Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550)
Ghoreschi, Kamran, Jesson, Michael I, Li, Xiong, Lee, Jamie L, Ghosh, Sarbani, Alsup, Jason W, Warner, James D, Tanaka, Masao, Steward-Tharp, Scott M, Gadina, Massimo, Thomas, Craig J, Minnerly, John C, Storer, Chad E, LaBranche, Timothy P, Radi, Zaher A, Dowty, Martin E, Head, Richard D, Meyer, Debra M, Kishore, Nandini, O'Shea, John J
Published in The Journal of immunology (1950) (01.04.2011)
Published in The Journal of immunology (1950) (01.04.2011)
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Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis
Meyer, Debra M, Jesson, Michael I, Li, Xiong, Elrick, Mollisa M, Funckes-Shippy, Christie L, Warner, James D, Gross, Cindy J, Dowty, Martin E, Ramaiah, Shashi K, Hirsch, Jeffrey L, Saabye, Matthew J, Barks, Jennifer L, Kishore, Nandini, Morris, Dale L
Published in Journal of inflammation (London, England) (11.08.2010)
Published in Journal of inflammation (London, England) (11.08.2010)
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Therapeutic targeting of Janus kinases
Pesu, Marko, Laurence, Arian, Kishore, Nandini, Zwillich, Samuel H., Chan, Gary, O'Shea, John J.
Published in Immunological reviews (01.06.2008)
Published in Immunological reviews (01.06.2008)
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Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure–activity relationship
Xie, Jin, Poda, Gennadiy I., Hu, Yiding, Chen, Natalie X., Heier, Richard F., Wolfson, Serge G., Reding, Matthew T., Lennon, Patrick J., Kurumbail, Ravi G., Selness, Shaun R., Li, Xiong, Kishore, Nandini N., Sommers, Cynthia D., Christine, Lori, Bonar, Sheri L., Venkatraman, Neetu, Mathialagan, Sumathy, Brustkern, Sarah J., Huang, Horng-Chih
Published in Bioorganic & medicinal chemistry (01.02.2011)
Published in Bioorganic & medicinal chemistry (01.02.2011)
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Inhibition of IKK-2 by 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides
Bonafoux, Dominique, Bonar, Sheri, Christine, Lori, Clare, Michael, Donnelly, Ann, Guzova, Julia, Kishore, Nandini, Lennon, Patrick, Libby, Adam, Mathialagan, Sumathy, McGhee, William, Rouw, Sharon, Sommers, Cindy, Tollefson, Michael, Tripp, Catherine, Weier, Richard, Wolfson, Serge, Min, Yao
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
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Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis
Dowty, Martin E, Jesson, Michael I, Ghosh, Sarbani, Lee, Jamie, Meyer, Debra M, Krishnaswami, Sriram, Kishore, Nandini
Published in The Journal of pharmacology and experimental therapeutics (01.01.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2014)
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Novel Biologically Active Nonpeptidic Inhibitors of MyristoylCoA:Protein N-Myristoyltransferase
Devadas, Balekudru, Freeman, Sandra K, McWherter, Charles A, Kishore, Nandini S, Lodge, Jennifer K, Jackson-Machelski, Emily, Gordon, Jeffrey I, Sikorski, James A
Published in Journal of medicinal chemistry (12.03.1998)
Published in Journal of medicinal chemistry (12.03.1998)
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Design and Synthesis of Novel Imidazole-Substituted Dipeptide Amides as Potent and Selective Inhibitors of Candida albicans MyristoylCoA:Protein N-Myristoyltransferase and Identification of Related Tripeptide Inhibitors with Mechanism-Based Antifungal Activity
Devadas, Balekudru, Freeman, Sandra K, Zupec, Mark E, Lu, Hwang-Fun, Nagarajan, Srinivasan R, Kishore, Nandini S, Lodge, Jennifer K, Kuneman, David W, McWherter, Charles A, Vinjamoori, Dutt V, Getman, Daniel P, Gordon, Jeffrey I, Sikorski, James A
Published in Journal of medicinal chemistry (01.08.1997)
Published in Journal of medicinal chemistry (01.08.1997)
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IKK-i and TBK-1 are Enzymatically Distinct from the Homologous Enzyme IKK-2
Kishore, Nandini, Huynh, Q. Khai, Mathialagan, Sumathy, Hall, Troii, Rouw, Sharon, Creely, David, Lange, Gary, Caroll, James, Reitz, Beverley, Donnelly, Ann, Boddupalli, Hymavathi, Combs, Rodney G., Kretzmer, Kuniko, Tripp, Catherine S.
Published in The Journal of biological chemistry (19.04.2002)
Published in The Journal of biological chemistry (19.04.2002)
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Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: Protein N-myristoyltransferase: A new approach to antifungal therapy
Sikorski, James A., Devadas, Balekudru, Zupec, Mark E., Freeman, Sandra K., Brown, David L., Lu, Hwang-Fun, Nagarajan, Srinivasan, Mehta, Pramod P., Wade, Arlene C., Kishore, Nandini S., Bryant, Martin L., Getman, Daniel P., McWherter, Charles A., Gordon, Jeffrey I.
