Maraviroc (UK-427,857), a Potent, Orally Bioavailable, and Selective Small-Molecule Inhibitor of Chemokine Receptor CCR5 with Broad-Spectrum Anti-Human Immunodeficiency Virus Type 1 Activity
DORR, Patrick, WESTBY, Mike, WEBSTER, Rob, ARMOUR, Duncan, PRICE, David, STAMMEN, Blanda, WOOD, Anthony, PERROS, Manos, DOBBS, Susan, GRIFFIN, Paul, IRVINE, Becky, MACARTNEY, Malcolm, MORI, Julie, RICKETT, Graham, SMITH-BURCHNELL, Caroline, NAPIER, Carolyn
Published in Antimicrobial Agents and Chemotherapy (01.11.2005)
Published in Antimicrobial Agents and Chemotherapy (01.11.2005)
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Functional Selectivity of Muscarinic Receptor Antagonists for Inhibition of M3-Mediated Phosphoinositide Responses in Guinea Pig Urinary Bladder and Submandibular Salivary Gland
Nelson, Carl P, Gupta, Paul, Napier, Carolyn M, Nahorski, Stefan R, Challiss, R A John
Published in The Journal of pharmacology and experimental therapeutics (01.09.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2004)
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Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma
Millan, David S., Ballard, Stephen A., Chunn, Sara, Dybowski, Joseph A., Fulton, Craig K., Glossop, Paul A., Guillabert, Edouard, Hewson, Christopher A., Jones, Rhys M., Lamb, David J., Napier, Carolyn M., Payne-Cook, Toby A., Renery, Emmanuelle R., Selby, Matthew D., Tutt, Michelle F., Yeadon, Michael
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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Design and synthesis of a fluorescent muscarinic antagonist
Jones, Lyn H., Randall, Amy, Napier, Carolyn, Trevethick, Mike, Sreckovic, Sasha, Watson, Jessica
Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
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Overcoming hERG affinity in the discovery of maraviroc; a CCR5 antagonist for the treatment of HIV
Price, David A, Armour, Duncan, de Groot, Marcel, Leishman, Derek, Napier, Carolyn, Perros, Manos, Stammen, Blanda L, Wood, Anthony
Published in Current topics in medicinal chemistry (01.09.2008)
Published in Current topics in medicinal chemistry (01.09.2008)
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The Napiergram: A tool for visualising efficacy and safety data
Napier, Carolyn, Wallis, Robert
Published in Journal of pharmacological and toxicological methods (01.09.2010)
Published in Journal of pharmacological and toxicological methods (01.09.2010)
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Journal Article
Overcoming HERG affinity in the discovery of the CCR5 antagonist maraviroc
Price, David A., Armour, Duncan, de Groot, Marcel, Leishman, Derek, Napier, Carolyn, Perros, Manos, Stammen, Blanda L., Wood, Anthony
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human
Napier, Carolyn, Sale, Harriet, Mosley, Michael, Rickett, Graham, Dorr, Pat, Mansfield, Roy, Holbrook, Mark
Published in Biochemical pharmacology (19.12.2005)
Published in Biochemical pharmacology (19.12.2005)
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Journal Article
Functional Selectivity of Muscarinic Receptor Antagonists for Inhibition of M 3 -Mediated Phosphoinositide Responses in Guinea Pig Urinary Bladder and Submandibular Salivary Gland
Nelson, Carl P., Gupta, Paul, Napier, Carolyn M., Nahorski, Stefan R., Challiss, R. A. John
Published in The Journal of pharmacology and experimental therapeutics (01.09.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2004)
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Estimation of binding rate constants using a simultaneous mixed‐effects method: application to monoamine transporter reuptake inhibitor reboxetine
Benson, Neil, Snelder, Nelleke, Ploeger, Bart, Napier, Carolyn, Sale, Harriet, JM Birdsall, Nigel, Butt, Richard P, van der Graaf, Piet H
Published in British journal of pharmacology (01.05.2010)
Published in British journal of pharmacology (01.05.2010)
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Localisation of melanin-concentrating hormone receptor 1 in rat brain and evidence that sleep parameters are not altered despite high central receptor occupancy
Able, Sarah L., Ivarsson, Magnus, Fish, Rebecca L., Clarke, Tracey L., McCourt, Clare, Duckworth, Jonathan M., Napier, Carolyn, Katugampola, Sidath D.
Published in European journal of pharmacology (15.08.2009)
Published in European journal of pharmacology (15.08.2009)
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Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors
NAPIER, C, STEWART, M, MELROSE, H, HOPKINS, B, MCHARG, A, WALLIS, R
Published in European journal of pharmacology (05.03.1999)
Published in European journal of pharmacology (05.03.1999)
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The molecular cloning and functional expression of the dog CCR5
Mosley, Michael, Pullen, Sarah, Botham, Andrew, Gray, Andrew, Napier, Carolyn, Mansfield, Roy, Holbrook, Mark
Published in Veterinary Immunology and Immunopathology (15.10.2006)
Published in Veterinary Immunology and Immunopathology (15.10.2006)
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CCR5 pharmacology methodologies and associated applications
Mansfield, Roy, Able, Sarah, Griffin, Paul, Irvine, Becky, James, Ian, Macartney, Malcolm, Miller, Ken, Mills, James, Napier, Carolyn, Navratilova, Iva, Perros, Manos, Rickett, Graham, Root, Harriet, van der Ryst, Elna, Westby, Mike, Dorr, Patrick
Published in Methods in enzymology (2009)
Published in Methods in enzymology (2009)
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Characterisation of the contractile activity of eletriptan at the canine vascular 5-HT1B receptor
GUPTA, P, SCATCHARD, J, NAPIER, C, MCHARG, A, WALLIS, R
Published in European journal of pharmacology (19.02.1999)
Published in European journal of pharmacology (19.02.1999)
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