Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter
Niu, Yange, Liu, Rui, Guan, Chengcheng, Zhang, Yuan, Chen, Zhixing, Hoerer, Stefan, Nar, Herbert, Chen, Lei
Published in Nature (London) (13.01.2022)
Published in Nature (London) (13.01.2022)
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Journal Article
A specific antidote for dabigatran: functional and structural characterization
Schiele, Felix, van Ryn, Joanne, Canada, Keith, Newsome, Corey, Sepulveda, Eliud, Park, John, Nar, Herbert, Litzenburger, Tobias
Published in Blood (02.05.2013)
Published in Blood (02.05.2013)
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Journal Article
Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
Martin, Laetitia J, Koegl, Manfred, Bader, Gerd, Cockcroft, Xiao-Ling, Fedorov, Oleg, Fiegen, Dennis, Gerstberger, Thomas, Hofmann, Marco H, Hohmann, Anja F, Kessler, Dirk, Knapp, Stefan, Knesl, Petr, Kornigg, Stefan, Müller, Susanne, Nar, Herbert, Rogers, Catherine, Rumpel, Klaus, Schaaf, Otmar, Steurer, Steffen, Tallant, Cynthia, Vakoc, Christopher R, Zeeb, Markus, Zoephel, Andreas, Pearson, Mark, Boehmelt, Guido, McConnell, Darryl
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Journal Article
Crystal structure and receptor-interacting residues of MYDGF - a protein mediating ischemic tissue repair
Ebenhoch, Rebecca, Akhdar, Abbas, Reboll, Marc R, Korf-Klingebiel, Mortimer, Gupta, Priyanka, Armstrong, Julie, Huang, Yining, Frego, Lee, Rybina, Irina, Miglietta, John, Pekcec, Anton, Wollert, Kai C, Nar, Herbert
Published in Nature communications (26.11.2019)
Published in Nature communications (26.11.2019)
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Journal Article
An Antibody against the C-Terminal Domain of PCSK9 Lowers LDL Cholesterol Levels In Vivo
Schiele, Felix, Park, John, Redemann, Norbert, Luippold, Gerd, Nar, Herbert
Published in Journal of molecular biology (20.02.2014)
Published in Journal of molecular biology (20.02.2014)
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Journal Article
A Single Second Shell Amino Acid Determines Affinity and Kinetics of Linagliptin Binding to Type 4 Dipeptidyl Peptidase and Fibroblast Activation Protein
Schnapp, Gisela, Hoevels, Yvette, Bakker, Remko A., Schreiner, Patrick, Klein, Thomas, Nar, Herbert
Published in ChemMedChem (17.02.2021)
Published in ChemMedChem (17.02.2021)
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Journal Article
Protons taken hostage: Dynamic H-bond networks of the pH-sensing GPR68
Kapur, Bhav, Baldessari, Filippo, Lazaratos, Michalis, Nar, Herbert, Schnapp, Gisela, Giorgetti, Alejandro, Bondar, Ana-Nicoleta
Published in Computational and structural biotechnology journal (01.01.2023)
Published in Computational and structural biotechnology journal (01.01.2023)
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Journal Article
Structure-Based Design of Novel Potent Nonpeptide Thrombin Inhibitors
Hauel, Norbert H, Nar, Herbert, Priepke, Henning, Ries, Uwe, Stassen, Jean-Marie, Wienen, Wolfgang
Published in Journal of medicinal chemistry (25.04.2002)
Published in Journal of medicinal chemistry (25.04.2002)
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Journal Article
Structural Basis for Photo-induced Protein Cleavage and Green-to-Red Conversion of Fluorescent Protein EosFP
Nienhaus, Karin, Nienhaus, G. Ulrich, Wiedenmann, Jörg, Nar, Herbert, Wolynes, Peter G.
Published in Proceedings of the National Academy of Sciences - PNAS (28.06.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (28.06.2005)
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Journal Article
In silico enzyme screening identifies an SDR ketoreductase from Thermus caliditerrae as an attractive biocatalyst and promising candidate for protein engineering
Sosa, Yvett, Kapur, Bhav, Hurtak, Jessica, Kingsley, Laura J., Wu, Hao, Gruber, Stefanie, Nar, Herbert, Khattabi, Saad, Moral, Jesus Seco, Lucas, Maria Fátima, Martin, Caterina, Lončar, Nikola, Buono, Frederic, Pefaur, Noah, Nixon, Andrew E., Song, Jinhua J.
