Structure-guided inhibitor design for human FAAH by interspecies active site conversion
Mileni, Mauro, Johnson, Douglas S, Wang, Zhigang, Everdeen, Daniel S, Liimatta, Marya, Pabst, Brandon, Bhattacharya, Keshab, Nugent, Richard A, Kamtekar, Satwik, Cravatt, Benjamin F, Ahn, Kay, Stevens, Raymond C
Published in Proceedings of the National Academy of Sciences - PNAS (02.09.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (02.09.2008)
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3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 1. Lead Finding
Pevarello, Paolo, Brasca, Maria Gabriella, Amici, Raffaella, Orsini, Paolo, Traquandi, Gabriella, Corti, Luca, Piutti, Claudia, Sansonna, Pietro, Villa, Manuela, Pierce, Betsy S, Pulici, Maurizio, Giordano, Patrizia, Martina, Katia, Fritzen, Edward L, Nugent, Richard A, Casale, Elena, Cameron, Alexander, Ciomei, Marina, Roletto, Fulvia, Isacchi, Antonella, Fogliatto, GianPaolo, Pesenti, Enrico, Pastori, Wilma, Marsiglio, Aurelio, Leach, Karen L, Clare, Paula M, Fiorentini, Francesco, Varasi, Mario, Vulpetti, Anna, Warpehoski, Martha A
Published in Journal of medicinal chemistry (17.06.2004)
Published in Journal of medicinal chemistry (17.06.2004)
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Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders
Gurney, Mark E, Nugent, Richard A, Mo, Xuesheng, Sindac, Janice A, Hagen, Timothy J, Fox, David, O’Donnell, James M, Zhang, Chong, Xu, Ying, Zhang, Han-Ting, Groppi, Vincent E, Bailie, Marc, White, Ronald E, Romero, Donna L, Vellekoop, A. Samuel, Walker, Joel R, Surman, Matthew D, Zhu, Lei, Campbell, Robert F
Published in Journal of medicinal chemistry (23.05.2019)
Published in Journal of medicinal chemistry (23.05.2019)
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Novel Mechanistic Class of Fatty Acid Amide Hydrolase Inhibitors with Remarkable Selectivity
Ahn, Kyunghye, Johnson, Douglas S, Fitzgerald, Laura R, Liimatta, Marya, Arendse, Andrea, Stevenson, Tracy, Lund, Eric. T, Nugent, Richard A, Nomanbhoy, Tyzoon K, Alexander, Jessica P, Cravatt, Benjamin F
Published in Biochemistry (Easton) (13.11.2007)
Published in Biochemistry (Easton) (13.11.2007)
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Discovery, Radiolabeling, and Evaluation of Subtype-Selective Inhibitors for Positron Emission Tomography Imaging of Brain Phosphodiesterase-4D
Wakabayashi, Yuichi, Telu, Sanjay, Dick, Rachel M, Fujita, Masahiro, Ooms, Maarten, Morse, Cheryl L, Liow, Jeih-San, Hong, Jinsoo S, Gladding, Robert L, Manly, Lester S, Zoghbi, Sami S, Mo, Xuesheng, D’Amato, Emily C, Sindac, Janice A, Nugent, Richard A, Marron, Brian E, Gurney, Mark E, Innis, Robert B, Pike, Victor W
Published in ACS chemical neuroscience (06.05.2020)
Published in ACS chemical neuroscience (06.05.2020)
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Novel benzoxazole inhibitors of mPGES-1
Kablaoui, Natasha, Patel, Snahel, Shao, Jay, Demian, Douglas, Hoffmaster, Keith, Berlioz, Francioise, Vazquez, Michael L., Moore, William M., Nugent, Richard A.
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility
Nieman, James A., Nair, Sajiv K., Heasley, Steven E., Schultz, Brenda L., Zerth, Herbert M., Nugent, Richard A., Chen, Ke, Stephanski, Kevin J., Hopkins, Todd A., Knechtel, Mary L., Oien, Nancee L., Wieber, Janet L., Wathen, Michael W.
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid
Pfefferkorn, Jeffrey A., Greene, Meredith L., Nugent, Richard A., Gross, Rebecca J., Mitchell, Mark A., Finzel, Barry C., Harris, Melissa S., Wells, Peter A., Shelly, John A., Anstadt, Robert A., Kilkuskie, Robert E., Kopta, Laurice A., Schwende, Francis J.
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
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Carbonyl-Containing Bisphosphonate Esters as Novel Antiinflammatory and Antiarthritic Agents
Nugent, Richard A, Schlachter, Stephen T, Murphy, Megan, Dunn, Colin J, Staite, Nigel D, Galinet, Louise A, Shields, Sharon K, Wu, Haiyan, Aspar, Danielle G, Richard, Karen A
Published in Journal of medicinal chemistry (01.12.1994)
Published in Journal of medicinal chemistry (01.12.1994)
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(−)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor
Wishka, Donn G, Graber, David R, Kopta, Laurice A, Olmsted, Robert A, Friis, Janice M, Hosley, John D, Adams, Wade J, Seest, Eric P, Castle, Thomas M, Dolak, Lester A, Keiser, Barbara J, Yagi, Yoshihiko, Jeganathan, Azhwarsamy, Schlachter, Stephen T, Murphy, Michael J, Cleek, Gary J, Nugent, Richard A, Poppe, Susan M, Swaney, Steven M, Han, Fusen, Watt, William, White, Wendy L, Poel, Toni-Jo, Thomas, Richard C, Voorman, Richard L, Stefanski, Kevin J, Stehle, Randall G, Tarpley, W. Gary, Morris, Joel
Published in Journal of medicinal chemistry (23.04.1998)
Published in Journal of medicinal chemistry (23.04.1998)
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PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
BARSUKOV YEVGEN, NUGENT RICHARD A, COLE BRIDGET M, HANDLEY KAREN, KOLODZIEJ ANDREW
Year of Publication 04.11.2015
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Year of Publication 04.11.2015
Patent
Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV
Nugent, Richard A, Schlachter, Stephen T, Murphy, Michael J, Cleek, Gary J, Poel, Toni J, Wishka, Donn G, Graber, David R, Yagi, Yoshihiko, Keiser, Barbara J, Olmsted, Robert A, Kopta, Laurie A, Swaney, Steven M, Poppe, Susan M, Morris, Joel, Tarpley, W. Gary, Thomas, Richard C
Published in Journal of medicinal chemistry (24.09.1998)
Published in Journal of medicinal chemistry (24.09.1998)
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Journal Article
Pyrazoline bisphosphonate esters as novel antiinflammatory and antiarthritic agents
Nugent, Richard A., Murphy, Megan, Schlachter, Stephen T., Dunn, Colin J., Smith, Robert J., Staite, Nigel D., Galinet, Louise A., Shields, Sharon K., Aspar, Danielle G., Richard, Karen A., Rohloff, Norman A.
Published in Journal of medicinal chemistry (1993)
Published in Journal of medicinal chemistry (1993)
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Tetraalkyl oxiranylidenebis(phosphonates). Synthesis and reactions with nucleophiles
Burgos-Lepley, Carmen E, Mizsak, Stephen A, Nugent, Richard A, Johnson, Roy A
Published in Journal of organic chemistry (01.07.1993)
Published in Journal of organic chemistry (01.07.1993)
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