Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding
Que, Nanette L. S, Crowley, Vincent M, Duerfeldt, Adam S, Zhao, Jinbo, Kent, Caitlin N, Blagg, Brian S. J, Gewirth, Daniel T
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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Journal Article
Exploring the Functional Complementation between Grp94 and Hsp90
Maharaj, Kevin A, Que, Nanette L S, Hong, Feng, Huck, John D, Gill, Sabrina K, Wu, Shuang, Li, Zihai, Gewirth, Daniel T
Published in PloS one (08.11.2016)
Published in PloS one (08.11.2016)
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Journal Article
NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90
Huck, John D., Que, Nanette L.S., Immormino, Robert M., Shrestha, Liza, Taldone, Tony, Chiosis, Gabriela, Gewirth, Daniel T.
Published in The Journal of biological chemistry (01.11.2019)
Published in The Journal of biological chemistry (01.11.2019)
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Journal Article
Structures of Hsp90α and Hsp90β bound to a purine‐scaffold inhibitor reveal an exploitable residue for drug selectivity
Huck, John D., Que, Nanette L. S., Sharma, Sahil, Taldone, Tony, Chiosis, Gabriela, Gewirth, Daniel T.
Published in Proteins, structure, function, and bioinformatics (01.10.2019)
Published in Proteins, structure, function, and bioinformatics (01.10.2019)
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Journal Article
Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone
Yan, Pengrong, Patel, Hardik J., Sharma, Sahil, Corben, Adriana, Wang, Tai, Panchal, Palak, Yang, Chenghua, Sun, Weilin, Araujo, Thais L., Rodina, Anna, Joshi, Suhasini, Robzyk, Kenneth, Gandu, Srinivasa, White, Julie R., de Stanchina, Elisa, Modi, Shanu, Janjigian, Yelena Y., Hill, Elizabeth G., Liu, Bei, Erdjument-Bromage, Hediye, Neubert, Thomas A., Que, Nanette L.S., Li, Zihai, Gewirth, Daniel T., Taldone, Tony, Chiosis, Gabriela
Published in Cell reports (Cambridge) (30.06.2020)
Published in Cell reports (Cambridge) (30.06.2020)
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Journal Article
A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2
Que-Gewirth, Nanette L S, Ribeiro, Anthony A, Kalb, Suzanne R, Cotter, Robert J, Bulach, Dieter M, Adler, Ben, Girons, Isabelle Saint, Werts, Catherine, Raetz, Christian R H
Published in The Journal of biological chemistry (11.06.2004)
Published in The Journal of biological chemistry (11.06.2004)
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Journal Article
Expression, Purification, and Characterization of TylB, an Aminotransferase Involved in the Biosynthesis of Mycaminose
Chen, Huawei, Yeung, Siu-Man, Que, Nanette L. S, Müller, Thomas, Schmidt, Richard R, Liu, Hung-wen
Published in Journal of the American Chemical Society (04.08.1999)
Published in Journal of the American Chemical Society (04.08.1999)
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Journal Article
Origin of the 2-amino-2-deoxy-gluconate unit in Rhizobium leguminosarum lipid A. Expression cloning of the outer membrane oxidase LpxQ
Que-Gewirth, Nanette L S, Karbarz, Mark J, Kalb, Suzanne R, Cotter, Robert J, Raetz, Christian R H
Published in The Journal of biological chemistry (04.04.2003)
Published in The Journal of biological chemistry (04.04.2003)
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Journal Article
Selective inhibition of hsp90 paralogs: Uncovering the role of helix 1 in Grp94-selective ligand binding
Que, Nanette L S, Seidler, Paul M, Aw, Wen J, Chiosis, Gabriela, Gewirth, Daniel T
Published in bioRxiv (19.08.2024)
Published in bioRxiv (19.08.2024)
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Journal Article
Purification and mass spectrometry of six lipid A species from the bacterial endosymbiont Rhizobium etli. Demonstration of a conserved distal unit and a variable proximal portion
Que, N L, Lin, S, Cotter, R J, Raetz, C R
Published in The Journal of biological chemistry (08.09.2000)
Published in The Journal of biological chemistry (08.09.2000)
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Journal Article
A deacylase in Rhizobium leguminosarum membranes that cleaves the 3-O-linked beta-hydroxymyristoyl moiety of lipid a precursors
Basu, S.S. (Duke University Medical Center, Durham, NC.), White, K.A, Que, N.L.S, Raetz, C.R.H
Published in The Journal of biological chemistry (16.04.1999)
Published in The Journal of biological chemistry (16.04.1999)
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Journal Article
Two-dimensional NMR Spectroscopy and Structures of Six Lipid A Species from Rhizobium etli CE3 DETECTION OF AN ACYLOXYACYL RESIDUE IN EACH COMPONENT AND ORIGIN OF THE AMINOGLUCONATE MOIETYS
Que, Nanette L. S., Ribeiro, Anthony A., Raetz, Christian R. H.
Published in The Journal of biological chemistry (08.09.2000)
Published in The Journal of biological chemistry (08.09.2000)
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Journal Article
A Methylated Phosphate Group and Four Amide-linked Acyl Chains in Leptospira interrogans Lipid A
Que-Gewirth, Nanette L.S., Ribeiro, Anthony A., Kalb, Suzanne R., Cotter, Robert J., Bulach, Dieter M., Adler, Ben, Girons, Isabelle Saint, Werts, Catherine, Raetz, Christian R.H.
Published in The Journal of biological chemistry (11.06.2004)
Published in The Journal of biological chemistry (11.06.2004)
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Journal Article