shea, Martin, Nardone, Agostina, De Angelis, Carmine, Heiser, Laura M., Anur, Pavana, Wang, Nicholas, Grasso, Catherine S., Spellman, Paul T., Griffith, Obi L., Tsimelzon, Anna, Gutierrez, Carolina, Huang, Shixia, Edwards, Dean P., Trivedi, Meghana V., Rimawi, Mothaffar F., Lopez-Terrada, Dolores, Hilsenbeck, Susan G., Gray, Joe W., Brown, Myles, Osborne, C. Kent, Schiff, Rachel
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2016)
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HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2 + Breast Cancer
Xu, Xiaowei, De Angelis, Carmine, Burke, Kathleen A, Nardone, Agostina, Hu, Huizhong, Qin, Lanfang, Veeraraghavan, Jamunarani, Sethunath, Vidyalakshmi, Heiser, Laura M, Wang, Nicholas, Ng, Charlotte K Y, Chen, Edward S, Renwick, Alexander, Wang, Tao, Nanda, Sarmistha, Shea, Martin, Mitchell, Tamika, Rajendran, Mahitha, Waters, Ian, Zabransky, Daniel J, Scott, Kenneth L, Gutierrez, Carolina, Nagi, Chandandeep, Geyer, Felipe C, Chamness, Gary C, Park, Ben H, Shaw, Chad A, Hilsenbeck, Susan G, Rimawi, Mothaffar F, Gray, Joe W, Weigelt, Britta, Reis-Filho, Jorge S, Osborne, C Kent, Schiff, Rachel
Published in Clinical cancer research (01.09.2017)
Published in Clinical cancer research (01.09.2017)
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Pathway-Centric Integrative Analysis Identifies RRM2 as a Prognostic Marker in Breast Cancer Associated with Poor Survival and Tamoxifen Resistance
Putluri, Nagireddy, Maity, Suman, Kommagani, Ramakrishna, Creighton, Chad J, Putluri, Vasanta, Chen, Fengju, Nanda, Sarmishta, Bhowmik, Salil Kumar, Terunuma, Atsushi, Dorsey, Tiffany, Nardone, Agostina, Fu, Xiaoyong, Shaw, Chad, Sarkar, Tapasree Roy, Schiff, Rachel, Lydon, John P, O’Malley, Bert W, Ambs, Stefan, Das, Gokul M, Michailidis, George, Sreekumar, Arun
Published in Neoplasia (New York, N.Y.) (01.05.2014)
Published in Neoplasia (New York, N.Y.) (01.05.2014)
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High FOXA1 levels induce ER transcriptional reprogramming, a pro-metastatic secretome, and metastasis in endocrine-resistant breast cancer
Fu, Xiaoyong, Pereira, Resel, Liu, Chia-Chia, De Angelis, Carmine, Shea, Martin J., Nanda, Sarmistha, Qin, Lanfang, Mitchell, Tamika, Cataldo, Maria L., Veeraraghavan, Jamunarani, Sethunath, Vidyalakshmi, Giuliano, Mario, Gutierrez, Carolina, Győrffy, Balázs, Trivedi, Meghana V., Cohen, Ofir, Wagle, Nikhil, Nardone, Agostina, Jeselsohn, Rinath, Rimawi, Mothaffar F., Osborne, C. Kent, Schiff, Rachel
Published in Cell reports (Cambridge) (29.08.2023)
Published in Cell reports (Cambridge) (29.08.2023)
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Circulating tumor cell investigation in breast cancer patient-derived xenograft models by automated immunofluorescence staining, image acquisition, and single cell retrieval and analysis
Ramirez, Arturo B, Bhat, Raksha, Sahay, Debashish, De Angelis, Carmine, Thangavel, Hariprasad, Hedayatpour, Sina, Dobrolecki, Lacey E, Nardone, Agostina, Giuliano, Mario, Nagi, Chandandeep, Rimawi, Mothaffar, Osborne, C Kent, Lewis, Michael T, Stilwell, Jackie L, Kaldjian, Eric P, Schiff, Rachel, Trivedi, Meghana V
Published in BMC cancer (12.03.2019)
Published in BMC cancer (12.03.2019)
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Epigenetic Silencing of THY1 Tracks the Acquisition of the Notch1–EGFR Signaling in a Xenograft Model of CD44+/CD24low/CD90+ Myoepithelial Cells
Montanari, Micaela, Carbone, Maria Rita, Coppola, Luigi, Giuliano, Mario, Arpino, Grazia, Lauria, Rossella, Nardone, Agostina, Leccia, Felicia, Trivedi, Meghana V., Garbi, Corrado, Bianco, Roberto, Avvedimento, Enrico V., De Placido, Sabino, Veneziani, Bianca Maria
Published in Molecular cancer research (01.02.2019)
Published in Molecular cancer research (01.02.2019)
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Cytometric and biochemical characterization of human breast cancer cells reveals heterogeneous myoepithelial phenotypes
Leccia, Felicia, Nardone, Agostina, Corvigno, Sara, Vecchio, Luigi Del, De Placido, Sabino, Salvatore, Francesco, Veneziani, Bianca Maria
Published in Cytometry. Part A (01.11.2012)
Published in Cytometry. Part A (01.11.2012)
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Pure estrogen receptor antagonists potentiate capecitabine activity in ESR1-mutant breast cancer
Grinshpun, Albert, Russo, Douglas, Ma, Wen, Verma, Ana, Hermida-Prado, Francisco, Sherman, Shira, Gaglia, Giorgio, Kabraji, Sheheryar, Kirkner, Gregory, Hughes, Melissa E., Lin, Nancy U., Sandusky, Zachary, Nardone, Agostina, Guarducci, Cristina, Nguyen, Quang-De, Santagata, Sandro, Nagy, Zsuzsanna, Jeselsohn, Rinath
