Recent progress on third generation covalent EGFR inhibitors
Cheng, Hengmiao, Nair, Sajiv K., Murray, Brion W.
Published in Bioorganic & medicinal chemistry letters (15.04.2016)
Published in Bioorganic & medicinal chemistry letters (15.04.2016)
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Journal Article
1,2-Difunctionalized bicyclo[1.1.1]pentanes: Long–sought-after mimetics for ortho/meta-substituted arenes
Zhao, Jin-Xin, Chang, Yu-Xuan, He, Chi, Burke, Benjamin J., Collins, Michael R., Del Bel, Matthew, Elleraas, Jeff, Gallego, Gary M., Montgomery, T. Patrick, Mousseau, James J., Nair, Sajiv K., Perry, Matthew A., Spangler, Jillian E., Vantourout, Julien C., Baran, Phil S.
Published in Proceedings of the National Academy of Sciences - PNAS (13.07.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (13.07.2021)
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Journal Article
Construction of Isoquinolone Scaffolds on DNA via Rhodium(III)-Catalyzed C–H Activation
Ye, Yusong, Berry, Madeline, Bock, William J., Cheng, Kunpeng, Nair, Sajiv K., Park, Christiana S., Patman, Ryan L., Sakata, Sylvie, Tran-Dubé, Michelle, Donaldson, Joyann S., Yang, Guanyu, Liu, Guansai
Published in Organic letters (26.04.2024)
Published in Organic letters (26.04.2024)
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Journal Article
Design and Synthesis of Functionally Active 5‑Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1
Gallego, Rebecca A., Bernier, Louise, Chen, Hui, Cho-Schultz, Sujin, Chung, Loanne, Collins, Michael, Del Bel, Matthew, Elleraas, Jeff, Costa Jones, Cinthia, Cronin, Ciaran N., Edwards, Martin, Fang, Xu, Fisher, Timothy, He, Mingying, Hoffman, Jacqui, Huo, Ruiduan, Jalaie, Mehran, Johnson, Eric, Johnson, Ted W., Kania, Robert S., Kraus, Manfred, Lafontaine, Jennifer, Le, Phuong, Liu, Tongnan, Maestre, Michael, Matthews, Jean, McTigue, Michele, Miller, Nichol, Mu, Qiming, Qin, Xulong, Ren, Shijian, Richardson, Paul, Rohner, Allison, Sach, Neal, Shao, Li, Smith, Graham, Su, Ruirui, Sun, Bin, Timofeevski, Sergei, Tran, Phuong, Wang, Shuiwang, Wang, Wei, Zhou, Ru, Zhu, Jinjiang, Nair, Sajiv K.
Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
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Journal Article
Multifaceted Substrate–Ligand Interactions Promote the Copper-Catalyzed Hydroboration of Benzylidenecyclobutanes and Related Compounds
Kang, Taeho, Erbay, Tuğçe G, Xu, Kane L, Gallego, Gary M, Burtea, Alexander, Nair, Sajiv K, Patman, Ryan L, Zhou, Ru, Sutton, Scott C, McAlpine, Indrawan J, Liu, Peng, Engle, Keary M
Published in ACS catalysis (06.11.2020)
Published in ACS catalysis (06.11.2020)
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Journal Article
Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR
Planken, Simon, Behenna, Douglas C, Nair, Sajiv K, Johnson, Theodore O, Nagata, Asako, Almaden, Chau, Bailey, Simon, Ballard, T. Eric, Bernier, Louise, Cheng, Hengmiao, Cho-Schultz, Sujin, Dalvie, Deepak, Deal, Judith G, Dinh, Dac M, Edwards, Martin P, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle, Kania, Robert S, Kath, John C, Matthews, Jean, Murray, Brion W, Niessen, Sherry, Orr, Suvi T. M, Pairish, Mason, Sach, Neal W, Shen, Hong, Shi, Manli, Solowiej, James, Tran, Khanh, Tseng, Elaine, Vicini, Paolo, Wang, Yuli, Weinrich, Scott L, Zhou, Ru, Zientek, Michael, Liu, Longqing, Luo, Yiqin, Xin, Shuibo, Zhang, Chengyi, Lafontaine, Jennifer
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Journal Article
Synthesis of Small 3‑Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry
McAlpine, Indrawan, Tran-Dubé, Michelle, Wang, Fen, Scales, Stephanie, Matthews, Jean, Collins, Michael R, Nair, Sajiv K, Nguyen, Mary, Bian, Jianwei, Alsina, Luis Martinez, Sun, Jianmin, Zhong, Jiaying, Warmus, Joseph S, O’Neill, Brian T
Published in Journal of organic chemistry (17.07.2015)
Published in Journal of organic chemistry (17.07.2015)
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Journal Article
The development and SAR of pyrrolidine carboxamide 11β-HSD1 inhibitors
Cheng, Hengmiao, Hoffman, Jacqui, Le, Phuong, Nair, Sajiv K., Cripps, Stephan, Matthews, Jean, Smith, Christopher, Yang, Michele, Kupchinsky, Stan, Dress, Klaus, Edwards, Martin, Cole, Bridget, Walters, Evan, Loh, Christine, Ermolieff, Jacques, Fanjul, Andrea, Bhat, Ganesh B., Herrera, Jocelyn, Pauly, Tom, Hosea, Natilie, Paderes, Genevieve, Rejto, Paul
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Journal Article
Preparation and physicochemical characterization of a novel water-soluble prodrug of carbamazepine
Hemenway, Jeffrey N., Jarho, Pekka, Henri, John T., Nair, Sajiv K., VanderVelde, David, Georg, Gunda I., Stella, Valentino J.
