ASK1 contributes to fibrosis and dysfunction in models of kidney disease
Liles, John T, Corkey, Britton K, Notte, Gregory T, Budas, Grant R, Lansdon, Eric B, Hinojosa-Kirschenbaum, Ford, Badal, Shawn S, Lee, Michael, Schultz, Brian E, Wise, Sarah, Pendem, Swetha, Graupe, Michael, Castonguay, Laurie, Koch, Keith A, Wong, Melanie H, Papalia, Giuseppe A, French, Dorothy M, Sullivan, Theodore, Huntzicker, Erik G, Ma, Frank Y, Nikolic-Paterson, David J, Altuhaifi, Tareq, Yang, Haichun, Fogo, Agnes B, Breckenridge, David G
Published in The Journal of clinical investigation (01.10.2018)
Published in The Journal of clinical investigation (01.10.2018)
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Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis
Nygaard, Gyrid, Di Paolo, Julie A., Hammaker, Deepa, Boyle, David L., Budas, Grant, Notte, Gregory T., Mikaelian, Igor, Barry, Vivian, Firestein, Gary S.
Published in Biochemical pharmacology (01.05.2018)
Published in Biochemical pharmacology (01.05.2018)
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Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus
Gilmore, Sarah A, Tam, Danny, Cheung, Tara L, Snyder, Chelsea, Farand, Julie, Dick, Ryan, Matles, Mike, Feng, Joy Y, Ramirez, Ricardo, Li, Li, Yu, Helen, Xu, Yili, Barnes, Dwight, Czerwieniec, Gregg, Brendza, Katherine M, Appleby, Todd C, Birkus, Gabriel, Willkom, Madeleine, Kobayashi, Tetsuya, Paoli, Eric, Labelle, Marc, Boesen, Thomas, Tay, Chin H, Delaney, 4th, William E, Notte, Gregory T, Schmitz, Uli, Feierbach, Becket
Published in PloS one (07.12.2022)
Published in PloS one (07.12.2022)
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Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency
Farand, Julie, Mai, Nicholas, Chandrasekhar, Jayaraman, Newby, Zachary E., Van Veldhuizen, Josh, Loyer-Drew, Jennifer, Venkataramani, Chandrasekar, Guerrero, Juan, Kwok, Amy, Li, Ning, Zherebina, Yelena, Wilbert, Sibylle, Zablocki, Jeff, Phillips, Gary, Watkins, William J., Mourey, Robert, Notte, Gregory T.
Published in Bioorganic & medicinal chemistry letters (15.12.2016)
Published in Bioorganic & medicinal chemistry letters (15.12.2016)
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Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late I Nai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties
Zablocki, Jeff A, Elzein, Elfatih, Li, Xiaofen, Koltun, Dmitry O, Parkhill, Eric Q, Kobayashi, Tetsuya, Martinez, Ruben, Corkey, Britton, Jiang, Haibo, Perry, Thao, Kalla, Rao, Notte, Gregory T, Saunders, Oliver, Graupe, Michael, Lu, Yafan, Venkataramani, Chandru, Guerrero, Juan, Perry, Jason, Osier, Mark, Strickley, Robert, Liu, Gongxin, Wang, Wei-Qun, Hu, Lufei, Li, Xiao-Jun, El-Bizri, Nesrine, Hirakawa, Ryoko, Kahlig, Kris, Xie, Cheng, Li, Cindy Hong, Dhalla, Arvinder K, Rajamani, Sridharan, Mollova, Nevena, Soohoo, Daniel, Lepist, Eve-Irene, Murray, Bernard, Rhodes, Gerry, Belardinelli, Luiz, Desai, Manoj C
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
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Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine
Koltun, Dmitry O., Parkhill, Eric Q., Elzein, Elfatih, Kobayashi, Tetsuya, Notte, Gregory T., Kalla, Rao, Jiang, Robert H., Li, Xiaofen, Perry, Thao D., Avila, Belem, Wang, Wei-Qun, Smith-Maxwell, Catherine, Dhalla, Arvinder K., Rajamani, Sridharan, Stafford, Brian, Tang, Jennifer, Mollova, Nevena, Belardinelli, Luiz, Zablocki, Jeff A.
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
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Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation
Farand, Julie, Kropf, Jeffrey E, Blomgren, Peter, Xu, Jianjun, Schmitt, Aaron C, Newby, Zachary E, Wang, Ting, Murakami, Eisuke, Barauskas, Ona, Sudhamsu, Jawahar, Feng, Joy Y, Niedziela-Majka, Anita, Schultz, Brian E, Schwartz, Karen, Viatchenko-Karpinski, Serge, Kornyeyev, Dmytro, Kashishian, Adam, Fan, Peidong, Chen, Xiaowu, Lansdon, Eric B, Ports, Michael O, Currie, Kevin S, Watkins, William J, Notte, Gregory T
Published in ACS medicinal chemistry letters (12.03.2020)
Published in ACS medicinal chemistry letters (12.03.2020)
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Journal Article
Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus
Sarah A Gilmore, Danny Tam, Tara L Cheung, Chelsea Snyder, Julie Farand, Ryan Dick, Mike Matles, Joy Y Feng, Ricardo Ramirez, Li Li, Helen Yu, Yili Xu, Dwight Barnes, Gregg Czerwieniec, Katherine M Brendza, Todd C Appleby, Gabriel Birkus, Madeleine Willkom, Tetsuya Kobayashi, Eric Paoli, Marc Labelle, Thomas Boesen, Chin H Tay, William E Delaney, Gregory T Notte, Uli Schmitz, Becket Feierbach
Published in PloS one (07.12.2022)
Published in PloS one (07.12.2022)
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Journal Article
Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late I(Na)i) of the cardiac Na-V 1.5 channel with improved efficacy and potency relative to ranolazine
Koltun, Dmitry O., Parkhill, Eric Q., Elzein, Elfatih, Kobayashi, Tetsuya, Notte, Gregory T., Kalla, Rao, Jiang, Robert H., Li, Xiaofen, Perry, Thao D., Avila, Belem, Wang, Wei-Qun, Smith-Maxwell, Catherine, Dhalla, Arvinder K., Rajamani, Sridharan, Stafford, Brian, Tang, Jennifer, Mollova, Nevena, Belardinelli, Luiz, Zablocki, Jeff A.