Published in Frontiers in Chemical Biology (23.07.2024)
Published in Frontiers in Chemical Biology (23.07.2024)
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Journal Article
A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state
Schnapp, Gisela, Neubauer, Heike, Büttner, Frank H, Handschuh, Sandra, Lingard, Iain, Heilker, Ralf, Klinder, Klaus, Prestle, Jürgen, Walter, Rainer, Wolff, Michael, Zeeb, Markus, Debaene, Francois, Nar, Herbert, Fiegen, Dennis
Published in Communications chemistry (10.06.2020)
Published in Communications chemistry (10.06.2020)
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Journal Article
Photoconvertible Fluorescent Protein EosFP: Biophysical Properties and Cell Biology Applications
Nienhaus, G. Ulrich, Nienhaus, Karin, Hölzle, Angela, Ivanchenko, Sergey, Renzi, Fabiana, Oswald, Franz, Wolff, Michael, Schmitt, Florian, Röcker, Carlheinz, Vallone, Beatrice, Weidemann, Wolfgang, Heilker, Ralf, Nar, Herbert, Wiedenmann, Jörg
Published in Photochemistry and photobiology (01.03.2006)
Published in Photochemistry and photobiology (01.03.2006)
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Journal Article
Development and Characterization of a Cocrystal as a Viable Solid Form for an Active Pharmaceutical Ingredient
Kim, Soojin, Li, Zhibin, Tseng, Yin-Chao, Nar, Herbert, Spinelli, Earl, Varsolona, Richard, Reeves, Jonathan T, Lee, Heewon, Song, Jinhua J, Smoliga, John, Yee, Nathan, Senanayake, Chris
Published in Organic process research & development (15.03.2013)
Published in Organic process research & development (15.03.2013)
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Journal Article
Zinc Plays a Key Role in Human and Bacterial GTP Cyclohydrolase I
Auerbach, G, Herrmann, A, Bracher, A, Bader, G, Gutlich, M, Fischer, M, Neukamm, M, Garrido-Franco, M, Richardson, J, Nar, H, Huber, R, Bacher, A
Published in Proceedings of the National Academy of Sciences - PNAS (05.12.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (05.12.2000)
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Journal Article
Heterocyclic thrombin inhibitors. Part 2: quinoxalinone derivatives as novel, potent antithrombotic agents
Ries, Uwe J., Priepke, Henning W.M., Hauel, Norbert H., Handschuh, Sandra, Mihm, Gerhard, Stassen, Jean M., Wienen, Wolfgang, Nar, Herbert
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
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Journal Article
Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation
Nar, Herbert, Bauer, Margit, Stassen, Jean-Marie, Lang, Dietmar, Gils, Ann, Declerck, Paul J
Published in Journal of molecular biology (31.03.2000)
Published in Journal of molecular biology (31.03.2000)
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Journal Article
Structural Characterization of Three Crystalline Modifications of Telmisartan by Single Crystal and High‐Resolution X‐ray Powder Diffraction
Dinnebier, Robert E., Sieger, Peter, Nar, Herbert, Shankland, Kenneth, David, William I.F.
Published in Journal of pharmaceutical sciences (01.11.2000)
Published in Journal of pharmaceutical sciences (01.11.2000)
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Journal Article
Biophysics in drug discovery: impact, challenges and opportunities
Renaud, Jean-Paul, Chung, Chun-Wa, Danielson, U Helena, Egner, Ursula, Hennig, Michael, Hubbard, Roderick E, Nar, Herbert
Published in Nature reviews. Drug discovery (01.10.2016)
Published in Nature reviews. Drug discovery (01.10.2016)
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Journal Article
Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis
Rübbelke, Martin, Fiegen, Dennis, Bauer, Margit, Binder, Florian, Hamilton, James, King, Jim, Thamm, Sven, Nar, Herbert, Zeeb, Markus
Published in Proceedings of the National Academy of Sciences - PNAS (29.12.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (29.12.2020)
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Journal Article