Targeted protein degradation via intramolecular bivalent glues
Hsia, Oliver, Hinterndorfer, Matthias, Cowan, Angus D., Iso, Kentaro, Ishida, Tasuku, Sundaramoorthy, Ramasubramanian, Nakasone, Mark A., Imrichova, Hana, Schätz, Caroline, Rukavina, Andrea, Husnjak, Koraljka, Wegner, Martin, Correa-Sáez, Alejandro, Craigon, Conner, Casement, Ryan, Maniaci, Chiara, Testa, Andrea, Kaulich, Manuel, Dikic, Ivan, Winter, Georg E., Ciulli, Alessio
Published in Nature (London) (07.03.2024)
Published in Nature (London) (07.03.2024)
Get full text
Journal Article
Mixed-Linkage Ubiquitin Chains Send Mixed Messages
Nakasone, Mark A., Livnat-Levanon, Nurit, Glickman, Michael H., Cohen, Robert E., Fushman, David
Published in Structure (London) (07.05.2013)
Published in Structure (London) (07.05.2013)
Get full text
Journal Article
A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants
Gabrielsen, Mads, Buetow, Lori, Nakasone, Mark A., Ahmed, Syed Feroj, Sibbet, Gary J., Smith, Brian O., Zhang, Wei, Sidhu, Sachdev S., Huang, Danny T.
Published in Molecular cell (19.10.2017)
Published in Molecular cell (19.10.2017)
Get full text
Journal Article
Unique Structural, Dynamical, and Functional Properties of K11-Linked Polyubiquitin Chains
Castañeda, Carlos A., Kashyap, Tanuja R., Nakasone, Mark A., Krueger, Susan, Fushman, David
Published in Structure (London) (02.07.2013)
Published in Structure (London) (02.07.2013)
Get full text
Journal Article
Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders
Kroupova, Alena, Spiteri, Valentina A., Rutter, Zoe J., Furihata, Hirotake, Darren, Darren, Ramachandran, Sarath, Chakraborti, Sohini, Haubrich, Kevin, Pethe, Julie, Gonzales, Denzel, Wijaya, Andre J., Rodriguez-Rios, Maria, Sturbaut, Manon, Lynch, Dylan M., Farnaby, William, Nakasone, Mark A., Zollman, David, Ciulli, Alessio
Published in Nature communications (15.10.2024)
Published in Nature communications (15.10.2024)
Get full text
Journal Article
Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins
Castañeda, Carlos A., Dixon, Emma K., Walker, Olivier, Chaturvedi, Apurva, Nakasone, Mark A., Curtis, Joseph E., Reed, Megan R., Krueger, Susan, Cropp, T. Ashton, Fushman, David
Published in Structure (London) (01.03.2016)
Published in Structure (London) (01.03.2016)
Get full text
Journal Article
Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit
Chojnacki, Michal, Mansour, Wissam, Hameed, Dharjath S., Singh, Rajesh K., El Oualid, Farid, Rosenzweig, Rina, Nakasone, Mark A., Yu, Zanlin, Glaser, Fabian, Kay, Lewis E., Fushman, David, Ovaa, Huib, Glickman, Michael H.
