Identification and profiling of 3,5-dimethyl-isoxazole-4-carboxylic acid [2-methyl-4-((2S,3′S)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)phenyl] amide as histamine H3 receptor antagonist for the treatment of depression
Gao, Zhongli, Hurst, William J., Czechtizky, Werngard, Hall, Daniel, Moindrot, Nicolas, Nagorny, Raisa, Pichat, Philippe, Stefany, David, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
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Identification and Characterization of Two Neuromedin U Receptors Differentially Expressed in Peripheral Tissues and the Central Nervous System
Raddatz, Rita, Wilson, Amy E., Artymyshyn, Roman, Bonini, James A., Borowsky, Beth, Boteju, Lakmal W., Zhou, Siqun, Kouranova, Evguenia V., Nagorny, Raisa, Guevarra, Maricel S., Dai, Meng, Lerman, Gabriel S., Vaysse, Pierre J., Branchek, Theresa A., Gerald, Christophe, Forray, Carlos, Adham, Nika
Published in The Journal of biological chemistry (20.10.2000)
Published in The Journal of biological chemistry (20.10.2000)
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Identification and profiling of 3,5-dimethyl-isoxazole-4-carboxylic acid [2-methyl-4-((2S,3 ' S)-2-methyl-[1,3 ']bipyrrolidinyl-1 '-yl)phenyl] amide as histamine H-3 receptor antagonist for the treatment of depression
Gao, Zhongli, Hurst, William J., Czechtizky, Werngard, Hall, Daniel, Moindrot, Nicolas, Nagorny, Raisa, Pichat, Philippe, Stefany, David, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
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Journal Article
Design and synthesis of a novel series of histamine H-3 receptor antagonists through a scaffold hopping strategy
Gao, Zhongli, Hurst, William J., Hall, Daniel, Hartung, Ryan, Reynolds, William, Kang, Jiesheng, Nagorny, Raisa, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry (01.02.2015)
Published in Bioorganic & medicinal chemistry (01.02.2015)
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Synthesis, characterization, and biological assessment of the four stereoisomers of the H-3 receptor antagonist 5-fluoro-2-methyl-N-[2-methyl-4-(2-methyl[1,3 ']bipyrrolidinyl-1 '-yl)phenyl]benzamide
Gao, Zhongli, Hurst, William J., Guillot, Etienne, Nagorny, Raisa, Pruniaux, Marie-Pierre, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
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Synthesis, characterization, and biological assessment of the four stereoisomers of the H3 receptor antagonist 5-fluoro-2-methyl-N-[2-methyl-4-(2-methyl[1,3a2]bipyrrolidinyl-1a 2-yl)phenyl]benzamide
Gao, Zhongli, Hurst, William, Guillot, Etienne, Nagorny, Raisa, Pruniaux, Marie-Pierre, Hendrix, James, George, Pascal
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
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Journal Article
Discovery of a potent, selective, and orally bioavailable histamine H-3 receptor antagonist SAR110068 for the treatment of sleep-wake disorders
Gao, Zhongli, Hurst, William J., Czechtizky, Werngard, Francon, Dominique, Griebel, Guy, Nagorny, Raisa, Pichat, Philippe, Schwink, Lothar, Stengelin, Siegfried, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry letters (15.11.2013)
Published in Bioorganic & medicinal chemistry letters (15.11.2013)
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Journal Article
Design and synthesis of a novel series of histamine H sub(3) receptor antagonists through a scaffold hopping strategy
Gao, Zhongli, Hurst, William J, Hall, Daniel, Hartung, Ryan, Reynolds, William, Kang, Jiesheng, Nagorny, Raisa, Hendrix, James A, George, Pascal G
Published in Bioorganic & medicinal chemistry (01.02.2015)
Published in Bioorganic & medicinal chemistry (01.02.2015)
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Journal Article
Identification and profiling of 3,5-dimethyl-isoxazole-4-carboxylic acid [2-methyl-4-((2S,3a2S)-2-methyl-[1,3a2]bipyrrolidinyl-1a2-yl)phe nyl] amide as histamine H3 receptor antagonist for the treatment of depression
Gao, Zhongli, Hurst, William, Czechtizky, Werngard, Hall, Daniel, Moindrot, Nicolas, Nagorny, Raisa, Pichat, Philippe, Stefany, David, Hendrix, James, George, Pascal
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
Get full text
Journal Article
Design and synthesis of a novel series of histamine H3 receptor antagonists through a scaffold hopping strategy
