12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat
Leiria, Luiz Osório, Wang, Chih-Hao, Lynes, Matthew D., Yang, Kunyan, Shamsi, Farnaz, Sato, Mari, Sugimoto, Satoru, Chen, Emily Y., Bussberg, Valerie, Narain, Niven R., Sansbury, Brian E., Darcy, Justin, Huang, Tian Lian, Kodani, Sean D., Sakaguchi, Masaji, Rocha, Andréa L., Schulz, Tim J., Bartelt, Alexander, Hotamisligil, Gökhan S., Hirshman, Michael F., van Leyen, Klaus, Goodyear, Laurie J., Blüher, Matthias, Cypess, Aaron M., Kiebish, Michael A., Spite, Matthew, Tseng, Yu-Hua
Published in Cell metabolism (01.10.2019)
Published in Cell metabolism (01.10.2019)
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CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice
Wang, Chih-Hao, Lundh, Morten, Fu, Accalia, Kriszt, Rókus, Huang, Tian Lian, Lynes, Matthew D, Leiria, Luiz O, Shamsi, Farnaz, Darcy, Justin, Greenwood, Bennett P, Narain, Niven R, Tolstikov, Vladimir, Smith, Kyle L, Emanuelli, Brice, Chang, Young-Tae, Hagen, Susan, Danial, Nika N, Kiebish, Michael A, Tseng, Yu-Hua
Published in Science translational medicine (26.08.2020)
Published in Science translational medicine (26.08.2020)
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Journal Article
High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources
Haraszti, Reka A., Didiot, Marie-Cecile, Sapp, Ellen, Leszyk, John, Shaffer, Scott A., Rockwell, Hannah E., Gao, Fei, Narain, Niven R., DiFiglia, Marian, Kiebish, Michael A., Aronin, Neil, Khvorova, Anastasia
Published in Journal of extracellular vesicles (01.01.2016)
Published in Journal of extracellular vesicles (01.01.2016)
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Prophylactic ketamine alters nucleotide and neurotransmitter metabolism in brain and plasma following stress
McGowan, Josephine C, Hill, Collin, Mastrodonato, Alessia, LaGamma, Christina T, Kitayev, Alexander, Brachman, Rebecca A, Narain, Niven R, Kiebish, Michael A, Denny, Christine A
Published in Neuropsychopharmacology (New York, N.Y.) (01.08.2018)
Published in Neuropsychopharmacology (New York, N.Y.) (01.08.2018)
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Journal Article
Light-responsive adipose-hypothalamus axis controls metabolic regulation
Tsuji, Tadataka, Tolstikov, Vladimir, Zhang, Yang, Huang, Tian Lian, Camara, Henrique, Halpin, Meghan, Narain, Niven R., Yau, King-Wai, Lynes, Matthew D., Kiebish, Michael A., Tseng, Yu-Hua
Published in Nature communications (08.08.2024)
Published in Nature communications (08.08.2024)
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The Next Frontier: Translational Development of Ubiquitination, SUMOylation, and NEDDylation in Cancer
Pellegrino, Nicole E, Guven, Arcan, Gray, Kayleigh, Shah, Punit, Kasture, Gargi, Nastke, Maria-Dorothea, Thakurta, Anjan, Gesta, Stephane, Vishnudas, Vivek K, Narain, Niven R, Kiebish, Michael A
Published in International journal of molecular sciences (23.03.2022)
Published in International journal of molecular sciences (23.03.2022)
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Journal Article
Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism
Lynes, Matthew D., Shamsi, Farnaz, Sustarsic, Elahu Gosney, Leiria, Luiz O., Wang, Chih-Hao, Su, Sheng-Chiang, Huang, Tian Lian, Gao, Fei, Narain, Niven R., Chen, Emily Y., Cypess, Aaron M., Schulz, Tim J., Gerhart-Hines, Zachary, Kiebish, Michael A., Tseng, Yu-Hua
Published in Cell reports (Cambridge) (17.07.2018)
Published in Cell reports (Cambridge) (17.07.2018)