Published in NPJ breast cancer (08.06.2024)
Published in NPJ breast cancer (08.06.2024)
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In vitro expansion of human breast cancer epithelial and mesenchymal stromal cells: optimization of a coculture model for personalized therapy approaches
Veneziani, Bianca Maria, Criniti, Vittoria, Cavaliere, Carla, Corvigno, Sara, Nardone, Agostina, Picarelli, Silvia, Tortora, Giampaolo, Ciardiello, Fortunato, Limite, Gennaro, De Placido, Sabino
Published in Molecular cancer therapeutics (01.12.2007)
Published in Molecular cancer therapeutics (01.12.2007)
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Embryonic transcription factor SOX9 drives breast cancer endocrine resistance
Jeselsohn, Rinath, Cornwell, MacIntosh, Pun, Matthew, Buchwalter, Gilles, Nguyen, Mai, Bango, Clyde, Huang, Ying, Kuang, Yanan, Paweletz, Cloud, Fu, Xiaoyong, Nardone, Agostina, De Angelis, Carmine, Detre, Simone, Dodson, Andrew, Mohammed, Hisham, Carroll, Jason S., Bowden, Michaela, Rao, Prakash, Long, Henry W., Li, Fugen, Dowsett, Mitchell, Schiff, Rachel, Brown, Myles
Published in Proceedings of the National Academy of Sciences - PNAS (30.05.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (30.05.2017)
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Journal Article
Abstract B16: Mathematical modeling identifies optimum palbociclib dosing schedules for the treatment of estrogen receptor-positive (ER+) breast cancer patients
Stein, Shayna, Nardone, Agostina, Liu, Weihan, Cohen, Gabriella, Guarducci, Cristina, Brown, Myles, Jeselsohn, Rinath, Michor, Franziska
Published in Cancer research (Chicago, Ill.) (01.06.2020)
Published in Cancer research (Chicago, Ill.) (01.06.2020)
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Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer
De Angelis, Carmine, Fu, Xiaoyong, Cataldo, Maria Letizia, Nardone, Agostina, Pereira, Resel, Veeraraghavan, Jamunarani, Nanda, Sarmistha, Qin, Lanfang, Sethunath, Vidyalakshmi, Wang, Tao, Hilsenbeck, Susan G, Benelli, Matteo, Migliaccio, Ilenia, Guarducci, Cristina, Malorni, Luca, Litchfield, Lacey M, Liu, Jiangang, Donaldson, Joshua, Selenica, Pier, Brown, David N, Weigelt, Britta, Reis-Filho, Jorge S, Park, Ben H, Hurvitz, Sara A, Slamon, Dennis J, Rimawi, Mothaffar F, Jansen, Valerie M, Jeselsohn, Rinath, Osborne, C Kent, Schiff, Rachel
Published in Clinical cancer research (01.09.2021)
Published in Clinical cancer research (01.09.2021)
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The oral selective oestrogen receptor degrader (SERD) AZD9496 is comparable to fulvestrant in antagonising ER and circumventing endocrine resistance
Nardone, Agostina, Weir, Hazel, Delpuech, Oona, Brown, Henry, De Angelis, Carmine, Cataldo, Maria Letizia, Fu, Xiaoyong, Shea, Martin J., Mitchell, Tamika, Veeraraghavan, Jamunarani, Nagi, Chandandeep, Pilling, Mark, Rimawi, Mothaffar F., Trivedi, Meghana, Hilsenbeck, Susan G., Chamness, Gary C., Jeselsohn, Rinath, Osborne, C. Kent, Schiff, Rachel
Published in British journal of cancer (05.02.2019)
Published in British journal of cancer (05.02.2019)
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Journal Article
Clinical Efficacy and Whole-Exome Sequencing of Liquid Biopsies in a Phase IB/II Study of Bazedoxifene and Palbociclib in Advanced Hormone Receptor-Positive Breast Cancer
Tsuji, Junko, Li, Tianyu, Grinshpun, Albert, Coorens, Tim, Russo, Douglas, Anderson, Leilani, Rees, Rebecca, Nardone, Agostina, Patterson, Candace, Lennon, Niall J, Cibulskis, Carrie, Leshchiner, Ignaty, Tayob, Nabihah, Tolaney, Sara M, Tung, Nadine, McDonnell, Donald P, Krop, Ian E, Winer, Eric P, Stewart, Chip, Getz, Gad, Jeselsohn, Rinath
Published in Clinical cancer research (01.12.2022)
Published in Clinical cancer research (01.12.2022)
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Journal Article
Abstract PD8-03: A FOXA1/FRA1-centered transcriptional axis regulates interferon signaling in high FOXA1-associated endocrine-resistant and metastatic breast cancer
Fu, Xiaoyong, Pereira, Resel, Qin, Lanfang, De Angelis, Carmine, Nanda, Sarmistha, Shea, Martin, Nardone, Agostina, Jeselsohn, Rinath, Cohen, Ofir, Wagle, Nikhil, Rimawi, Mothaffar, Osborne, C Kent, Schiff, Rachel
Published in Cancer research (Chicago, Ill.) (15.02.2021)
Published in Cancer research (Chicago, Ill.) (15.02.2021)
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