A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma
Fan, QiWen, Aksoy, Ozlem, Wong, Robyn A., Ilkhanizadeh, Shirin, Novotny, Chris J., Gustafson, William C., Truong, Albert Yi-Que, Cayanan, Geraldine, Simonds, Erin F., Haas-Kogan, Daphne, Phillips, Joanna J., Nicolaides, Theodore, Okaniwa, Masanori, Shokat, Kevan M., Weiss, William A.
Published in Cancer cell (13.03.2017)
Published in Cancer cell (13.03.2017)
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Journal Article
Discovery and Canine Preclinical Assessment of a Nontoxic Procaspase-3―Activating Compound
PETERSON, Quinn P, HSU, Danny C, NOVOTNY, Chris J, WEST, Diana C, KIM, Dewey, SCHMIT, Joanna M, DIRIKOLU, Levent, HERGENROTHER, Paul J, FAN, Timothy M
Published in Cancer research (Chicago, Ill.) (15.09.2010)
Published in Cancer research (Chicago, Ill.) (15.09.2010)
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Journal Article
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
Rodrik-Outmezguine, Vanessa S, Okaniwa, Masanori, Yao, Zhan, Novotny, Chris J, McWhirter, Claire, Banaji, Arpitha, Won, Helen, Wong, Wai, Berger, Mike, de Stanchina, Elisa, Barratt, Derek G, Cosulich, Sabina, Klinowska, Teresa, Rosen, Neal, Shokat, Kevan M
Published in Nature (London) (09.06.2016)
Published in Nature (London) (09.06.2016)
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Journal Article
Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors
Lazarus, Michael B, Novotny, Chris J, Shokat, Kevan M
Published in ACS chemical biology (16.01.2015)
Published in ACS chemical biology (16.01.2015)
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Journal Article
Dissecting the biology of mTORC1 beyond rapamycin
Yang, Guang, Francis, Deanne, Krycer, James R, Larance, Mark, Zhang, Ziyang, Novotny, Chris J, Diaz-Vegas, Alexis, Shokat, Kevan M, James, David E
Published in Science signaling (21.09.2021)
Published in Science signaling (21.09.2021)
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Journal Article
Overcoming resistance to HER2 inhibitors through state-specific kinase binding
Novotny, Chris J, Pollari, Sirkku, Park, Jin H, Lemmon, Mark A, Shen, Weijun, Shokat, Kevan M
Published in Nature chemical biology (01.11.2016)
Published in Nature chemical biology (01.11.2016)
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Journal Article
Procaspase-3 Activation as an Anti-Cancer Strategy: Structure−Activity Relationship of Procaspase-Activating Compound 1 (PAC-1) and Its Cellular Co-Localization with Caspase-3
Peterson, Quinn P., Hsu, Danny C., Goode, David R., Novotny, Chris J., Totten, Ryan K., Hergenrother, Paul J.
Published in Journal of medicinal chemistry (24.09.2009)
Published in Journal of medicinal chemistry (24.09.2009)
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Journal Article
Parallel Synthesis and Biological Evaluation of 837 Analogues of Procaspase-Activating Compound 1 (PAC-1)
Hsu, Danny C, Roth, Howard S, West, Diana C, Botham, Rachel C, Novotny, Chris J, Schmid, Steven C, Hergenrother, Paul J
Published in ACS combinatorial science (09.01.2012)
Published in ACS combinatorial science (09.01.2012)
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Journal Article
Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs
Lucas, Pamela W., Schmit, Joanna M., Peterson, Quinn P., West, Diana C., Hsu, Danny C., Novotny, Chris J., Dirikolu, Levent, Churchwell, Mona I., Doerge, Daniel R., Garrett, Laura D., Hergenrother, Paul J., Fan, Timothy M.
Published in Investigational new drugs (01.10.2011)
Published in Investigational new drugs (01.10.2011)
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Journal Article
Discovery and Canine Preclinical Assessment of a Non-Toxic Procaspase-3-Activating Compound
Peterson, Quinn P., Hsu, Danny C., Novotny, Chris J., West, Diana C., Kim, Dewey, Schmit, Joanna M., Dirikolu, Levent, Hergenrother, Paul J., Fan, Timothy M.
Published in Cancer research (Chicago, Ill.) (07.09.2010)
Published in Cancer research (Chicago, Ill.) (07.09.2010)
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Journal Article
Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1 in healthy dogs
Lucas, Pamela W., Schmit, Joanna M., Peterson, Quinn P., West, Diana C., Hsu, Danny C., Novotny, Chris J., Dirikolu, Levent, Deorge, Daniel R., Garrett, Laura D., Hergenrother, Paul J., Fan, Timothy M.
Published in Investigational new drugs (25.05.2010)
Published in Investigational new drugs (25.05.2010)
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Journal Article
Procaspase activating compounds
Hergenrother Paul J, Fan Timothy M, West Diana C, Peterson Quinn Patrick, Novotny Chris J, Hsu Danny Chung
Year of Publication 09.05.2017
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Year of Publication 09.05.2017
Patent
PROCASPASE ACTIVATING COMPOUNDS
FAN TIMOTHY M, HERGENROTHER PAUL J, PETERSON QUINN PATRICK, WEST DIANA C, NOVOTNY CHRIS J, HSU DANNY CHUNG
Year of Publication 03.12.2015
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Year of Publication 03.12.2015
Patent