Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer
Nagathihalli, Nagaraj S, Castellanos, Jason A, Shi, Chanjuan, Beesetty, Yugandhar, Reyzer, Michelle L, Caprioli, Richard, Chen, Xi, Walsh, Alex J, Skala, Melissa C, Moses, Harold L, Merchant, Nipun B
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2015)
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2015)
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Journal Article
Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer
Nagathihalli, Nagaraj S, Castellanos, Jason A, Lamichhane, Purushottam, Messaggio, Fanuel, Shi, Chanjuan, Dai, Xizi, Rai, Priyamvada, Chen, Xi, VanSaun, Michael N, Merchant, Nipun B
Published in Cancer research (Chicago, Ill.) (01.11.2018)
Published in Cancer research (Chicago, Ill.) (01.11.2018)
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Journal Article
Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer
Totiger, Tulasigeri M, Srinivasan, Supriya, Jala, Venkatakrishna R, Lamichhane, Purushottam, Dosch, Austin R, Gaidarski, 3rd, Alexander A, Joshi, Chandrashekhar, Rangappa, Shobith, Castellanos, Jason, Vemula, Praveen Kumar, Chen, Xi, Kwon, Deukwoo, Kashikar, Nilesh, VanSaun, Michael, Merchant, Nipun B, Nagathihalli, Nagaraj S
Published in Molecular cancer therapeutics (01.02.2019)
Published in Molecular cancer therapeutics (01.02.2019)
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Journal Article
Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response
Walsh, Alex J, Castellanos, Jason A, Nagathihalli, Nagaraj S, Merchant, Nipun B, Skala, Melissa C
Published in Pancreas (01.07.2016)
Published in Pancreas (01.07.2016)
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Journal Article
Tobacco Carcinogen-Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer
Srinivasan, Supriya, Totiger, Tulasigeri, Shi, Chanjuan, Castellanos, Jason, Lamichhane, Purushottam, Dosch, Austin R, Messaggio, Fanuel, Kashikar, Nilesh, Honnenahally, Kumaraswamy, Ban, Yuguang, Merchant, Nipun B, VanSaun, Michael, Nagathihalli, Nagaraj S
Published in Cancer research (Chicago, Ill.) (01.11.2018)
Published in Cancer research (Chicago, Ill.) (01.11.2018)
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Journal Article
Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells
Nagathihalli, Nagaraj S, Castellanos, Jason A, VanSaun, Michael N, Dai, Xizi, Ambrose, Mahogany, Guo, Qiaozhi, Xiong, Yanhua, Merchant, Nipun B
Published in Oncotarget (04.10.2016)
Published in Oncotarget (04.10.2016)
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Journal Article
Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin
Nagathihalli, Nagaraj S, Massion, Pierre P, Gonzalez, Adriana L, Lu, Pengcheng, Datta, Pran K
Published in Molecular cancer therapeutics (01.11.2012)
Published in Molecular cancer therapeutics (01.11.2012)
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Journal Article
Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer
Datta, Jashodeep, Dai, Xizi, Bianchi, Anna, De Castro Silva, Iago, Mehra, Siddharth, Garrido, Vanessa T., Lamichhane, Purushottam, Singh, Samara P., Zhou, Zhiqun, Dosch, Austin R., Messaggio, Fanuel, Ban, Yuguang, Umland, Oliver, Hosein, Peter J., Nagathihalli, Nagaraj S., Merchant, Nipun B.
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2022)
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2022)
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Journal Article
Targeting the transforming growth factor-beta signaling pathway in human cancer
Nagaraj, Nagathihalli S, Datta, Pran K
Published in Expert opinion on investigational drugs (01.01.2010)
Published in Expert opinion on investigational drugs (01.01.2010)
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Journal Article
Targeting Tumor-Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer
Dosch, Austin R, Singh, Samara, Dai, Xizi, Mehra, Siddharth, Silva, Iago De Castro, Bianchi, Anna, Srinivasan, Supriya, Gao, Zhen, Ban, Yuguang, Chen, Xi, Banerjee, Sulagna, Nagathihalli, Nagaraj S, Datta, Jashodeep, Merchant, Nipun B
Published in Molecular cancer therapeutics (01.11.2021)
Published in Molecular cancer therapeutics (01.11.2021)
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Journal Article
Interleukin-1 signaling in solid organ malignancies
Dosch, Austin R., Singh, Samara, Nagathihalli, Nagaraj S., Datta, Jashodeep, Merchant, Nipun B.
Published in Biochimica et biophysica acta. Reviews on cancer (01.01.2022)
Published in Biochimica et biophysica acta. Reviews on cancer (01.01.2022)
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Journal Article
Tumor Cell-Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer
Singh, Samara P, Dosch, Austin R, Mehra, Siddharth, De Castro Silva, Iago, Bianchi, Anna, Garrido, Vanessa T, Zhou, Zhiqun, Adams, Andrew, Amirian, Haleh, Box, Edmond W, Sun, Xiaodian, Ban, Yuguang, Datta, Jashodeep, Nagathihalli, Nagaraj S, Merchant, Nipun B
Published in Cancer research (Chicago, Ill.) (15.04.2024)
Published in Cancer research (Chicago, Ill.) (15.04.2024)
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Journal Article
Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer
Datta, Jashodeep, Bianchi, Anna, De Castro Silva, Iago, Deshpande, Nilesh U., Cao, Long Long, Mehra, Siddharth, Singh, Samara, Rafie, Christine, Sun, Xiaodian, Chen, Xi, Dai, Xizi, Colaprico, Antonio, Sharma, Prateek, Dosch, Austin R., Pillai, Asha, Hosein, Peter J., Nagathihalli, Nagaraj S., Komanduri, Krishna V., Wilson, Julie M., Ban, Yuguang, Merchant, Nipun B.
Published in Oncogene (08.07.2022)
Published in Oncogene (08.07.2022)
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Journal Article
Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids
NAGATHIHALLI, Nagaraj S, BEESETTY, Yugandhar, WOOIN LEE, WASHINGTON, M. Kay, XI CHEN, LOCKHART, A. Craig, MERCHANT, Nipun B
Published in Cancer research (Chicago, Ill.) (01.04.2014)
Published in Cancer research (Chicago, Ill.) (01.04.2014)
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Journal Article
Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth
NAGARAJ, Nagathihalli S, WASHINGTON, M. Kay, MERCHANT, Nipun B
Published in Clinical cancer research (01.02.2011)
Published in Clinical cancer research (01.02.2011)
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Journal Article
Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer
Dosch, Austin R, Dai, Xizi, Reyzer, Michelle L, Mehra, Siddharth, Srinivasan, Supriya, Willobee, Brent A, Kwon, Deukwoo, Kashikar, Nilesh, Caprioli, Richard, Merchant, Nipun B, Nagathihalli, Nagaraj S
Published in Molecular cancer research (01.04.2020)
Published in Molecular cancer research (01.04.2020)
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Journal Article
Combined Blockade of MEK and CDK4/6 Pathways Induces Senescence to Improve Survival in Pancreatic Ductal Adenocarcinoma
Willobee, Brent A, Gaidarski, Alexander A, Dosch, Austin R, Castellanos, Jason A, Dai, Xizi, Mehra, Siddharth, Messaggio, Fanuel, Srinivasan, Supriya, VanSaun, Michael N, Nagathihalli, Nagaraj S, Merchant, Nipun B
Published in Molecular cancer therapeutics (01.07.2021)
Published in Molecular cancer therapeutics (01.07.2021)
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