Gao, Zhongli, Hurst, William J., Hall, Daniel, Hartung, Ryan, Reynolds, William, Kang, Jiesheng, Nagorny, Raisa, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry (01.02.2015)
Published in Bioorganic & medicinal chemistry (01.02.2015)
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Journal Article
Synthesis, characterization, and biological assessment of the four stereoisomers of the H3 receptor antagonist 5-fluoro-2-methyl-N-[2-methyl-4-(2-methyl[1,3′]bipyrrolidinyl-1′-yl)phenyl]benzamide
Gao, Zhongli, Hurst, William J., Guillot, Etienne, Nagorny, Raisa, Pruniaux, Marie-Pierre, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
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Journal Article
Discovery of a potent, selective, and orally bioavailable histamine H3 receptor antagonist SAR110068 for the treatment of sleepawake disorders
Gao, Zhongli, Hurst, William, Czechtizky, Werngard, Francon, Dominique, Griebel, Guy, Nagorny, Raisa, Pichat, Philippe, Schwink, Lothar, Stengelin, Siegfried, Hendrix, James, George, Pascal
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
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Journal Article
Discovery of aryl ureas and aryl amides as potent and selective histamine H-3 receptor antagonists for the treatment of obesity (Part I)
Gao, Zhongli, Hurst, William J., Guillot, Etienne, Czechtizky, Werngard, Lukasczyk, Ulrike, Nagorny, Raisa, Pruniaux, Marie-Pierre, Schwink, Lothar, Sanchez, Juan Antonio, Stengelin, Siegfried, Tang, Lei, Winkler, Irvin, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
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Journal Article
Discovery of aryl ureas and aryl amides as potent and selective histamine H-3 receptor antagonists for the treatment of obesity (Part II)
Gao, Zhongli, Hurst, William J., Guillot, Etienne, Czechtizky, Werngard, Lukasczyk, Ulrike, Nagorny, Raisa, Pruniaux, Marie-Pierre, Schwink, Lothar, Sanchez, Juan Antonio, Stengelin, Siegfried, Tang, Lei, Winkler, Irvin, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
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Journal Article
Discovery of a potent, selective, and orally bioavailable histamine H3 receptor antagonist SAR110068 for the treatment of sleep–wake disorders
Gao, Zhongli, Hurst, William J., Czechtizky, Werngard, Francon, Dominique, Griebel, Guy, Nagorny, Raisa, Pichat, Philippe, Schwink, Lothar, Stengelin, Siegfried, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry letters (15.11.2013)
Published in Bioorganic & medicinal chemistry letters (15.11.2013)
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Journal Article
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (Part I)
Gao, Zhongli, Hurst, William J., Guillot, Etienne, Czechtizky, Werngard, Lukasczyk, Ulrike, Nagorny, Raisa, Pruniaux, Marie-Pierre, Schwink, Lothar, Sanchez, Juan Antonio, Stengelin, Siegfried, Tang, Lei, Winkler, Irvin, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
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Journal Article
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (Part II)
Gao, Zhongli, Hurst, William J., Guillot, Etienne, Czechtizky, Werngard, Lukasczyk, Ulrike, Nagorny, Raisa, Pruniaux, Marie-Pierre, Schwink, Lothar, Sanchez, Juan Antonio, Stengelin, Siegfried, Tang, Lei, Winkler, Irvin, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
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Journal Article
Synthesis, characterization, and biological assessment of the four stereoisomers of the H(3) receptor antagonist 5-fluoro-2-methyl-N-[2-methyl-4-(2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]benzamide
Gao, Zhongli, Hurst, William J, Guillot, Etienne, Nagorny, Raisa, Pruniaux, Marie-Pierre, Hendrix, James A, George, Pascal G
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Get full text
Journal Article
Identification and profiling of 3,5-dimethyl-isoxazole-4-carboxylic acid [2-methyl-4-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)phenyl] amide as histamine H(3) receptor antagonist for the treatment of depression
Gao, Zhongli, Hurst, William J, Czechtizky, Werngard, Hall, Daniel, Moindrot, Nicolas, Nagorny, Raisa, Pichat, Philippe, Stefany, David, Hendrix, James A, George, Pascal G
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
Get full text
Journal Article