Published in Biopolymers (1997)
Published in Biopolymers (1997)
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Conformationally Constrained [p-(ω-Aminoalkyl)phenacetyl]-l-seryl-l-lysyl Dipeptide Amides as Potent Peptidomimetic Inhibitors of Candida albicans and Human Myristoyl-CoA:Protein N-Myristoyl Transferase
Nagarajan, Srinivasan R, Devadas, Balekudru, Zupec, Mark E, Freeman, Sandra K, Brown, David L, Lu, Hwang-Fun, Mehta, Pramod P, Kishore, Nandini S, McWherter, Charles A, Getman, Daniel P, Gordon, Jeffrey I, Sikorski, James A
Published in Journal of medicinal chemistry (09.05.1997)
Published in Journal of medicinal chemistry (09.05.1997)
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JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production
LaBranche, Timothy P., Jesson, Michael I., Radi, Zaher A., Storer, Chad E., Guzova, Julia A., Bonar, Sheri L., Thompson, Janice M., Happa, Fernando A., Stewart, Zachary S., Zhan, Yutian, Bollinger, Chris S., Bansal, Prashant N., Wellen, Jeremy W., Wilkie, Dean P., Bailey, Steven A., Symanowicz, Peter T., Hegen, Martin, Head, Richard D., Kishore, Nandini, Mbalaviele, Gabriel, Meyer, Debra M.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.11.2012)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.11.2012)
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Protein Kinase Cζ Mediates Cigarette Smoke/Aldehyde- and Lipopolysaccharide-induced Lung Inflammation and Histone Modifications
Yao, Hongwei, Hwang, Jae-woong, Moscat, Jorge, Diaz-Meco, Maria T., Leitges, Michael, Kishore, Nandini, Li, Xiong, Rahman, Irfan
Published in The Journal of biological chemistry (19.02.2010)
Published in The Journal of biological chemistry (19.02.2010)
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Anti-inflammatory effect of a selective IκB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke
Rajendrasozhan, Saravanan, Hwang, Jae-Woong, Yao, Hongwei, Kishore, Nandini, Rahman, Irfan
Published in Pulmonary pharmacology & therapeutics (01.06.2010)
Published in Pulmonary pharmacology & therapeutics (01.06.2010)
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A Selective IKK-2 Inhibitor Blocks NF-κB-dependent Gene Expression in Interleukin-1β-stimulated Synovial Fibroblasts
Kishore, Nandini, Sommers, Cindy, Mathialagan, Sumathy, Guzova, Julia, Yao, Min, Hauser, Scott, Huynh, Khai, Bonar, Sheri, Mielke, Cindy, Albee, Lee, Weier, Richard, Graneto, Matthew, Hanau, Cathleen, Perry, Thao, Tripp, Catherine S.
Published in The Journal of biological chemistry (29.08.2003)
Published in The Journal of biological chemistry (29.08.2003)
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A Novel, Highly Selective, Tight Binding IκB Kinase-2 (IKK-2) Inhibitor: A Tool to Correlate IKK-2 Activity to the Fate and Functions of the Components of the Nuclear Factor-κB Pathway in Arthritis-Relevant Cells and Animal Models
Mbalaviele, Gabriel, Sommers, Cynthia D., Bonar, Sheri L., Mathialagan, Sumathy, Schindler, John F., Guzova, Julia A., Shaffer, Alexander F., Melton, Michele A., Christine, Lori J., Tripp, Catherine S., Chiang, Po-Chang, Thompson, David C., Hu, Yiding, Kishore, Nandini
Published in The Journal of pharmacology and experimental therapeutics (01.04.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2009)
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Novel Insights into the Cellular Mechanisms of the Anti-inflammatory Effects of NF-κB Essential Modulator Binding Domain Peptides
Baima, Eric T., Guzova, Julia A., Mathialagan, Sumathy, Nagiec, Eva E., Hardy, Medora M., Song, Lily R., Bonar, Sheri L., Weinberg, Robin A., Selness, Shaun R., Woodard, Scott S., Chrencik, Jill, Hood, William F., Schindler, John F., Kishore, Nandini, Mbalaviele, Gabriel
Published in The Journal of biological chemistry (30.04.2010)
Published in The Journal of biological chemistry (30.04.2010)
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Combined use of pharmacokinetic modeling and a steady-state delivery approach allows early assessment of IκB kinase-2 (IKK-2) target safety and efficacy
Chiang, Po-Chang, Kishore, Nandini N., Thompson, David C.
Published in Journal of pharmaceutical sciences (01.03.2010)
Published in Journal of pharmaceutical sciences (01.03.2010)
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