Precision off-the-shelf natural killer cell therapies for oncology with logic-gated gene circuits
Frankel, Nicholas W., Deng, Han, Yucel, Gozde, Gainer, Marcus, Leemans, Nelia, Lam, Alice, Li, Yongshuai, Hung, Michelle, Lee, Derrick, Lee, Chen-Ting, Banicki, Andrew, Tian, Mengxi, Almudhfar, Niran, Naitmazi, Lawrence, Roguev, Assen, Lee, Seunghee, Wong, Wilson, Gordley, Russell, Lu, Timothy K., Garrison, Brian S.
Published in Cell reports (Cambridge) (28.05.2024)
Published in Cell reports (Cambridge) (28.05.2024)
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257 NOT gate gene circuits expand the range of tumor-associated antigens addressable by CAR-NK and -T cell therapies
Frankel, Nicholas W, Roguev, Assen, Gainer, Marcus, Caradonna, Ippolito I, Hua, Tony, Deng, Han, Yucel, Gozde, Lam, Alice, Li, Yongshuai, Hung, Michelle, Lee, Derrick, Lee, Chen-Ting, Banicki, Andrew, Tian, Mengxi, Almudhfar, Niran, Naitmazi, Lawrence, Gordley, Russell M, Garrison, Brian, Rajangam, Kanya, Lu, Timothy K
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Abstract 1333: Preclinical data supporting the Phase 1 trial design of SENTI-202, a next generation allogeneic logic-gated selective CAR NK cell therapy, engineered to overcome key limitations of first generation cell therapies in AML
Kaveri, Deepika, Chinta, Pearley, Leitner, Elizabeth, Naitmazi, Lawrence, Yucel, Gozde, Tian, Mengxi, Almudhfar, Niran, Deng, Han, Li, Yongshuai, Lam, Alice, Lee, Chen-Ting, Hong, Enping, Emery, Rochelle, Garrison, Brian, Nguyen, Aaron N., Rajangam, Kanya
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 2905: SENTI-301A, an off-the-shelf multi-armed preclinical CAR-NK cell therapy, for the treatment of GPC3 expressing tumors
Ayala, Marcela Guzman, Kaveri, Deepika, Hong, Enping, Leitner, Elizabeth, Wong, Priscilla, Ponek, Ronni, Naitmazi, Lawrence, Chinta, Pearley, Gorman, Wesley, Tian, Mengxi, Almudhfar, Niran, Lee, Kelly, Frankel, Nicholas, Junca, Alba Gonzalez, Gordley, Russell, Lee, Philip, Lu, Timothy, Rajangam, Kanya
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 2902: Off-the-Shelf CAR-NK cells engineered to express calibrated release IL-15 exhibit enhanced persistence and anti-tumor activities
Lee, Chen-Ting, Hung, Michelle, Banicki, Andrew, Song, Wenqi, Almudhfar, Niran, Kaveri, Deepika, Wong, Priscilla, Naitmazi, Lawrence, Guzman, Marcela, Lam, Alice, Yucel, Gozde, Lu, Timothy, Junca, Alba G., Garrison, Brian, Lee, Philip
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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228 Multi-arming and regulator dial gene circuits tackle key challenges in solid tumors
Marcela Guzman Ayala, Hung, Michelle, Kaveri, Deepika, Cottman, Rebecca, Leitner, Elizabeth, Wong, Priscilla, Ponek, Ronni, Hong, Enping, Shah, Manan, Banicki, Andrew, Naitmazi, Lawrence, Lee, Kelly, Gorman, Wesley, Gordley, Russell, Lee, Philip, Lu, Timothy
Published in Journal for immunotherapy of cancer (01.11.2022)
Published in Journal for immunotherapy of cancer (01.11.2022)
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