Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS‐790052 in Humans: In Vitro and In Vivo Correlations
Fridell, Robert A., Wang, Chunfu, Sun, Jin‐Hua, O'Boyle, Donald R., Nower, Peter, Valera, Lourdes, Qiu, Dike, Roberts, Susan, Huang, Xin, Kienzle, Bernadette, Bifano, Marc, Nettles, Richard E., Gao, Min
Published in Hepatology (Baltimore, Md.) (01.12.2011)
Published in Hepatology (Baltimore, Md.) (01.12.2011)
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Identification of Hepatitis C Virus NS5A Inhibitors
LEMM, Julie A, O'BOYLE, Donald, ROMINE, Jeffrey L, MEANWELL, Nicholas A, MIN GAO, MENGPING LIU, NOWER, Peter T, COLONNO, Richard, DESHPANDE, Milind S, SNYDER, Lawrence B, MARTIN, Scott W, LAURENT, Denis R. St, SERRANO-WU, Michael H
Published in Journal of Virology (01.01.2010)
Published in Journal of Virology (01.01.2010)
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Persistence of Resistant Variants in Hepatitis C Virus-Infected Patients Treated with the NS5A Replication Complex Inhibitor Daclatasvir
CHUNFU WANG, SUN, Jin-Hua, O'BOYLE, Donald R, NOWER, Peter, VALERA, Lourdes, ROBERTS, Susan, FRIDELL, Robert A, MIN GAO
Published in Antimicrobial Agents and Chemotherapy (01.05.2013)
Published in Antimicrobial Agents and Chemotherapy (01.05.2013)
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Hepatitis C Virus RNA Elimination and Development of Resistance in Replicon Cells Treated with BMS-790052
Wang, Chunfu, Huang, Haichang, Valera, Lourdes, Sun, Jin-Hua, O'Boyle, Donald R., II, Nower, Peter T, Jia, Lingling, Qiu, Dike, Huang, Xin, Altaf, Aneela, Gao, Min, Fridell, Robert A
Published in Antimicrobial Agents and Chemotherapy (01.03.2012)
Published in Antimicrobial Agents and Chemotherapy (01.03.2012)
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Comparison of daclatasvir resistance barriers on NS5A from hepatitis C virus genotypes 1 to 6: implications for cross-genotype activity
Wang, Chunfu, Jia, Lingling, O'Boyle, 2nd, Donald R, Sun, Jin-Hua, Rigat, Karen, Valera, Lourdes, Nower, Peter, Huang, Xin, Kienzle, Bernadette, Roberts, Susan, Gao, Min, Fridell, Robert A
Published in Antimicrobial agents and chemotherapy (01.09.2014)
Published in Antimicrobial agents and chemotherapy (01.09.2014)
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In Vitro Activity of BMS-790052 on Hepatitis C Virus Genotype 4 NS5A
Wang, Chunfu, Jia, Lingling, Huang, Haichang, Qiu, Dike, Valera, Lourdes, Huang, Xin, Sun, Jin-Hua, Nower, Peter T, O'Boyle, 2nd, Donald R, Gao, Min, Fridell, Robert A
Published in Antimicrobial Agents and Chemotherapy (01.03.2012)
Published in Antimicrobial Agents and Chemotherapy (01.03.2012)
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effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization
Qiu, Dike, Lemm, Julie A, O’Boyle, Donald R., II, Sun, Jin-Hua, Nower, Peter T, Nguyen, Van, Hamann, Lawrence G, Snyder, Lawrence B, Deon, Daniel H, Ruediger, Edward, Meanwell, Nicholas A, Belema, Makonen, Gao, Min, Fridell, Robert A
Published in Journal of general virology (01.11.2011)
Published in Journal of general virology (01.11.2011)
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Characterizations of HCV NS5A replication complex inhibitors
O'Boyle II, Donald R, Sun, Jin-Hua, Nower, Peter T, Lemm, Julie A, Fridell, Robert A, Wang, Chunfu, Romine, Jeffrey L, Belema, Makonen, Nguyen, Van N, Laurent, Denis R. St, Serrano-Wu, Michael, Snyder, Lawrence B, Meanwell, Nicholas A, Langley, David R, Gao, Min
Published in Virology (New York, N.Y.) (01.09.2013)
Published in Virology (New York, N.Y.) (01.09.2013)
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Discovery of Potent Hepatitis C Virus NS5A Inhibitors with Dimeric Structures
Lemm, Julie A, Leet, John E, O'Boyle, 2nd, Donald R, Romine, Jeffrey L, Huang, Xiaohua Stella, Schroeder, Daniel R, Alberts, Jeffrey, Cantone, Joseph L, Sun, Jin-Hua, Nower, Peter T, Martin, Scott W, Serrano-Wu, Michael H, Meanwell, Nicholas A, Snyder, Lawrence B, Gao, Min
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
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Impact of a baseline polymorphism on the emergence of resistance to the hepatitis C virus nonstructural protein 5a replication complex inhibitor, BMS-790052
Sun, Jin-Hua, O'Boyle II, Donald R., Zhang, Yan, Wang, Chunfu, Nower, Peter, Valera, Lourdes, Roberts, Susan, Nettles, Richard E., Fridell, Robert A., Gao, Min
Published in Hepatology (Baltimore, Md.) (01.06.2012)
Published in Hepatology (Baltimore, Md.) (01.06.2012)
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Synergistic Activity of Combined NS5A Inhibitors
