Miniproteins as a Powerful Modality in Drug Development
Crook, Zachary R., Nairn, Natalie W., Olson, James M.
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.04.2020)
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.04.2020)
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Journal Article
CYpHER: catalytic extracellular targeted protein degradation with high potency and durable effect
Crook, Zachary R., Sevilla, Gregory P., Young, Pamela, Girard, Emily J., Phi, Tinh-Doan, Howard, Monique L., Price, Jason, Olson, James M., Nairn, Natalie W.
Published in Nature communications (09.10.2024)
Published in Nature communications (09.10.2024)
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A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure
Cook Sangar, Michelle L, Girard, Emily J, Hopping, Gene, Yin, Chunfeng, Pakiam, Fiona, Brusniak, Mi-Youn, Nguyen, Elizabeth, Ruff, Raymond, Gewe, Mesfin M, Byrnes-Blake, Kelly, Nairn, Natalie W, Miller, Dennis M, Mehlin, Christopher, Strand, Andrew D, Mhyre, Andrew J, Correnti, Colin E, Strong, Roland K, Simon, Julian A, Olson, James M
Published in Science translational medicine (04.03.2020)
Published in Science translational medicine (04.03.2020)
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Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager
Crook, Zachary R, Girard, Emily J, Sevilla, Gregory P, Brusniak, Mi-Youn, Rupert, Peter B, Friend, Della J, Gewe, Mesfin M, Clarke, Midori, Lin, Ida, Ruff, Raymond, Pakiam, Fiona, Phi, Tinh-Doan, Bandaranayake, Ashok, Correnti, Colin E, Mhyre, Andrew J, Nairn, Natalie W, Strong, Roland K, Olson, James M
Published in Science translational medicine (18.05.2022)
Published in Science translational medicine (18.05.2022)
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Cysteine as a Monothiol Reducing Agent to Prevent Copper-Mediated Oxidation of Interferon Beta During PEGylation by CuAAC
Nairn, Natalie W, Bariola, Pauline A, Graddis, Thomas J, VanBrunt, Michael Pete, Wang, Aijun, Li, Gary, Grabstein, Kenneth
Published in Bioconjugate chemistry (21.10.2015)
Published in Bioconjugate chemistry (21.10.2015)
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Development of Copper-Catalyzed Azide–Alkyne Cycloaddition for Increased in Vivo Efficacy of Interferon β‑1b by Site-Specific PEGylation
Nairn, Natalie W, Shanebeck, Kurt D, Wang, Aijun, Graddis, Thomas J, VanBrunt, Michael Pete, Thornton, Kenneth C, Grabstein, Kenneth
Published in Bioconjugate chemistry (17.10.2012)
Published in Bioconjugate chemistry (17.10.2012)
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AZ17: a new bispecific drug targeting IL-6 and IL-23 with potential clinical use—improves psoriasis in a human xenograft transplantation model
Stenderup, Karin, Rosada, Cecilia, Shanebeck, Kurt, Brady, William, Van Brunt, Michael P., King, Gordon, Marelli, Marcello, Slagle, Paul, Xu, Hengyu, Nairn, Natalie W., Johnson, Jeffrey, Wang, Aijun A., Li, Gary, Thornton, Kenneth C., Dam, Tomas N., Grabstein, Kenneth H.
Published in Protein engineering, design and selection (01.10.2015)
Published in Protein engineering, design and selection (01.10.2015)
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Processing of N-Terminal Unnatural Amino Acids in Recombinant Human Interferon-β in Escherichia coli
Wang, Aijun, Winblade Nairn, Natalie, Johnson, Richard S, Tirrell, David A, Grabstein, Kenneth
Published in Chembiochem : a European journal of chemical biology (25.01.2008)
Published in Chembiochem : a European journal of chemical biology (25.01.2008)
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Journal Article
CYpHER: Catalytic extracellular targeted protein degradation with high potency and durable effect
Crook, Zachary R, Sevilla, Gregory P, Young, Pamela, Girard, Emily J, Phi, Tinh-Doan, Howard, Monique, Price, Jason, Olson, James M, Nairn, Natalie W
Published in bioRxiv (23.04.2024)
Published in bioRxiv (23.04.2024)
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Paper
Abstract 1043: Advances in cystine-dense peptide (CDP) screening and therapeutic applications
Crook, Zachary R., Girard, Emily J., Sevilla, Gregory P., Brusniak, Mi-Youn, Rupert, Peter B., Friend, Della J., Gewe, Mesfin M., Clarke, Midori, Lin, Ida, Ruff, Raymond, Phi, Doan, Bandaranayake, Ashok, Correnti, Colin E., Mhyre, Andrew J., Nairn, Natalie W., Strong, Roland K., Olson, James M.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Development of Copper-Catalyzed Azide-Alkyne Cycloaddition for Increased in Vivo Efficacy of Interferon [Beta]-1b by Site-Specific PEGylation
Nairn, Natalie W, Shanebeck, Kurt D, Wang, Aijun, Graddis, Thomas J, VanBrunt, Michael Pete, Thornton, Kenneth C, Grabstein, Kenneth
Published in Bioconjugate chemistry (17.10.2012)
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Published in Bioconjugate chemistry (17.10.2012)
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Cancer vaccines and immunotherapies: emerging perspectives
Henderson, Robert A., Mossman, Sally, Nairn, Natalie, Cheever, Martin A.
Published in Vaccine (18.03.2005)
Published in Vaccine (18.03.2005)
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Conference Proceeding
PD-L1 BINDING PEPTIDES AND PEPTIDE COMPLEXES AND METHODS OF USE THEREOF
CROOK, Zachary, CORRENTI, Colin, OLSON, James, NAIRN, Natalie Winblade
Year of Publication 23.10.2024
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Year of Publication 23.10.2024
Patent
PD-L1 BINDING PEPTIDES AND PEPTIDE COMPLEXES AND METHODS OF USE THEREOF
CROOK, Zachary, CORRENTI, Colin, OLSON, James, NAIRN, Natalie Winblade
Year of Publication 29.08.2024
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Year of Publication 29.08.2024
Patent
PD-L1 BINDING PEPTIDES AND PEPTIDE COMPLEXES AND METHODS OF USE THEREOF
CROOK, Zachary, CORRENTI, Colin, OLSON, James, NAIRN, Natalie Winblade
Year of Publication 04.10.2023
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Year of Publication 04.10.2023
Patent
PD-L1 BINDING PEPTIDES AND PEPTIDE COMPLEXES AND METHODS OF USE THEREOF
CROOK, Zachary, CORRENTI, Colin, OLSON, James, NAIRN, Natalie Winblade
Year of Publication 29.06.2023
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Year of Publication 29.06.2023
Patent
TRUNCATED CARTILAGE-HOMING PEPTIDES AND PEPTIDE COMPLEXES AND METHODS OF USE THEREOF
STROUD, Mark, PRESNELL, Scott, JOCHHEIM, Claudia, NAIRN, Natalie Winblade
Year of Publication 19.10.2022
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Year of Publication 19.10.2022
Patent