Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice
Ullman, Julie C, Arguello, Annie, Getz, Jennifer A, Bhalla, Akhil, Mahon, Cathal S, Wang, Junhua, Giese, Tina, Bedard, Catherine, Kim, Do Jin, Blumenfeld, Jessica R, Liang, Nicholas, Ravi, Ritesh, Nugent, Alicia A, Davis, Sonnet S, Ha, Connie, Duque, Joseph, Tran, Hai L, Wells, Robert C, Lianoglou, Steve, Daryani, Vinay M, Kwan, Wanda, Solanoy, Hilda, Nguyen, Hoang, Earr, Timothy, Dugas, Jason C, Tuck, Michael D, Harvey, Jennifer L, Reyzer, Michelle L, Caprioli, Richard M, Hall, Sejal, Poda, Suresh, Sanchez, Pascal E, Dennis, Mark S, Gunasekaran, Kannan, Srivastava, Ankita, Sandmann, Thomas, Henne, Kirk R, Thorne, Robert G, Di Paolo, Gilbert, Astarita, Giuseppe, Diaz, Dolores, Silverman, Adam P, Watts, Ryan J, Sweeney, Zachary K, Kariolis, Mihalis S, Henry, Anastasia G
Published in Science translational medicine (27.05.2020)
Published in Science translational medicine (27.05.2020)
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Human CFEOM1 Mutations Attenuate KIF21A Autoinhibition and Cause Oculomotor Axon Stalling
Cheng, Long, Desai, Jigar, Miranda, Carlos J., Duncan, Jeremy S., Qiu, Weihong, Nugent, Alicia A., Kolpak, Adrianne L., Wu, Carrie C., Drokhlyansky, Eugene, Delisle, Michelle M., Chan, Wai-Man, Wei, Yan, Propst, Friedrich, Reck-Peterson, Samara L., Fritzsch, Bernd, Engle, Elizabeth C.
Published in Neuron (Cambridge, Mass.) (16.04.2014)
Published in Neuron (Cambridge, Mass.) (16.04.2014)
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Loss of MAFB Function in Humans and Mice Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects
Park, Jong G., Tischfield, Max A., Nugent, Alicia A., Cheng, Long, Di Gioia, Silvio Alessandro, Chan, Wai-Man, Maconachie, Gail, Bosley, Thomas M., Summers, C. Gail, Hunter, David G., Robson, Caroline D., Gottlob, Irene, Engle, Elizabeth C.
Published in American journal of human genetics (02.06.2016)
Published in American journal of human genetics (02.06.2016)
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TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
Nugent, Alicia A., Lin, Karin, van Lengerich, Bettina, Lianoglou, Steve, Przybyla, Laralynne, Davis, Sonnet S., Llapashtica, Ceyda, Wang, Junhua, Kim, Do Jin, Xia, Dan, Lucas, Anthony, Baskaran, Sulochanadevi, Haddick, Patrick C.G., Lenser, Melina, Earr, Timothy K., Shi, Ju, Dugas, Jason C., Andreone, Benjamin J., Logan, Todd, Solanoy, Hilda O., Chen, Hang, Srivastava, Ankita, Poda, Suresh B., Sanchez, Pascal E., Watts, Ryan J., Sandmann, Thomas, Astarita, Giuseppe, Lewcock, Joseph W., Monroe, Kathryn M., Di Paolo, Gilbert
Published in Neuron (Cambridge, Mass.) (04.03.2020)
Published in Neuron (Cambridge, Mass.) (04.03.2020)
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Human disorders of axon guidance
Nugent, Alicia A, Kolpak, Adrianne L, Engle, Elizabeth C
Published in Current opinion in neurobiology (01.10.2012)
Published in Current opinion in neurobiology (01.10.2012)
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Neutral or Detrimental Effects of TREM2 Agonist Antibodies in Preclinical Models of Alzheimer’s Disease and Multiple Sclerosis
Etxeberria, Ainhoa, Shen, Yun-An A., Vito, Stephen, Silverman, Sean M., Imperio, Jose, Lalehzadeh, Guita, Soung, Allison L., Du, Changchun, Xie, Luke, Choy, Man Kin, Hsiao, Yi-chun, Ngu, Hai, Cho, Chang Hoon, Ghosh, Soumitra, Novikova, Gloriia, Rezzonico, Mitchell G., Leahey, Rebecca, Weber, Martin, Gogineni, Alvin, Elstrott, Justin, Xiong, Monica, Greene, Jacob J., Stark, Kimberly L., Chan, Pamela, Roth, Gillie A., Adrian, Max, Li, Qingling, Choi, Meena, Wong, Weng Ruh, Sandoval, Wendy, Foreman, Oded, Nugent, Alicia A., Friedman, Brad A., Sadekar, Shraddha, Hötzel, Isidro, Hansen, David V., Chih, Ben, Yuen, Tracy J., Weimer, Robby M., Easton, Amy, Meilandt, William J., Bohlen, Christopher J.
Published in The Journal of neuroscience (17.07.2024)
Published in The Journal of neuroscience (17.07.2024)
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Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome
Nugent, Alicia A, Park, Jong G, Wei, Yan, Tenney, Alan P, Gilette, Nicole M, DeLisle, Michelle M, Chan, Wai-Man, Cheng, Long, Engle, Elizabeth C
Published in The Journal of clinical investigation (01.05.2017)
Published in The Journal of clinical investigation (01.05.2017)
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Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome
Nugent, Alicia A., Park, Jong G., Wei, Yan, Tenney, Alan P., Gilette, Nicole M., DeLisle, Michelle M., Chan, Wai-Man, Cheng, Long, Engle, Elizabeth C.