Published in Cell chemical biology (20.04.2017)
Published in Cell chemical biology (20.04.2017)
Get full text
Journal Article
Chemical Synthesis of Phosphorylated Ubiquitin and Diubiquitin Exposes Positional Sensitivities of E1-E2 Enzymes and Deubiquitinases
Bondalapati, Somasekhar, Mansour, Wissam, Nakasone, Mark A., Maity, Suman Kumar, Glickman, Michael H., Brik, Ashraf
Published in Chemistry : a European journal (11.05.2015)
Published in Chemistry : a European journal (11.05.2015)
Get full text
Journal Article
Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases
Chatrin, Chatrin, Gabrielsen, Mads, Buetow, Lori, Nakasone, Mark A, Ahmed, Syed F, Sumpton, David, Sibbet, Gary J, Smith, Brian O, Huang, Danny T
Published in Science advances (01.09.2020)
Published in Science advances (01.09.2020)
Get full text
Journal Article
Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway
Nakasone, Mark A., Lewis, Timothy A., Walker, Olivier, Thakur, Anita, Mansour, Wissam, Castañeda, Carlos A., Goeckeler-Fried, Jennifer L., Parlati, Frank, Chou, Tsui-Fen, Hayat, Ortal, Zhang, Daoning, Camara, Christina M., Bonn, Steven M., Nowicka, Urszula K., Krueger, Susan, Glickman, Michael H., Brodsky, Jeffrey L., Deshaies, Raymond J., Fushman, David
Published in Structure (London) (05.12.2017)
Published in Structure (London) (05.12.2017)
Get full text
Journal Article
Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer
Villar, Victor H., Allega, Maria Francesca, Deshmukh, Ruhi, Ackermann, Tobias, Nakasone, Mark A., Vande Voorde, Johan, Drake, Thomas M., Oetjen, Janina, Bloom, Algernon, Nixon, Colin, Müller, Miryam, May, Stephanie, Tan, Ee Hong, Vereecke, Lars, Jans, Maude, Blancke, Gillian, Murphy, Daniel J., Huang, Danny T., Lewis, David Y., Bird, Thomas G., Sansom, Owen J., Blyth, Karen, Sumpton, David, Tardito, Saverio
Published in Nature chemical biology (01.03.2023)
Published in Nature chemical biology (01.03.2023)
Get full text
Journal Article
Disassembly of Lys11 and Mixed Linkage Polyubiquitin Conjugates Provides Insights into Function of Proteasomal Deubiquitinases Rpn11 and Ubp6
Mansour, Wissam, Nakasone, Mark A., von Delbrück, Maximilian, Yu, Zanlin, Krutauz, Daria, Reis, Noa, Kleifeld, Oded, Sommer, Thomas, Fushman, David, Glickman, Michael H.
Published in The Journal of biological chemistry (20.02.2015)
Published in The Journal of biological chemistry (20.02.2015)
Get full text
Journal Article
Characterizing polyubiquitinated forms of the neurodegenerative ubiquitin mutant UBB+1
Chojnacki, Michal, Zhang, Daoning, Talarowska, Monika, Gałecki, Piotr, Szemraj, Janusz, Fushman, David, Nakasone, Mark A.
Published in FEBS letters (01.12.2016)
Published in FEBS letters (01.12.2016)
Get full text
Journal Article
Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function
Kowalczyk, Dominika, Nakasone, Mark A, Smith, Brian O, Huang, Danny T
Published in Life science alliance (09.08.2022)
Published in Life science alliance (09.08.2022)
Get full text
Journal Article
Mechanism of degrader-targeted protein ubiquitinability
Crowe, Charlotte, Nakasone, Mark A, Chandler, Sarah, Craigon, Conner, Sathe, Gajanan, Tatham, Michael H, Makukhin, Nikolai, Hay, Ronald T, Ciulli, Alessio
Published in Science advances (11.10.2024)
Published in Science advances (11.10.2024)
Get full text
Journal Article
Extended ubiquitin species are protein-based DUB inhibitors
Krutauz, Daria, Reis, Noa, Nakasone, Mark A, Siman, Peter, Zhang, Daoning, Kirkpatrick, Donald S, Gygi, Steven P, Brik, Ashraf, Fushman, David, Glickman, Michael H
Published in Nature chemical biology (01.08.2014)
Published in Nature chemical biology (01.08.2014)
Get full text
Journal Article
Base-CP proteasome can serve as a platform for stepwise lid formation
Yu, Zanlin, Livnat-Levanon, Nurit, Kleifeld, Oded, Mansour, Wissam, Nakasone, Mark A, Castaneda, Carlos A, Dixon, Emma K, Fushman, David, Reis, Noa, Pick, Elah, Glickman, Michael H
Published in Bioscience reports (01.06.2015)
Published in Bioscience reports (01.06.2015)
Get full text
Journal Article
Proteomic Identification and Analysis of K63-Linked Ubiquitin Conjugates
Cannon, Joe, Nakasone, Mark, Fushman, David, Fenselau, Catherine
Published in Analytical chemistry (Washington) (20.11.2012)
Published in Analytical chemistry (Washington) (20.11.2012)
Get full text
Journal Article