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Journal Article
Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
Schlein, Christian, Fischer, Alexander W., Sass, Frederike, Worthmann, Anna, Tödter, Klaus, Jaeckstein, Michelle Y., Behrens, Janina, Lynes, Matthew D., Kiebish, Michael A., Narain, Niven R., Bussberg, Val, Darkwah, Abena, Jespersen, Naja Zenius, Nielsen, Søren, Scheele, Camilla, Schweizer, Michaela, Braren, Ingke, Bartelt, Alexander, Tseng, Yu-Hua, Heeren, Joerg, Scheja, Ludger
Published in Cell reports (Cambridge) (12.01.2021)
Published in Cell reports (Cambridge) (12.01.2021)
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Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer
Kiebish, Michael A, Cullen, Jennifer, Mishra, Prachi, Ali, Amina, Milliman, Eric, Rodrigues, Leonardo O, Chen, Emily Y, Tolstikov, Vladimir, Zhang, Lixia, Panagopoulos, Kiki, Shah, Punit, Chen, Yongmei, Petrovics, Gyorgy, Rosner, Inger L, Sesterhenn, Isabell A, McLeod, David G, Granger, Elder, Sarangarajan, Rangaprasad, Akmaev, Viatcheslav, Srinivasan, Alagarsamy, Srivastava, Shiv, Narain, Niven R, Dobi, Albert
Published in Journal of translational medicine (07.01.2020)
Published in Journal of translational medicine (07.01.2020)
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Reduced expression of collagen VI alpha 3 (COL6A3) confers resistance to inflammation‐induced MCP1 expression in adipocytes
Gesta, Stephane, Guntur, Kalyani, Majumdar, Ishita Deb, Akella, Syamala, Vishnudas, Vivek K., Sarangarajan, Rangaprasad, Narain, Niven R.
Published in Obesity (Silver Spring, Md.) (01.08.2016)
Published in Obesity (Silver Spring, Md.) (01.08.2016)
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Identification and validation of N-acetylputrescine in combination with non-canonical clinical features as a Parkinson’s disease biomarker panel
Peng, Kuan-Wei, Klotz, Allison, Guven, Arcan, Kapadnis, Unnati, Ravipaty, Shobha, Tolstikov, Vladimir, Vemulapalli, Vijetha, Rodrigues, Leonardo O., Li, Hongyan, Kellogg, Mark D., Kausar, Farah, Rees, Linda, Sarangarajan, Rangaprasad, Schüle, Birgitt, Langston, William, Narain, Paula, Narain, Niven R., Kiebish, Michael A.
Published in Scientific reports (02.05.2024)
Published in Scientific reports (02.05.2024)
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Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling
May, Francis J., Baer, Lisa A., Lehnig, Adam C., So, Kawai, Chen, Emily Y., Gao, Fei, Narain, Niven R., Gushchina, Liubov, Rose, Aubrey, Doseff, Andrea I., Kiebish, Michael A., Goodyear, Laurie J., Stanford, Kristin I.
Published in Cell reports (Cambridge) (07.02.2017)
Published in Cell reports (Cambridge) (07.02.2017)
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Journal Article
Transplantation of Brown Adipose Tissue with the Ability of Converting Omega-6 to Omega-3 Polyunsaturated Fatty Acids Counteracts High-Fat-Induced Metabolic Abnormalities in Mice
Tsuji, Tadataka, Bussberg, Valerie, MacDonald, Allison M, Narain, Niven R, Kiebish, Michael A, Tseng, Yu-Hua
Published in International journal of molecular sciences (10.05.2022)
Published in International journal of molecular sciences (10.05.2022)
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Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma
Mukherjee, Purna, Augur, Zachary M., Li, Mingyi, Hill, Collin, Greenwood, Bennett, Domin, Marek A., Kondakci, Gramoz, Narain, Niven R., Kiebish, Michael A., Bronson, Roderick T., Arismendi-Morillo, Gabriel, Chinopoulos, Christos, Seyfried, Thomas N.