Published in Journal of pharmaceutical sciences (01.04.2010)
Published in Journal of pharmaceutical sciences (01.04.2010)
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Journal Article
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275
Siu, Michael, Johnson, Theodore O., Wang, Yong, Nair, Sajiv K., Taylor, Wendy D., Cripps, Stephan J., Matthews, Jean J., Edwards, Martin P., Pauly, Thomas A., Ermolieff, Jacques, Castro, Arturo, Hosea, Natilie A., LaPaglia, Amy, Fanjul, Andrea N., Vogel, Jennifer E.
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
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Journal Article
Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility
Nieman, James A., Nair, Sajiv K., Heasley, Steven E., Schultz, Brenda L., Zerth, Herbert M., Nugent, Richard A., Chen, Ke, Stephanski, Kevin J., Hopkins, Todd A., Knechtel, Mary L., Oien, Nancee L., Wieber, Janet L., Wathen, Michael W.
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Journal Article
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Strategies to eliminate reactive metabolites
Nair, Sajiv K., Matthews, Jean J., Cripps, Stephan J., Cheng, Hengmiao, Hoffman, Jacqui E., Smith, Christopher, Kupchinsky, Stanley, Siu, Michael, Taylor, Wendy D., Wang, Yong, Johnson, Theodore O., Dress, Klaus R., Edwards, Martin P., Zhou, Sue, Hosea, Natilie A., LaPaglia, Amy, Kang, Ping, Castro, Arturo, Ermolieff, Jacques, Fanjul, Andrea, Vogel, Jennifer E., Rejto, Paul, Dalvie, Deepak
Published in Bioorganic & medicinal chemistry letters (15.04.2013)
Published in Bioorganic & medicinal chemistry letters (15.04.2013)
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Journal Article
Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models
Prasanna, Ganesh, Fortner, Jay, Xiang, Cathie, Zhang, Eric, Carreiro, Samantha, Anderson, Scott, Sartnurak, Soisurin, Wu, Grace, Gukasyan, Hovhannes, Niesman, Michael, Nair, Sajiv, Rui, Eugene, Lafontaine, Jennifer, Almaden, Chau Doan, Wells, Peter, Krauss, Achim
Published in Experimental eye research (01.11.2009)
Published in Experimental eye research (01.11.2009)
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Journal Article
2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3- b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases
Schnute, Mark E., Anderson, David J., Brideau, Roger J., Ciske, Fred L., Collier, Sarah A., Cudahy, Michele M., Eggen, MariJean, Genin, Michael J., Hopkins, Todd A., Judge, Thomas M., Kim, Euibong J., Knechtel, Mary L., Nair, Sajiv K., Nieman, James A., Oien, Nancee L., Scott, Allen, Tanis, Steven P., Vaillancourt, Valerie A., Wathen, Michael W., Wieber, Janet L.
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
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Journal Article
Total Synthesis and Evaluation of C26-Hydroxyepothilone D Derivatives for Photoaffinity Labeling of β-Tubulin
Reiff, Emily A, Nair, Sajiv K, Henri, John T, Greiner, Jack F, Reddy, Bollu S, Chakrasali, Ramappa, David, Sunil A, Chiu, Ting-Lan, Amin, Elizabeth A, Himes, Richard H, Vander Velde, David G, Georg, Gunda I
Published in Journal of organic chemistry (01.01.2010)
Published in Journal of organic chemistry (01.01.2010)
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Journal Article
Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells
Hutt, Oliver E., Reddy, Bollu S., Nair, Sajiv K., Reiff, Emily A., Henri, John T., Greiner, Jack F., Chiu, Ting-Lan, VanderVelde, David G., Amin, Elizabeth A., Himes, Richard H., Georg, Gunda I.
Published in Bioorganic & medicinal chemistry letters (01.09.2008)
Published in Bioorganic & medicinal chemistry letters (01.09.2008)
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Journal Article
Total synthesis and evaluation of 22-(3-azidobenzoyloxy)methyl epothilone C for photoaffinity labeling of β-tubulin
Hutt, Oliver E., Inagaki, Jun, Reddy, Bollu S., Nair, Sajiv K., Reiff, Emily A., Henri, John T., Greiner, Jack F., VanderVelde, David G., Chiu, Ting-Lan, Amin, Elizabeth A., Himes, Richard H., Georg, Gunda I.
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
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Journal Article
Synthesis of Cryptophycins via an N-Acyl-β-lactam Macrolactonization
Vidya, Ramdas, Eggen, MariJean, Nair, Sajiv K, Georg, Gunda I, Himes, Richard H
Published in Journal of organic chemistry (12.12.2003)
Published in Journal of organic chemistry (12.12.2003)
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Journal Article
Total Synthesis of Cryptophycin-24 (Arenastatin A) Amenable to Structural Modifications in the C16 Side Chain
Eggen, MariJean, Mossman, Craig J, Buck, Suzanne B, Nair, Sajiv K, Bhat, Laxminarayan, Ali, Syed M, Reiff, Emily A, Boge, Thomas C, Georg, Gunda I
Published in Journal of organic chemistry (17.11.2000)
Published in Journal of organic chemistry (17.11.2000)
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