4-Hydroxy-5,6-dihydropyrones as Inhibitors of HIV Protease: The Effect of Heterocyclic Substituents at C-6 on Antiviral Potency and Pharmacokinetic Parameters
Hagen, Susan E, Domagala, John, Gajda, Christopher, Lovdahl, Michael, Tait, Bradley D, Wise, Eric, Holler, Tod, Hupe, Donald, Nouhan, Carolyn, Urumov, Andrej, Zeikus, Greg, Zeikus, Eric, Lunney, Elizabeth A, Pavlovsky, Alexander, Gracheck, Stephen J, Saunders, James, VanderRoest, Steve, Brodfuehrer, Joanne
Published in Journal of medicinal chemistry (05.07.2001)
Published in Journal of medicinal chemistry (05.07.2001)
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4-hydroxy-5,6-dihydro-2H-pyran-2-ones.3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1' and S2' of the HIV-1 protease enzyme
Ellsworth, E L, Domagala, J, Prasad, J V, Hagen, S, Ferguson, D, Holler, T, Hupe, D, Graham, N, Nouhan, C, Tummino, P J, Zeikus, G, Lunney, E A
Published in Bioorganic & medicinal chemistry letters (19.07.1999)
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Published in Bioorganic & medicinal chemistry letters (19.07.1999)
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Nonpeptidic HIV protease inhibitors: 3-(S-benzyl substituted)-4-hydroxy-6-(phenyl substituted)-2H-pyran-2-one with an inverse mode of binding
Vara Prasad, J.V.N., Pavlovsky, A., Para, Kimberly S., Ellsworth, Edmund L., Tummino, Peter J., Nouhan, Carolyn, Ferguson, Donna
Published in Bioorganic & medicinal chemistry letters (21.05.1996)
Published in Bioorganic & medicinal chemistry letters (21.05.1996)
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Journal Article
4-hydroxy-5,6-dihydro-2H-pyran-2-ones. 3. Bicyclic and heteroaromatic ring systems as 3-position scaffolds to bind to S1' and S2' of the HIV-1 protease enzyme
ELLSWORTH, E. L, DOMAGALA, J, ZEIKUS, G, LUNNEY, E. A, VARA PRASAD, J. V. N, HAGEN, S, FERGUSON, D, HOLLER, T, HUPE, D, GRAHAM, N, NOUHAN, C, TUMMINO, P. J
Published in Bioorganic & medicinal chemistry letters (1999)
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Published in Bioorganic & medicinal chemistry letters (1999)
Journal Article
4-Hydroxy-5,6-dihydropyrones. 2. Potent Non-Peptide Inhibitors of HIV Protease
Tait, Bradley D, Hagen, Susan, Domagala, John, Ellsworth, Edmund L, Gajda, Christopher, Hamilton, Harriet W, Vara Prasad, J. V. N, Ferguson, Donna, Graham, Neil, Hupe, Donald, Nouhan, Carolyn, Tummino, Peter J, Humblet, Christine, Lunney, Elizabeth A, Pavlovsky, Alexander, Rubin, John, Gracheck, Stephen J, Baldwin, Eric T, Bhat, T. N, Erickson, John W, Gulnik, Sergei V, Liu, Beishan
Published in Journal of medicinal chemistry (07.11.1997)
Published in Journal of medicinal chemistry (07.11.1997)
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Journal Article
Discovery and optimization of nonpeptide HIV-1 protease inhibitors
Tummino, Peter J., Vara Prasad, J.V.N., Ferguson, Donna, Nouhan, Carolyn, Graham, Neil, Domagala, John M., Ellsworth, Edmund, Gajda, Christopher, Hagen, Susan E., Lunney, Elizabeth A., Para, Kimberly S., Tait, Bradley D., Pavlovsky, Alexander, Erickson, John W., Gracheck, Stephen, McQuade, Thomas J., Hupe, Donald J.
Published in Bioorganic & medicinal chemistry (01.09.1996)
Published in Bioorganic & medicinal chemistry (01.09.1996)
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Nonpeptidic HIV protease inhibitors: 6-alkyl-5, 6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2- t-butyl, 5-methylphenyl thio) moiety: Antiviral activities and pharmacokinetic properties
Vara Prasad, J.V.N., Boyer, Fred E., Domagala, John M., Ellsworth, Edmund L., Gajda, Christopher, Hagen, Susan E., Markoski, Larry J., Tait, Bradley D., Lunney, Elizabeth A., Tummino, Peter J., Ferguson, Donna, Holler, Tod, Hupe, Donald, Nouhan, Carolyn, Gracheck, Stephen J., VanderRoest, Steven, Saunders, James, Iyer, Krishna, Sinz, Michael, Brodfuehrer, Joanne
Published in Bioorganic & medicinal chemistry letters (07.06.1999)
Published in Bioorganic & medicinal chemistry letters (07.06.1999)
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Journal Article
Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2- t-butyl-5-methyl-4-sulfamate)phenylthio moiety
Vara Prasad, J.V.N, Markoski, Larry J, Boyer, Fred E, Domagala, John M, Ellsworth, Edmund L, Gajda, Christopher, Hagen, Susan E, Tait, Bradley D, Lunney, Elizabeth A, Tummino, Peter J, Ferguson, Donna, Holler, Tod, Hupe, Donald, Nouhan, Carolyn, Gracheck, Stephen J, VanderRoest, Steven, Saunders, James, Iyer, K, Sinz, M
Published in Bioorganic & medicinal chemistry letters (02.08.1999)
Published in Bioorganic & medicinal chemistry letters (02.08.1999)
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