Published in Communications biology (29.05.2019)
Published in Communications biology (29.05.2019)
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Residual Complex I activity and amphidirectional Complex II operation support glutamate catabolism through mtSLP in anoxia
Ravasz, Dora, Bui, David, Nazarian, Sara, Pallag, Gergely, Karnok, Noemi, Roberts, Jennie, Marzullo, Bryan P., Tennant, Daniel A., Greenwood, Bennett, Kitayev, Alex, Hill, Collin, Komlódi, Timea, Doerrier, Carolina, Cunatova, Kristyna, Fernandez-Vizarra, Erika, Gnaiger, Erich, Kiebish, Michael A., Raska, Alexandra, Kolev, Krasimir, Czumbel, Bence, Narain, Niven R., Seyfried, Thomas N., Chinopoulos, Christos
Published in Scientific reports (19.01.2024)
Published in Scientific reports (19.01.2024)
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Elevated levels of mitochondrial CoQ10 induce ROS-mediated apoptosis in pancreatic cancer
Dadali, Tulin, Diers, Anne R., Kazerounian, Shiva, Muthuswamy, Senthil K., Awate, Pallavi, Ng, Ryan, Mogre, Saie, Spencer, Carrie, Krumova, Katerina, Rockwell, Hannah E., McDaniel, Justice, Chen, Emily Y., Gao, Fei, Diedrich, Karl T., Vemulapalli, Vijetha, Rodrigues, Leonardo O., Akmaev, Viatcheslav R., Thapa, Khampaseuth, Hidalgo, Manuel, Bose, Arindam, Vishnudas, Vivek K., Moser, A. James, Granger, Elder, Kiebish, Michael A., Gesta, Stephane, Narain, Niven R., Sarangarajan, Rangaprasad
Published in Scientific reports (11.03.2021)
Published in Scientific reports (11.03.2021)
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Journal Article
Impact of hemolysis on multi-OMIC pancreatic biomarker discovery to derisk biomarker development in precision medicine studies
Searfoss, Richard, Shah, Punit, Ofori-Mensa, Kennedy, Bussberg, Valerie, Tolstikov, Vladimir, Greenwood, Bennett, Li, Hongyan, Richardson, Kris, Miller, Gregory M., DeCicco, Corinne, Granger, Elder, Rodrigues, Leonardo O., Grund, Eric M., Moser, A. James, Sarangarajan, Rangaprasad, Narain, Niven R., Kiebish, Michael A.
Published in Scientific reports (24.01.2022)
Published in Scientific reports (24.01.2022)
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High levels of ubidecarenone (oxidized CoQ10) delivered using a drug-lipid conjugate nanodispersion (BPM31510) differentially affect redox status and growth in malignant glioma versus non-tumor cells
Sun, Jiaxin, Patel, Chirag B., Jang, Taichang, Merchant, Milton, Chen, Chen, Kazerounian, Shiva, Diers, Anne R., Kiebish, Michael A., Vishnudas, Vivek K., Gesta, Stephane, Sarangarajan, Rangaprasad, Narain, Niven R., Nagpal, Seema, Recht, Lawrence
Published in Scientific reports (17.08.2020)
Published in Scientific reports (17.08.2020)
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Journal Article
Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition
Haraszti, Reka Agnes, Miller, Rachael, Dubuke, Michelle L, Rockwell, Hannah E, Coles, Andrew H, Sapp, Ellen, Didiot, Marie-Cecile, Echeverria, Dimas, Stoppato, Matteo, Sere, Yves Y, Leszyk, John, Alterman, Julia F, Godinho, Bruno M D C, Hassler, Matthew R, McDaniel, Justice, Narain, Niven R, Wollacott, Rachel, Wang, Yang, Shaffer, Scott A, Kiebish, Michael A, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Published in iScience (28.06.2019)
Published in iScience (28.06.2019)
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