O'Boyle, 2nd, Donald R, Nower, Peter T, Gao, Min, Fridell, Robert, Wang, Chunfu, Hewawasam, Piyasena, Lopez, Omar, Tu, Yong, Meanwell, Nicholas A, Belema, Makonen, Roberts, Susan B, Cockett, Mark, Sun, Jin-Hua
Published in Antimicrobial agents and chemotherapy (01.03.2016)
Published in Antimicrobial agents and chemotherapy (01.03.2016)
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Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons
Belema, Makonen, Nguyen, Van N., Romine, Jeffrey L., St. Laurent, Denis R., Lopez, Omar D., Goodrich, Jason T., Nower, Peter T., O’Boyle, Donald R., Lemm, Julie A., Fridell, Robert A., Gao, Min, Fang, Hua, Krause, Rudolph G., Wang, Ying-Kai, Oliver, A. Jayne, Good, Andrew C., Knipe, Jay O., Meanwell, Nicholas A., Snyder, Lawrence B.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes
Romine, Jeffrey L, St. Laurent, Denis R, Leet, John E, Martin, Scott W, Serrano-Wu, Michael H, Yang, Fukang, Gao, Min, O’Boyle, Donald R, Lemm, Julie A, Sun, Jin-Hua, Nower, Peter T, Huang, Xiaohua (Stella), Deshpande, Milind S, Meanwell, Nicholas A, Snyder, Lawrence B
Published in ACS medicinal chemistry letters (10.03.2011)
Published in ACS medicinal chemistry letters (10.03.2011)
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HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies
Lopez, Omar D, Nguyen, Van N, St. Laurent, Denis R, Belema, Makonen, Serrano-Wu, Michael H, Goodrich, Jason T, Yang, Fukang, Qiu, Yuping, Ripka, Amy S, Nower, Peter T, Valera, Lourdes, Liu, Mengping, O’Boyle, Donald R., II, Sun, Jin-Hua, Fridell, Robert A, Lemm, Julie A, Gao, Min, Good, Andrew C, Meanwell, Nicholas A, Snyder, Lawrence B
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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HCV NS5A replication complex inhibitors. Part 5: Discovery of potent and pan-genotypic glycinamide cap derivatives
Belema, Makonen, Nguyen, Van N., St. Laurent, Denis R., Lopez, Omar D., Qiu, Yuping, Good, Andrew C., Nower, Peter T., Valera, Lourdes, O’Boyle, Donald R., Sun, Jin-Hua, Liu, Mengping, Fridell, Robert A., Lemm, Julie A., Gao, Min, Knipe, Jay O., Meanwell, Nicholas A., Snyder, Lawrence B.
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
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HCV NS5A replication complex inhibitors. Part 2: Investigation of stilbene prolinamides
St. Laurent, Denis R., Belema, Makonen, Gao, Min, Goodrich, Jason, Kakarla, Ramesh, Knipe, Jay O., Lemm, Julie A., Liu, Mengping, Lopez, Omar D., Nguyen, Van N., Nower, Peter T., O’Boyle, Donald, Qiu, Yuping, Romine, Jeffrey L., Serrano-Wu, Michael H., Sun, Jin-Hua, Valera, Lourdes, Yang, Fukang, Yang, Xuejie, Meanwell, Nicholas A., Snyder, Lawrence B.
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
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A 96-well based analysis of replicon elimination with the HCV NS5A replication complex inhibitor daclatasvir
O’Boyle, Donald R., Nower, Peter T., Sun, Jin-Hua, Fridell, Robert, Wang, Chunfu, Valera, Lourdes, Gao, Min
Published in Journal of virological methods (01.10.2013)
Published in Journal of virological methods (01.10.2013)
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Development of a Cell-Based High-Throughput Specificity Screen Using a Hepatitis C Virus-Bovine Viral Diarrhea Virus Dual Replicon Assay
O'BOYLE, Donald R, NOWER, Peter T, LEMM, Julie A, VALERA, Lourdes, SUN, Jin-Hua, RIGAT, Karen, COLONNO, Richard, MIN GAO
Published in Antimicrobial Agents and Chemotherapy (01.04.2005)
Published in Antimicrobial Agents and Chemotherapy (01.04.2005)
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HCV NS5A Replication Complex Inhibitors. Part 4. Optimization for Genotype 1a Replicon Inhibitory Activity
St. Laurent, Denis R., Serrano-Wu, Michael H., Belema, Makonen, Ding, Min, Fang, Hua, Gao, Min, Goodrich, Jason T., Krause, Rudolph G., Lemm, Julie A., Liu, Mengping, Lopez, Omar D., Nguyen, Van N., Nower, Peter T., O’Boyle, Donald R., Pearce, Bradley C., Romine, Jeffrey L., Valera, Lourdes, Sun, Jin-Hua, Wang, Ying-Kai, Yang, Fukang, Yang, Xuejie, Meanwell, Nicholas A., Snyder, Lawrence B.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A
Sun, Jin-Hua, O’Boyle II, Donald R., Fridell, Robert A., Langley, David R., Wang, Chunfu, Roberts, Susan B., Nower, Peter, Johnson, Benjamin M., Moulin, Frederic, Nophsker, Michelle J., Wang, Ying-Kai, Liu, Mengping, Rigat, Karen, Tu, Yong, Hewawasam, Piyasena, Kadow, John, Meanwell, Nicholas A., Cockett, Mark, Lemm, Julie A., Kramer, Melissa, Belema, Makonen, Gao, Min
Published in Nature (London) (12.11.2015)
Published in Nature (London) (12.11.2015)
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