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
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Journal Article
Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late I(Na)i), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties
Zablocki, Jeff A., Elzein, Elfatih, Li, Xiaofen, Koltun, Dmitry O., Parkhill, Eric Q., Kobayashi, Tetsuya, Martinez, Ruben, Corkey, Britton, Jiang, Haibo, Perry, Thao, Kalla, Rao, Notte, Gregory T., Saunders, Oliver, Graupe, Michael, Lu, Yafan, Venkataramani, Chandru, Guerrero, Juan, Perry, Jason, Osier, Mark, Strickley, Robert, Liu, Gongxin, Wang, Wei-Qun, Hu, Lufei, Li, Xiao-Jun, El-Bizri, Nesrine, Hirakawa, Ryoko, Kahlig, Kris, Xie, Cheng, Li, Cindy Hong, Dhalla, Arvinder K., Rajamani, Sridharan, Mollova, Nevena, Soohoo, Daniel, Lepist, Eve-Irene, Murray, Bernard, Rhodes, Gerry, Belardinelle, Luiz, Desai, Manoj C.
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
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Journal Article
ASK1 contributes to fibrosis and dysfunction in models of kidney disease
Liles, John T, Corkey, Britton K, Notte, Gregory T, Budas, Grant R, Lansdon, Eric B, Hinojosa-Kirschenbaum, d, Badal, Shawn S, Lee, Michael, Schultz, Brian E, Wise, Sarah, Pendem, Swetha, Graupe, Michael, Castonguay, Laurie, Koch, Keith A, Wong, Melanie H, Papalia, Giuseppe A, French, Dorothy M, Sullivan, Theodore, Huntzicker, Erik G, Ma, Frank Y, Nikolic-Paterson, David J, Altuhaifi, Tareq, Yang, Haichun, Fogo, Agnes B, Breckenridge, David G
Published in The Journal of clinical investigation (01.10.2018)
Published in The Journal of clinical investigation (01.10.2018)
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Journal Article
Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late I Na i) of the cardiac Na V 1.5 channel with improved efficacy and potency relative to ranolazine
Koltun, Dmitry O., Parkhill, Eric Q., Elzein, Elfatih, Kobayashi, Tetsuya, Notte, Gregory T., Kalla, Rao, Jiang, Robert H., Li, Xiaofen, Perry, Thao D., Avila, Belem, Wang, Wei-Qun, Smith-Maxwell, Catherine, Dhalla, Arvinder K., Rajamani, Sridharan, Stafford, Brian, Tang, Jennifer, Mollova, Nevena, Belardinelli, Luiz, Zablocki, Jeff A.
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
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Journal Article
PRMT5 INHIBITORS AND USES THEREOF
Mukherjee, Prasenjit K, Gupta, Pancham Lal, Yang, Zheng-Yu, Armstrong, Megan K, Debien, Laurent P, Chou, Chienhung, Roa, Daniel, Mitchell, Michael L, Nguyen, Shaina V, Chin, Elbert, Schrier, Adam J, Farr, Joshua D, Hung, Chao-I, Notte, Gregory T
Year of Publication 01.08.2024
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Year of Publication 01.08.2024
Patent
PRMT5 INHIBITORS AND USES THEREOF
HUNG, Chao-I, YANG, Zheng-Yu, MUKHERJEE, Prasenjit K, GUPTA, Pancham Lal, ARMSTRONG, Megan K, SCHRIER, Adam J, CHIN, Elbert, ROA, Daniel, CHOU, Chienhung, DEBIEN, Laurent P, NGUYEN, Shaina V, FARR, Joshua D, MITCHELL, Michael L, NOTTE, Gregory T
Year of Publication 27.06.2024
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Year of Publication 27.06.2024
Patent
Characterization of a KDM5 Small Molecule Inhibitor with Antiviral Activity against Hepatitis B Virus
Schmitz, Uli, Gilmore, Sarah A, Tam, Danny, Cheung, Tara L, Snyder, Chelsea, Farand, Julie, Ryan, Dick, Matles, Mike, Feng, Joy Y, Ramirez, Ricardo, Li, Li, Yu, Helen, Xu, Yili, Barnes, Dwight, Czerwieniec, Gregg, Brendza, Katherine M, Appleby, Todd C, Birkus, Gabriel, Willkom, Madeleine, Kobayashi, Tetsuya, Paoli, Eric, Labelle, Marc, Boesen, Thomas, Tay, Chin H, Delaney, William E, Notte, Gregory T, Becket Feierbach
Published in bioRxiv (30.06.2022)
Published in bioRxiv (30.06.2022)
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Paper