Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases
Markwalder, Jay A, Arnone, Marc R, Benfield, Pamela A, Boisclair, Michael, Burton, Catherine R, Chang, Chong-Hwan, Cox, Sarah S, Czerniak, Philip M, Dean, Charity L, Doleniak, Deborah, Grafstrom, Robert, Harrison, Barbara A, Kaltenbach, Robert F, Nugiel, David A, Rossi, Karen A, Sherk, Susan R, Sisk, Lisa M, Stouten, Pieter, Trainor, George L, Worland, Peter, Seitz, Steven P
Published in Journal of medicinal chemistry (18.11.2004)
Published in Journal of medicinal chemistry (18.11.2004)
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Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 2. Probing the Indeno Ring Substituent Pattern
Nugiel, David A, Vidwans, Anup, Etzkorn, Anna-Marie, Rossi, Karen A, Benfield, Pamela A, Burton, Catherine R, Cox, Sarah, Doleniak, Deborah, Seitz, Steven P
Published in Journal of medicinal chemistry (21.11.2002)
Published in Journal of medicinal chemistry (21.11.2002)
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Efficient Synthesis of 5-(Bromomethyl)- and 5-(Aminomethyl)-1-THP-Indazole
Sun, Jung-Hui, Teleha, Christopher A, Yan, Jia-Sheng, Rodgers, James D, Nugiel, David A
Published in Journal of organic chemistry (08.08.1997)
Published in Journal of organic chemistry (08.08.1997)
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Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3
Yue, Eddy W, Higley, C. Anne, DiMeo, Susan V, Carini, David J, Nugiel, David A, Benware, Carrie, Benfield, Pamela A, Burton, Catherine R, Cox, Sarah, Grafstrom, Robert H, Sharp, Diane M, Sisk, Lisa M, Boylan, John F, Muckelbauer, Jodi K, Smallwood, Angela M, Chen, Haiying, Chang, Chong-Hwan, Seitz, Steven P, Trainor, George L
Published in Journal of medicinal chemistry (21.11.2002)
Published in Journal of medicinal chemistry (21.11.2002)
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De Novo Design of a Picomolar Nonbasic 5-HT1B Receptor Antagonist
Nugiel, David A, Krumrine, Jennifer R, Hill, Daniel C, Damewood, James R, Bernstein, Peter R, Sobotka-Briner, Cynthia D, Liu, JianWei, Zacco, Anna, Pierson, M. Edward
Published in Journal of medicinal chemistry (25.02.2010)
Published in Journal of medicinal chemistry (25.02.2010)
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Azepines and Piperidines with Dual Norepinephrine Dopamine Uptake Inhibition and Antidepressant Activity
Brown, Dean G, Bernstein, Peter R, Wu, Ye, Urbanek, Rebecca A, Becker, Christopher W, Throner, Scott R, Dembofsky, Bruce T, Steelman, Gary B, Lazor, Lois A, Scott, Clay W, Wood, Michael W, Wesolowski, Steven S, Nugiel, David A, Koch, Stephanie, Yu, Jian, Pivonka, Donald E, Li, Shuang, Thompson, Carol, Zacco, Anna, Elmore, Charles S, Schroeder, Patricia, Liu, JianWei, Hurley, Christopher A, Ward, Stuart, Hunt, Hazel J, Williams, Karen, McLaughlin, Joseph, Hoesch, Valerie, Sydserff, Simon, Maier, Donna, Aharony, David
Published in ACS medicinal chemistry letters (10.01.2013)
Published in ACS medicinal chemistry letters (10.01.2013)
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Indenopyrazoles as Novel Cyclin Dependent Kinase (CDK) Inhibitors
Nugiel, David A, Etzkorn, Ana-Marie, Vidwans, Anup, Benfield, Pamela A, Boisclair, Michael, Burton, Catherine R, Cox, Sarah, Czerniak, Phillip M, Doleniak, Deborah, Seitz, Steven P
Published in Journal of medicinal chemistry (26.04.2001)
Published in Journal of medicinal chemistry (26.04.2001)
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Facile Preparation of 2,6-Disubstituted Purines Using Solid-Phase Chemistry
Nugiel, David A, Cornelius, Lyndon A. M, Corbett, Jeffrey W
Published in Journal of organic chemistry (10.01.1997)
Published in Journal of organic chemistry (10.01.1997)
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Preparation and Structure−Activity Relationship of Novel P1/P1‘-Substituted Cyclic Urea-Based Human Immunodeficiency Virus Type-1 Protease Inhibitors
Nugiel, David A, Jacobs, Kim, Worley, Tabitha, Patel, Mona, Kaltenbach, Robert F, Meyer, Dayton T, Jadhav, Prabhakar K, De Lucca, George V, Smyser, Thomas E, Klabe, Ronald M, Bacheler, Lee T, Rayner, Marlene M, Seitz, Steven P
Published in Journal of medicinal chemistry (24.05.1996)
Published in Journal of medicinal chemistry (24.05.1996)
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Improved P1/P1‘ Substituents for Cyclic Urea Based HIV-1 Protease Inhibitors: Synthesis, Structure−Activity Relationship, and X-ray Crystal Structure Analysis
Nugiel, David A, Jacobs, Kim, Cornelius, Lyndon, Chang, Chong-Hwan, Jadhav, Prabhakar K, Holler, Edward R, Klabe, Ronald M, Bacheler, Lee T, Cordova, Beverly, Garber, Sena, Reid, Carol, Logue, Kelly A, Gorey-Feret, Lorraine J, Lam, Gilbert N, Erickson-Viitanen, Susan, Seitz, Steven P
Published in Journal of medicinal chemistry (09.05.1997)
Published in Journal of medicinal chemistry (09.05.1997)
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Stable simple enols. 23. Solid-state structures of 1-alkyl-2,2-dimesitylethenols. Application of the principle of structural correlation to ring-flip processes in 1,1-diarylvinyl systems
Kaftory, Menahem, Nugiel, David A, Biali, Silvio E, Rappoport, Zvi
Published in Journal of the American Chemical Society (01.10.1989)
Published in Journal of the American Chemical Society (01.10.1989)
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Journal Article
Association of .alpha.-alkyl-.beta.,.beta.-dimesitylethenols with hydrogen-bond-accepting solvents
Rappoport, Zvi, Nugiel, David A, Biali, Silvio E
Published in Journal of organic chemistry (01.09.1988)
Published in Journal of organic chemistry (01.09.1988)
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