Published in The Journal of clinical investigation (01.05.2017)
Published in The Journal of clinical investigation (01.05.2017)
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DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response
Yulyaningsih, Ernie, Suh, Jung H, Fanok, Melania, Chau, Roni, Solanoy, Hilda, Takahashi, Ryan, Bakardjiev, Anna I, Becerra, Isabel, Benitez, N Butch, Chiu, Chi-Lu, Davis, Sonnet S, Dowdle, William E, Earr, Timothy, Estrada, Anthony A, Gill, Audrey, Ha, Connie, Haddick, Patrick CG, Henne, Kirk R, Larhammar, Martin, Leung, Amy W-S, Maciuca, Romeo, Memarzadeh, Bahram, Nguyen, Hoang N, Nugent, Alicia A, Osipov, Maksim, Ran, Yingqing, Rebadulla, Kevin, Roche, Elysia, Sandman, Thomas, Wang, Jing, Lewcock, Joseph W, Scearce-Levie, Kimberly, Kane, Lesley A, Sanchez, Pascal E
Published in eLife (17.09.2024)
Published in eLife (17.09.2024)
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Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism
Schauer, Stephen P., Cho, Chang Hoon, Novikova, Gloriia, Roth, Gillie A., Lee, Julie, Sharma, Anup D., Foley, Alejandro R., Ng, Carl, Shen, Philip, Choi, Meena, Ma, Taylur P., Phu, Lilian, Budayeva, Hanna G., Cheung, Tommy K., Lalehzadeh, Guita, Imperio, Jose, Ngu, Hai, Etxeberria, Ainhoa, Liang, Yuxin, Rezzonico, Mitchell G., Dourado, Michelle, Huang, Kevin, Lai, Zijuan, Hokom, Martha, Pandya, Nikhil J., Newton, Dwight, Abdel‐Haleem, Alyaa M., Chan, Pamela, Lee, Donna, Tassew, Nardos G., Sangaraju, Dewakar, O'Connor, Deborah, Hötzel, Isidro, Stark, Kimberly L., Chou, Carolina, Foreman, Oded, Easton, Amy, Wildsmith, Kristin R., Sperinde, Gizette, Rose, Christopher M., Friedman, Brad A., Fuji, Reina N., Weimer, Robby M., Meilandt, William J., Sadekar, Shraddha, Nugent, Alicia A., Biever, Anne
Published in Alzheimer's & dementia (01.08.2024)
Published in Alzheimer's & dementia (01.08.2024)
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Novel FACS based method demonstrates CNS cell-type distribution and efficacy of a BBB penetrant ERT in a mouse model of MPS II
Ullman, Julie C., Nugent, Alicia A., Arguello, Annie, Bhalla, Akhil, Sandmann, Thomas, Lianoglou, Steve, Ha, Connie, Wang, Junhua, Davis, Sonnet S., Alkabsh, Jamal, Astarita, Giuseppe, Di Paolo, Gilbert, Giese, Tina, Mahon, Cathal, Bedard, Catherine, Liang, Nicholas, Kannan, Gunasekaran, Lewcock, Joesph W., Sweeney, Zachary K., Kariolis, Mihalis S., Diaz, Dolo, Henry, Anastasia
Published in Molecular genetics and metabolism (01.02.2020)
Published in Molecular genetics and metabolism (01.02.2020)
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METHODS FOR TREATING DYSREGULATED LIPID METABOLISM
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Year of Publication 27.04.2023
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Year of Publication 27.04.2023
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METHODS FOR TREATING DYSREGULATED LIPID METABOLISM
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Year of Publication 27.01.2022
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Year of Publication 27.01.2022
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METHODS FOR TREATING DYSREGULATED LIPID METABOLISM
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Year of Publication 06.10.2021
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Year of Publication 06.10.2021
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PROCÉDÉS DE TRAITEMENT DU MÉTABOLISME LIPIDIQUE DÉRÉGULÉ
NUGENT, Alicia A, VAN LENGERICH, Bettina, ASTARITA, Giuseppe, DI PAOLO, Gilbert, LIN, Kai Lin, MONROE, Kathryn M
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METHODS FOR TREATING DYSREGULATED LIPID METABOLISM
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Year of Publication 10.06.2021
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LYSOSOMAL STORAGE DISORDER BIOMARKERS AND METHODS OF USE THEREOF
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Year of Publication 27.01.2022
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Year of Publication 27.01.2022
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LYSOSOMAL STORAGE DISORDER BIOMARKERS AND METHODS OF USE THEREOF
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Year of Publication 20.10.2021
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Year of Publication 20.10.2021
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BIOMARQUEURS DE MALADIE LYSOSOMALE ET LEURS MÉTHODES D'UTILISATION
NUGENT, Alicia A, ASTARITA, Giuseppe, WANG, Junhua, DI PAOLO, Gilbert, ARGUELLO, Annie, BHALLA, Akhil, HENRY, Anastasia, ULLMAN, Julie, BLUMENFELD, Jessica R
Year of Publication 20.10.2021
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Year of Publication 20.10.2021
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METHODS FOR TREATING DYSREGULATED LIPID METABOLISM
NUGENT, Alicia A, VAN LENGERICH, Bettina, ASTARITA, Giuseppe, DI PAOLO, Gilbert, LIN, Kai Lin, MONROE, Kathryn M
Year of Publication 30.07.2020
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Year of Publication 30.07.2020
Patent